Epidermal growth factor receptor signaling mediates aldosterone-induced profibrotic responses in kidney - Sheng, Lili; Yang, Min; Ding, Wei; Zhang, Minmin; Niu, Jianying; Qiao, Zhongdong; Gu, Yong (Experimental cell research, 2016)
Keywords: 60 APPLIED LIFE SCIENCES; ALDOSTERONE; Aldosterone - adverse effects; ANIMAL TISSUES; Animals; Cell Line; Cell Movement - drug effects; CELL PROLIFERATION; Cell Proliferation - drug effects; COLLAGEN; COMPARATIVE EVALUATIONS; DISEASES; Epidermal growth factor receptor; ERK1/2; Erlotinib Hydrochloride - pharmacology; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; FIBROSIS; GROWTH FACTORS; HAZARDS; HYPERTROPHY; INHIBITION; Kidney - drug effects; Kidney - enzymology; Kidney - metabolism; Kidney - pathology; Kidney Glomerulus - drug effects; Kidney Glomerulus - pathology; KIDNEYS; Male; MAP Kinase Signaling System - drug effects; MATRICES; Mesangial Cells - drug effects; Mesangial Cells - pathology; Mice; MIGRATION; Models, Biological; OXIDATION; PHOSPHORYLATION; Phosphorylation - drug effects; PHOSPHOTRANSFERASES; PLANT GROWTH; PLANT TISSUES; POTENTIALS; Profibrotic response; RATS; Rats, Sprague-Dawley; Reactive oxidative stress; Reactive Oxygen Species - metabolism; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - metabolism; RECEPTORS; Receptors, Mineralocorticoid - metabolism; Signal Transduction - drug effects; SIGNALS; STRESSES; Transcriptional Activation - genetics; TYROSINE; ERK1/2; Profibrotic response; Reactive oxidative stress; Aldosterone; Epidermal growth factor receptor