Non-Coding RNA and Tumor Development in Neurofibromatosis Type 1: ANRIL Rs2151280 Is Associated with Optic Glioma Development and a Mild Phenotype in Neurofibromatosis Type 1 Patients

• Published in: Genes Vol. 10; no. 11; p. 892
• Main Authors: Tritto, Viviana, Ferrari, Luca, Esposito, Silvia, Zuccotti, Paola, Bianchessi, Donatella, Natacci, Federica, Saletti, Veronica, Eoli, Marica, Riva, Paola
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.11.2019; MDPI
• Subjects: anril variants; Astrocytoma; Astrocytoma - complications; Brain cancer; Brain tumors; Chromatin remodeling; DNA polymerase; Gene expression; Genes; Genes, Neurofibromatosis 1; Genetic disorders; Genotype; Genotypes; Glioma; Humans; Laboratories; Loss of Heterozygosity; Magnetic resonance imaging; MicroRNAs; MicroRNAs - genetics; mild nf1 phenotype; miRNA; Mutation; ncrna; Nerve Sheath Neoplasms - complications; Nervous system; Neurofibroma - complications; Neurofibroma, Plexiform - complications; Neurofibromatosis; Neurofibromatosis 1 - complications; Neurofibromatosis 1 - genetics; neurofibromatosis type 1; Neurological disorders; Non-coding RNA; optic glioma; Optic Nerve Glioma - complications; Optic Nerve Glioma - genetics; Optic Nerve Glioma - metabolism; Patients; Peripheral nerves; Phenotype; Phenotypes; Polymorphism; Post-transcription; Recklinghausen's disease; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Untranslated - genetics; Signal transduction; Signal Transduction - genetics; Software; tumor development; Tumors; United States > US; Germany; mild NF1 phenotype; neurofibromatosis type 1; tumor development; ANRIL variants; ncRNA; optic glioma

Non-coding RNAs (ncRNAs) are known to regulate gene expression at the transcriptional and post-transcriptional levels, chromatin remodeling, and signal transduction. The identification of different species of ncRNAs, microRNAs (miRNAs), circular RNAs (circRNAs), and long ncRNAs (lncRNAs)-and in some...