Effectiveness and Tolerability of Combination Pharmacotherapy With Stimulant and Non-Stimulant in Children With Attention Deficit Hyperactivity Disorder

• Published in: Journal of the Korean Academy of Child and Adolescent Psychiatry Vol. 35; no. 1; pp. 82 - 89
• Main Authors: Park, Hyung Nam, Kong, Na Yeong, Kim, Hee-Cheol, Kim, Yang Tae, Jung, Sung-Won, Lee, Hojun
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한소아청소년정신의학회 2024; Korean Academy of Child and Adolescent Psychiatry; 대한소아청소년 정신의학회
• Subjects: Amphetamines; Anxiety; Attention deficit hyperactivity disorder; Drug dosages; Drug therapy; Hyperactivity; Medical records; Mental disorders; Original; Patients; Psychiatrists; Tourette syndrome; Variance analysis; 정신과학; Atomoxetine; Child; Attention deficit hyperactivity disorder; Combination; Methylphenidate
• DOI: 10.5765/jkacap.230048
• ISSN: 1225-729X; 2233-9183

This study aimed to investigate the effectiveness and safety of combining psychostimulants and nonstimulants for patients under treatment for attention deficit hyperactivity disorder (ADHD). The study included 96 patients aged 6-12 years who were diagnosed with ADHD, among whom 34 received combination pharmacotherapy, 32 received methylphenidate monotherapy, and 30 received atomoxetine monotherapy. Statistical analysis was conducted to compare treatment and adverse effects among groups and to analyze changes before and after combination pharmacotherapy. The difference between combination pharmacotherapy and monotherapy was investigated. Logistic regression analysis was used to identify the predictors of combination pharmacotherapy. No significant differences were observed between the groups in terms of age or pretreatment scores. The most common adverse effect experienced by 32% of patients in the combination pharmacotherapy group was decreased appetite. Clinical global impression- severity score decreased significantly after combination pharmacotherapy. All three groups showed significant clinical global impression- severity score improvements over time, with no significant differences among them. The predictive factors for combination pharmacotherapy included the Child Behavior Checklist total score internalizing subscale. Combination pharmacotherapy with methylphenidate and atomoxetine is a relatively effective and safe option for patients with ADHD who do not respond to monotherapy.