Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is...

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Published inInternational journal of molecular sciences Vol. 22; no. 21; p. 11857
Main Authors Hung, Peir-Haur, Hsu, Yung-Chien, Chen, Tsung-Hsien, Lin, Chun-Liang
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.11.2021
MDPI
Subjects
Angiogenesis
Apoptosis
Cytokines
Dehydrogenases
Diabetes
Diabetic Nephropathies - complications
Diabetic Nephropathies - genetics
Diabetic Nephropathies - physiopathology
Diabetic nephropathy
Extracellular matrix
Fibroblasts
Gene Regulatory Networks
Glomerular Filtration Rate
Glucose
Humans
Hyperglycemia
Hypertension
Inflammation
Kidney diseases
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - genetics
Kidney Failure, Chronic - physiopathology
Kinases
Metabolism
Metabolites
Nitric oxide
Oxidative stress
Proteins
Review
Signal transduction
Tumor necrosis factor-TNF
diabetic kidney disease
albuminuria
fibrosis
glomerulosclerosis
inflammation
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Abstract Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.
AbstractList Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.
Author Chen, Tsung-Hsien
Hung, Peir-Haur
Hsu, Yung-Chien
Lin, Chun-Liang
AuthorAffiliation 2 Department of Applied Life Science and Health, Chia-Nan University of Pharmacy and Science, Tainan 717301, Taiwan
7 Center for Shockwave Medicine and Tissue Engineering, Chang Gung Memorial Hospital, Kaohsiung 833253, Taiwan
3 Department of Nephrology, Chang Gung Memorial Hospital, Chiayi 613016, Taiwan; libra@cgmh.org.tw
1 Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600566, Taiwan; dtmedg3@yahoo.com.tw (P.-H.H.); cych13794@gmail.com (T.-H.C.)
4 Kidney and Diabetic Complications Research Team (KDCRT), Chang Gung Memorial Hospital, Chiayi 613016, Taiwan
5 School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333423, Taiwan
6 Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan
AuthorAffiliation_xml – name: 2 Department of Applied Life Science and Health, Chia-Nan University of Pharmacy and Science, Tainan 717301, Taiwan
– name: 6 Kidney Research Center, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan
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– name: 5 School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333423, Taiwan
– name: 1 Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi 600566, Taiwan; dtmedg3@yahoo.com.tw (P.-H.H.); cych13794@gmail.com (T.-H.C.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34769288$$D View this record in MEDLINE/PubMed
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Issue 21
Keywords diabetic kidney disease
albuminuria
fibrosis
glomerulosclerosis
inflammation
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Snippet Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular...
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StartPage 11857
SubjectTerms Angiogenesis
Apoptosis
Cytokines
Dehydrogenases
Diabetes
Diabetic Nephropathies - complications
Diabetic Nephropathies - genetics
Diabetic Nephropathies - physiopathology
Diabetic nephropathy
Extracellular matrix
Fibroblasts
Gene Regulatory Networks
Glomerular Filtration Rate
Glucose
Humans
Hyperglycemia
Hypertension
Inflammation
Kidney diseases
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - genetics
Kidney Failure, Chronic - physiopathology
Kinases
Metabolism
Metabolites
Nitric oxide
Oxidative stress
Proteins
Review
Signal transduction
Tumor necrosis factor-TNF
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Title Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
URI https://www.ncbi.nlm.nih.gov/pubmed/34769288
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Volume 22
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