Promiscuity, a Driver of Plant Cytochrome P450 Evolution?

• Published in: Biomolecules (Basel, Switzerland) Vol. 13; no. 2; p. 394
• Main Author: Werck-Reichhart, Danièle
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.02.2023; MDPI
• Subjects: Biosynthesis; Cytochrome; Cytochrome P-450; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Enzymes; evolution; Gene Duplication; Genetic aspects; Genomes; herbicide resistance; Herbicides; Homeostasis; Hypotheses; Life Sciences; Metabolism; Metabolites; Natural history; plant defense; plant metabolism; Plants - metabolism; promiscuity; Review; Secondary Metabolism; Substrate preferences; Tobacco; France; plant defense; cytochrome P450; evolution; herbicide resistance; promiscuity; plant metabolism; cytochrome P450 plant metabolism promiscuity evolution plant defense herbicide resistance

Plant cytochrome P450 monooxygenases were long considered to be highly substrate-specific, regioselective and stereoselective enzymes, in this respect differing from their animal counterparts. The functional data that have recently accumulated clearly counter this initial dogma. Highly promiscuous P...