Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 5; p. 796
• Main Authors: Shou, Jia-Wen, Shaw, Pang-Chui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2022; MDPI
• Subjects: Alzheimer's disease; Apoptosis; Berberine; Berberine - pharmacology; Berberine - therapeutic use; Brain research; Dopamine; Enzymes; Herbal medicine; Humans; Hypotheses; Kinases; Medicinal plants; Memory; Metabolites; Nervous System Diseases - drug therapy; Neurological diseases; Neurological disorders; Oral administration; Parkinson's disease; Peptides; Proteins; Review; Therapeutic applications; Toxicity; Traumatic brain injury; neurological disorders; berberine

Neurological disorders are ranked as the leading cause of disability and the second leading cause of death worldwide, underscoring an urgent necessity to develop novel pharmacotherapies. Berberine (BBR) is a well-known phytochemical isolated from a number of medicinal herbs. BBR has attracted much i...