Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms

Neurological disorders are ranked as the leading cause of disability and the second leading cause of death worldwide, underscoring an urgent necessity to develop novel pharmacotherapies. Berberine (BBR) is a well-known phytochemical isolated from a number of medicinal herbs. BBR has attracted much i...

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Published inCells (Basel, Switzerland) Vol. 11; no. 5; p. 796
Main Authors Shou, Jia-Wen, Shaw, Pang-Chui
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.02.2022
MDPI
Subjects
Alzheimer's disease
Apoptosis
Berberine
Berberine - pharmacology
Berberine - therapeutic use
Brain research
Dopamine
Enzymes
Herbal medicine
Humans
Hypotheses
Kinases
Medicinal plants
Memory
Metabolites
Nervous System Diseases - drug therapy
Neurological diseases
Neurological disorders
Oral administration
Parkinson's disease
Peptides
Proteins
Review
Therapeutic applications
Toxicity
Traumatic brain injury
neurological disorders
berberine
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Abstract Neurological disorders are ranked as the leading cause of disability and the second leading cause of death worldwide, underscoring an urgent necessity to develop novel pharmacotherapies. Berberine (BBR) is a well-known phytochemical isolated from a number of medicinal herbs. BBR has attracted much interest for its broad range of pharmacological actions in treating and/or managing neurological disorders. The discoveries in basic and clinical studies of the effects of BBR on neurological disorders in the last decade have provided novel evidence to support the potential therapeutical efficacies of BBR in treating neurological diseases. In this review, we summarized the pharmacological properties and therapeutic applications of BBR against neurological disorders in the last decade. We also emphasized the major pathways modulated by BBR, which provides firm evidence for BBR as a promising drug candidate for neurological disorders.
AbstractList Neurological disorders are ranked as the leading cause of disability and the second leading cause of death worldwide, underscoring an urgent necessity to develop novel pharmacotherapies. Berberine (BBR) is a well-known phytochemical isolated from a number of medicinal herbs. BBR has attracted much interest for its broad range of pharmacological actions in treating and/or managing neurological disorders. The discoveries in basic and clinical studies of the effects of BBR on neurological disorders in the last decade have provided novel evidence to support the potential therapeutical efficacies of BBR in treating neurological diseases. In this review, we summarized the pharmacological properties and therapeutic applications of BBR against neurological disorders in the last decade. We also emphasized the major pathways modulated by BBR, which provides firm evidence for BBR as a promising drug candidate for neurological disorders.
Neurological disorders are ranked as the leading cause of disability and the second leading cause of death worldwide, underscoring an urgent necessity to develop novel pharmacotherapies. Berberine (BBR) is a well-known phytochemical isolated from a number of medicinal herbs. BBR has attracted much interest for its broad range of pharmacological actions in treating and/or managing neurological disorders. The discoveries in basic and clinical studies of the effects of BBR on neurological disorders in the last decade have provided novel evidence to support the potential therapeutical efficacies of BBR in treating neurological diseases. In this review, we summarized the pharmacological properties and therapeutic applications of BBR against neurological disorders in the last decade. We also emphasized the major pathways modulated by BBR, which provides firm evidence for BBR as a promising drug candidate for neurological disorders.Neurological disorders are ranked as the leading cause of disability and the second leading cause of death worldwide, underscoring an urgent necessity to develop novel pharmacotherapies. Berberine (BBR) is a well-known phytochemical isolated from a number of medicinal herbs. BBR has attracted much interest for its broad range of pharmacological actions in treating and/or managing neurological disorders. The discoveries in basic and clinical studies of the effects of BBR on neurological disorders in the last decade have provided novel evidence to support the potential therapeutical efficacies of BBR in treating neurological diseases. In this review, we summarized the pharmacological properties and therapeutic applications of BBR against neurological disorders in the last decade. We also emphasized the major pathways modulated by BBR, which provides firm evidence for BBR as a promising drug candidate for neurological disorders.
Author Shou, Jia-Wen
Shaw, Pang-Chui
AuthorAffiliation 3 State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants and Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong 852852, China
2 Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine, The Chinese University of Hong Kong, Hong Kong 852852, China
1 School of Life Sciences, The Chinese University of Hong Kong, Hong Kong 852852, China; shoujiawen@163.com
AuthorAffiliation_xml – name: 2 Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine, The Chinese University of Hong Kong, Hong Kong 852852, China
– name: 1 School of Life Sciences, The Chinese University of Hong Kong, Hong Kong 852852, China; shoujiawen@163.com
– name: 3 State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants and Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong 852852, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35269418$$D View this record in MEDLINE/PubMed
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berberine
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Snippet Neurological disorders are ranked as the leading cause of disability and the second leading cause of death worldwide, underscoring an urgent necessity to...
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SubjectTerms Alzheimer's disease
Apoptosis
Berberine
Berberine - pharmacology
Berberine - therapeutic use
Brain research
Dopamine
Enzymes
Herbal medicine
Humans
Hypotheses
Kinases
Medicinal plants
Memory
Metabolites
Nervous System Diseases - drug therapy
Neurological diseases
Neurological disorders
Oral administration
Parkinson's disease
Peptides
Proteins
Review
Therapeutic applications
Toxicity
Traumatic brain injury
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Title Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms
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Volume 11
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