Fecal Microbiota Transplantation: Is It Safe?
Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to be associated with delivery methods. Long...
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| Published in | Clinical endoscopy Vol. 54; no. 2; pp. 157 - 160 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Society of Gastrointestinal Endoscopy
01.03.2021
대한소화기내시경학회 |
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| Abstract | Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to be associated with delivery methods. Long-term side effects have not been established, and no signs of harm have been found to date. However, causality for several microbiome-associated diseases has to be established. Even though FMT is generally considered safe with strict donor screening, serious adverse events have been recently associated with the FMT product from the stool bank, where screening for multi-drug resistant organisms is not included in protocols. Here, we discuss the adverse events associated with FMT and safety issues. |
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| AbstractList | Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections.
FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to beassociated with delivery methods. Long-term side effects have not been established, and no signs of harm have been found to date.
However, causality for several microbiome-associated diseases has to be established. Even though FMT is generally considered safewith strict donor screening, serious adverse events have been recently associated with the FMT product from the stool bank, wherescreening for multi-drug resistant organisms is not included in protocols. Here, we discuss the adverse events associated with FMTand safety issues. KCI Citation Count: 0 Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to be associated with delivery methods. Long-term side effects have not been established, and no signs of harm have been found to date. However, causality for several microbiome-associated diseases has to be established. Even though FMT is generally considered safe with strict donor screening, serious adverse events have been recently associated with the FMT product from the stool bank, where screening for multi-drug resistant organisms is not included in protocols. Here, we discuss the adverse events associated with FMT and safety issues. Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to be associated with delivery methods. Long-term side effects have not been established, and no signs of harm have been found to date. However, causality for several microbiome-associated diseases has to be established. Even though FMT is generally considered safe with strict donor screening, serious adverse events have been recently associated with the FMT product from the stool bank, where screening for multi-drug resistant organisms is not included in protocols. Here, we discuss the adverse events associated with FMT and safety issues. |
| Author | Seo, Geom Seog Park, Seon-Young |
| Author_xml | – sequence: 1 givenname: Seon-Young surname: Park fullname: Park, Seon-Young organization: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea – sequence: 2 givenname: Geom Seog surname: Seo fullname: Seo, Geom Seog organization: Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33827154$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002699193$$DAccess content in National Research Foundation of Korea (NRF) |
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| Cites_doi | 10.1371/journal.pone.0161174 10.1038/ajg.2012.60 10.1371/journal.pone.0238910 10.1016/j.infpip.2020.100069 10.1111/tid.12967 10.1155/2018/1394379 10.1097/mcg.0000000000000511 10.1111/tid.12726 10.1093/cid/civ247 10.1056/nejmoa1910437 10.1136/gutjnl-2018-316818 10.1111/ajt.15058 10.1016/j.phrs.2020.104954 10.1016/j.chom.2018.01.003 10.1053/j.gastro.2015.04.001 10.1136/gutjnl-2020-321829 10.1016/s0140-6736(17)30182-4 10.1007/s10620-020-06147-z 10.1002/14651858.cd012774.pub2 10.1111/apt.14023 10.1016/j.dld.2020.09.004 10.1053/j.gastro.2020.09.038 |
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| Snippet | Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally... Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally... Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally... |
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| Title | Fecal Microbiota Transplantation: Is It Safe? |
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