The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 3; p. 572
• Main Authors: Liu, Jinmeng, Zhou, Fenghua, Guan, Yingjun, Meng, Fandi, Zhao, Zhenhan, Su, Qi, Bao, Weiwei, Wang, Xuemei, Zhao, Jiantao, Huo, Zijun, Zhang, Lingyun, Zhou, Shuanhu, Chen, Yanchun, Wang, Xin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.02.2022; MDPI
• Subjects: Alzheimer's disease; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - metabolism; biomarker; Biomarkers; Biomarkers - metabolism; Biosynthesis; Cytoplasm; Gene expression; Gene regulation; Gene therapy; Humans; Medical prognosis; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; miRNAs; Motor neurons; Motor Neurons - pathology; Musculoskeletal system; Mutation; neurodegeneration; Neurodegenerative diseases; Neurodegenerative Diseases - metabolism; noncoding RNA; Pathogenesis; Patients; Post-transcription; Review; therapy; neurodegeneration; noncoding RNA; miRNAs; biomarker; amyotrophic lateral sclerosis; therapy

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons. As there is no effective treatment for ALS, it is particularly important to screen key gene therapy targets. The identifications of microRNAs (miRNAs) have completely changed the traditiona...