Antiviral effects of Phyllanthus urinaria containing corilagin against human enterovirus 71 and Coxsackievirus A16 in vitro

• Published in: Archives of pharmacal research Vol. 38; no. 2; pp. 193 - 202
• Main Authors: Yeo, Sang-Gu, Song, Jae Hyoung, Hong, Eun-Hye, Lee, Bo-Ra, Kwon, Yong Soo, Chang, Sun-Young, Kim, Seung Hyun, Lee, Sang won, Park, Jae-Hak, Ko, Hyun-Jeong
• Format: Journal Article
• Language: English
• Published: Heidelberg Pharmaceutical Society of Korea 01.02.2015; 대한약학회
• Subjects: Animals; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; antiviral properties; Cell Survival - drug effects; central nervous system; Cercopithecus aethiops; children; Cytopathogenic Effect, Viral - drug effects; cytotoxicity; disease course; Dose-Response Relationship, Drug; drugs; Enterovirus A; Enterovirus A, Human - drug effects; Enterovirus A, Human - pathogenicity; Epithelial Cells - drug effects; Epithelial Cells - pathology; Epithelial Cells - virology; ethyl acetate; Glucosides - isolation & purification; Glucosides - pharmacology; hand, foot and mouth disease; Hydrolyzable Tannins - isolation & purification; Hydrolyzable Tannins - pharmacology; infants; lethal dose; Medicine; Pharmacology/Toxicology; Pharmacy; Phyllanthus - chemistry; Phyllanthus urinaria; Plant Components, Aerial - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Research Article; therapeutics; Vero Cells; 약학; Human enterovirus 71; Corilagin; Hand, foot, and mouth disease; Antiviral drug; Phyllanthus urinaria; Coxsackievirus A16

Human enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are major causative agents of hand, foot, and mouth disease (HFMD) especially in infants and children under 5 years of age. Despite recent outbreaks of HFMD, there are no approved therapeutics against EV71 and CA16 infection. Moreover, in a s...