Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 11; p. 3032
• Main Authors: Hwang, Joel Jihwan, Choi, Jinhyeok, Rim, Yeri Alice, Nam, Yoojun, Ju, Ji Hyeon
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.11.2021; MDPI
• Subjects: Age; Alzheimer's disease; Arthritis; Cartilage; Cell Differentiation; Clinical trials; disease modeling; Drug screening; Ethics; Etiology; Fibroblasts; Gene expression; Genomes; Heart rate; Humans; induced pluripotent stem cell; Induced Pluripotent Stem Cells - pathology; Joint diseases; Models, Biological; Obesity; Osteoarthritis; Osteoarthritis - pathology; Pathogenesis; Phenotypes; Pluripotency; Review; Risk assessment; Stem cells; Transcription factors; induced pluripotent stem cell; osteoarthritis; disease modeling

Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and plasticity. Hence, the clinical applicability of iPSCs was investigated in various fields of research. However, only a few iPSC studies pertaining to...