Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis

Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and plasticity. Hence, the clinical applicability of iPSCs was investigated in various fields of research. However, only a few iPSC studies pertaining to...

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Published inCells (Basel, Switzerland) Vol. 10; no. 11; p. 3032
Main Authors Hwang, Joel Jihwan, Choi, Jinhyeok, Rim, Yeri Alice, Nam, Yoojun, Ju, Ji Hyeon
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 05.11.2021
MDPI
Subjects
Age
Alzheimer's disease
Arthritis
Cartilage
Cell Differentiation
Clinical trials
disease modeling
Drug screening
Ethics
Etiology
Fibroblasts
Gene expression
Genomes
Heart rate
Humans
induced pluripotent stem cell
Induced Pluripotent Stem Cells - pathology
Joint diseases
Models, Biological
Obesity
Osteoarthritis
Osteoarthritis - pathology
Pathogenesis
Phenotypes
Pluripotency
Review
Risk assessment
Stem cells
Transcription factors
induced pluripotent stem cell
osteoarthritis
disease modeling
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Abstract Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and plasticity. Hence, the clinical applicability of iPSCs was investigated in various fields of research. However, only a few iPSC studies pertaining to osteoarthritis (OA) have been performed so far, despite the high prevalence rate of degenerative joint disease. In this review, we discuss some of the most recent applications of iPSCs in disease modeling and the construction of 3D models in various fields, specifically focusing on osteoarthritis and OA-related conditions. Notably, we comprehensively reviewed the successful results of iPSC-derived disease models in recapitulating OA phenotypes for both OA and early-onset OA to encompass their broad etiology. Moreover, the latest publications with protocols that have used iPSCs to construct 3D models in recapitulating various conditions, particularly the OA environment, were further discussed. With the overall optimistic results seen in both fields, iPSCs are expected to be more widely used for OA disease modeling and 3D model construction, which could further expand OA drug screening, risk assessment, and therapeutic capabilities.
AbstractList Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and plasticity. Hence, the clinical applicability of iPSCs was investigated in various fields of research. However, only a few iPSC studies pertaining to osteoarthritis (OA) have been performed so far, despite the high prevalence rate of degenerative joint disease. In this review, we discuss some of the most recent applications of iPSCs in disease modeling and the construction of 3D models in various fields, specifically focusing on osteoarthritis and OA-related conditions. Notably, we comprehensively reviewed the successful results of iPSC-derived disease models in recapitulating OA phenotypes for both OA and early-onset OA to encompass their broad etiology. Moreover, the latest publications with protocols that have used iPSCs to construct 3D models in recapitulating various conditions, particularly the OA environment, were further discussed. With the overall optimistic results seen in both fields, iPSCs are expected to be more widely used for OA disease modeling and 3D model construction, which could further expand OA drug screening, risk assessment, and therapeutic capabilities.
Author Choi, Jinhyeok
Nam, Yoojun
Hwang, Joel Jihwan
Rim, Yeri Alice
Ju, Ji Hyeon
AuthorAffiliation 2 YiPSCELL, Inc., 39 Banpo-daero, Seocho-gu, Seoul 06579, Korea; realshine@yipscell.com (J.C.); givingtreemax@yipscell.com (Y.N.)
4 Division of Rheumatology, Department of Internal Medicine, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul 06591, Korea
1 College of Public Health and Social Justice, Saint Louis University, St. Louis, MO 63103, USA; joel.hwang@slu.edu
3 Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; llyerill0114@gmail.com
AuthorAffiliation_xml – name: 1 College of Public Health and Social Justice, Saint Louis University, St. Louis, MO 63103, USA; joel.hwang@slu.edu
– name: 4 Division of Rheumatology, Department of Internal Medicine, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul 06591, Korea
– name: 3 Catholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; llyerill0114@gmail.com
– name: 2 YiPSCELL, Inc., 39 Banpo-daero, Seocho-gu, Seoul 06579, Korea; realshine@yipscell.com (J.C.); givingtreemax@yipscell.com (Y.N.)
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  surname: Rim
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  organization: Division of Rheumatology, Department of Internal Medicine, Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul 06591, Korea
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CitedBy_id crossref_primary_10_1016_j_mad_2023_111854
crossref_primary_10_3390_ijms241914408
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2021 by the authors. 2021
Copyright_xml – notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 11
Keywords induced pluripotent stem cell
osteoarthritis
disease modeling
Language English
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Snippet Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and...
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StartPage 3032
SubjectTerms Age
Alzheimer's disease
Arthritis
Cartilage
Cell Differentiation
Clinical trials
disease modeling
Drug screening
Ethics
Etiology
Fibroblasts
Gene expression
Genomes
Heart rate
Humans
induced pluripotent stem cell
Induced Pluripotent Stem Cells - pathology
Joint diseases
Models, Biological
Obesity
Osteoarthritis
Osteoarthritis - pathology
Pathogenesis
Phenotypes
Pluripotency
Review
Risk assessment
Stem cells
Transcription factors
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Title Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis
URI https://www.ncbi.nlm.nih.gov/pubmed/34831254
https://www.proquest.com/docview/2602023842
https://search.proquest.com/docview/2604016152
https://pubmed.ncbi.nlm.nih.gov/PMC8622662
https://doaj.org/article/5012ecf818cc449089bac8befa6eb0e5
Volume 10
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