BK virus–associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model

• Published in: Human pathology Vol. 44; no. 5; pp. 908 - 917
• Main Authors: Alexiev, Borislav A., MD, Randhawa, Parmjeet, MD, Vazquez Martul, Eduardo, MD, Zeng, Gang, MD, PhD, Luo, Chunqing, PhD, Ramos, Emilio, MD, Drachenberg, Cinthia B., MD, Papadimitriou, John C., MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2013; Elsevier Limited
• Subjects: Adenocarcinoma; Adenocarcinoma - etiology; Adenocarcinoma - virology; Adult; Antigens, Viral, Tumor - genetics; Automation; BK Virus - genetics; BK Virus - immunology; Bladder; Cancer; Carcinogenesis; Colleges & universities; Female; Health Insurance Portability & Accountability Act 1996-US; Humans; Immunosuppression - adverse effects; Kidney Transplantation - adverse effects; Male; Micropapillary; Microscopy; Middle Aged; Models, Biological; Mutation; Pathology; Polymerase chain reaction; Polyomavirus; Polyomavirus Infections - complications; Proteins; Review boards; Transplants & implants; Tumor Virus Infections - complications; Tumors; Urinary Bladder Neoplasms - etiology; Urinary Bladder Neoplasms - virology; Urogenital system; Urothelial; Virus Activation; Virus Replication; Adenocarcinoma; Micropapillary; Urothelial; Carcinogenesis; Polyomavirus

Summary Despite strong experimental evidence, BK polyomavirus involvement in human cancers has been controversial. We report 2 cases of kidney ± pancreas transplant recipients with evidence of BK polyomavirus reactivation, who developed aggressive urinary bladder urothelial carcinomas with adenocarc...