Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 37; no. 2; pp. 557 - 566
• Main Authors: Zuo, Lingjun, Gelernter, Joel, Zhang, Clarence K, Zhao, Hongyu, Lu, Lingeng, Kranzler, Henry R, Malison, Robert T, Li, Chiang-Shan R, Wang, Fei, Zhang, Xiang-Yang, Deng, Hong-Wen, Krystal, John H, Zhang, Fengyu, Luo, Xingguang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2012; Nature Publishing Group
• Subjects: 631/208/205/2138; 692/699/476/5; Adult; Alcoholism; Alcoholism - genetics; Behavioral Sciences; Biological Psychology; Black or African American - genetics; Case-Control Studies; Chromosomes, Human, Pair 1 - genetics; Collaboration; Datasets; Female; Gene Expression Profiling - methods; Gene Expression Profiling - statistics & numerical data; Genes; Genetic Predisposition to Disease - genetics; Genetics; Genome-Wide Association Study - methods; Genome-Wide Association Study - statistics & numerical data; Genomes; HapMap Project; Humans; Male; Medicine; Medicine & Public Health; Mental health; Metabolism; Neurosciences; Original; original-article; Pharmacotherapy; Polymorphism, Single Nucleotide; Proteins - genetics; Proteins - metabolism; Psychiatry; Public health; Quantitative Trait Loci - genetics; White People - genetics; United States > US; Connecticut; GWAS; eQTL; alcohol dependence; risk region

Previous studies using SAGE (the Study of Addiction: Genetics and Environment) and COGA (the Collaborative Study on the Genetics of Alcoholism) genome-wide association study (GWAS) data sets reported several risk loci for alcohol dependence (AD), which have not yet been well replicated independently...