CEP55 promotes cilia disassembly through stabilizing Aurora A kinase

• Published in: The Journal of cell biology Vol. 220; no. 2
• Main Authors: Zhang, Yu-Cheng, Bai, Yun-Feng, Yuan, Jin-Feng, Shen, Xiao-Lin, Xu, Yu-Ling, Jian, Xiao-Xiao, Li, Sen, Song, Zeng-Qing, Hu, Huai-Bin, Li, Pei-Yao, Tu, Hai-Qing, Han, Qiu-Ying, Wang, Na, Li, Ai-Ling, Zhang, Xue-Min, Wu, Min, Zhou, Tao, Li, Hui-Yan
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.02.2021
• Subjects: Abnormalities; Animals; Aurora Kinase A - metabolism; Cell Cycle Checkpoints; Cell Cycle Proteins - deficiency; Cell Cycle Proteins - metabolism; Cell surface; Cells, Cultured; Centrosome - metabolism; Centrosome - ultrastructure; Chaperonin Containing TCP-1 - metabolism; Cilia; Cilia - metabolism; Cilia - ultrastructure; Ciliary Motility Disorders - pathology; Defects; Development; Disease; Dismantling; Elongation; Encephalocele - pathology; Enzyme Stability; Gene Targeting; HEK293 Cells; Humans; In vivo methods and tests; Inactivation; Kidneys; Kinases; Mice; Mitosis; Mutation; Phenotype; Polycystic kidney; Polycystic Kidney Diseases - pathology; Protein Binding; Retinitis Pigmentosa - pathology; Smoothened Receptor - metabolism

Primary cilia protrude from the cell surface and have diverse roles during development and disease, which depends on the precise timing and control of cilia assembly and disassembly. Inactivation of assembly often causes cilia defects and underlies ciliopathy, while diseases caused by dysfunction in...