DNA methylation profiles in cancer diagnosis and therapeutics

• Published in: Clinical and experimental medicine Vol. 18; no. 1; pp. 1 - 14
• Main Authors: Pan, Yunbao, Liu, Guohong, Zhou, Fuling, Su, Bojin, Li, Yirong
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2018; Springer Nature B.V
• Subjects: Apoptosis; Biomarkers; Cancer; Cell cycle; Cell proliferation; Deoxyribonucleic acid; Diagnosis; DNA; DNA methylation; Epigenetics; Genetic transformation; Hematology; Internal Medicine; Medicine; Medicine & Public Health; Oncology; Precision medicine; Review Article; Tumorigenesis; DNMT inhibitor; DNA methylation; Epigenetics; Biomarker; Cancer

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with epigenetic modifications being increasingly identified as important targets for cancer research. DNA methylation catalyzed by DNA methyltransferases (DNMTs) is one of the essential epigenetic mechanisms that...