Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP 1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs

• Published in: Cytogenetic and genome research Vol. 88; no. 1-2; pp. 140 - 144
• Main Authors: LANTINGA-VAN LEEUWEN, I. S, KOOISTRA, H. S, MOL, J. A, RENIER, C, BREEN, M, VAN OOST, B. A
• Format: Journal Article
• Language: English
• Published: Freiburg Karger 01.01.2000; Basel S. Karger AG; Paris
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; chromosome 11; Cloning, Molecular; DNA Mutational Analysis; Dogs; Dwarfism - genetics; Exons - genetics; Female; Fundamental and applied biological sciences. Psychology; Genes. Genome; Genetic Linkage - genetics; Homeodomain Proteins - genetics; Hybrid Cells; In Situ Hybridization, Fluorescence; Introns - genetics; Male; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Pedigree; Physical Chromosome Mapping; Pit-1 gene; Pituitary Hormones - deficiency; Polymerase Chain Reaction; Prop-1 protein; PROP1 gene; Sequence Alignment; Transcription Factors - genetics; Genetic mapping; Fissipedia; Carnivora; Genome organization; Genetic marker; Nucleotide sequence; Deficiency; Homology; Dwarfism; Vertebrata; Pituitary hormone; Mammalia; Gene; Fluorescence in situ hybridization; Chromosome 11; Dog; Physical map

Abnormalities in the genes encoding Pit-1 and Prop-1 have been reported to cause combined pituitary hormone deficiency (CPHD) in mice and humans. In dogs, a similar phenotype has been described in the German shepherd breed. We have previously reported that the Pit-1 gene (POU1F1) is not mutated in a...