Biological Aging and the Human Gut Microbiota

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 72; no. 11; p. 1474
• Main Authors: Maffei, Vincent J, Kim, Sangkyu, Blanchard, 4th, Eugene, Luo, Meng, Jazwinski, S Michal, Taylor, Christopher M, Welsh, David A
• Format: Journal Article
• Language: English
• Published: United States 01.11.2017
• Subjects: Adult; Aged; Aging - physiology; Algorithms; Computational Biology - methods; Female; Gastrointestinal Microbiome - physiology; High-Throughput Nucleotide Sequencing; Humans; Male; Metagenomics - methods; Middle Aged; Phylogeny; RNA, Ribosomal, 16S - genetics; Frailty; Coabundance; Dysbiosis; Diversity

The human gastrointestinal microbiota plays a key homeostatic role in normal functioning of physiologic processes commonly undermined by aging. We used a previously validated 34-item frailty index (FI34) to identify changes in gut microbiota community structure associated with biological age of comm...