Expression of Chicken Toll-Like Receptors and Signal Adaptors in Spleen and Cecum of Young Chickens Infected with Eimeria tenella
Toll-like receptors （TLRs） are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of microbes. Understanding the changes in chicken Toll-like receptors （ChTLRs） and signal adaptors expression that occur with Eimeria tenella i...
Saved in:
| Published in | Journal of Integrative Agriculture Vol. 13; no. 4; pp. 904 - 910 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Science Press
01.04.2014
Department of Veterinary Medicine, Rongchang Campus of Southwest University, Chongqing 402460, P.R.China%College of Animal Science and Technology, Southwest University, Chongqing 400715, P.R.China KeAi Communications Co., Ltd |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Toll-like receptors （TLRs） are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of microbes. Understanding the changes in chicken Toll-like receptors （ChTLRs） and signal adaptors expression that occur with Eimeria tenella infection will help to elucidate the molecular basis of immune control of coccidiosis caused by Eimeria. The present study detected the dynamic changes in the expression of ChTLRs and associated signal adaptors in the spleen and cecum ofE. tenella-infected chickens during the early stage of infection. The results showed that the expression peak for ChTLRs, MyD88 and TRIF occurred at 12 h post-infection （hpi）, ChTLR3, ChTLRI 5 and MyD88 mRNA expression in the spleen ofE. tenella infected chickens were significantly higher （P〈0.05） than that of negative control chickens, and there were similar tendencies of these molecules expression in the cecum and spleen of E. tenella-infected chickens. The expression of MyD88 was upregnlated at four time points in the cecum of E. tenella-infected chickens. The results of this study indicate that ChTLR3, ChTLR15 and MyD88 play a role in young chickens infected with E. tenella. |
|---|---|
| AbstractList | Toll-like receptors （TLRs） are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of microbes. Understanding the changes in chicken Toll-like receptors （ChTLRs） and signal adaptors expression that occur with Eimeria tenella infection will help to elucidate the molecular basis of immune control of coccidiosis caused by Eimeria. The present study detected the dynamic changes in the expression of ChTLRs and associated signal adaptors in the spleen and cecum ofE. tenella-infected chickens during the early stage of infection. The results showed that the expression peak for ChTLRs, MyD88 and TRIF occurred at 12 h post-infection （hpi）, ChTLR3, ChTLRI 5 and MyD88 mRNA expression in the spleen ofE. tenella infected chickens were significantly higher （P〈0.05） than that of negative control chickens, and there were similar tendencies of these molecules expression in the cecum and spleen of E. tenella-infected chickens. The expression of MyD88 was upregnlated at four time points in the cecum of E. tenella-infected chickens. The results of this study indicate that ChTLR3, ChTLR15 and MyD88 play a role in young chickens infected with E. tenella. Toll-like receptors (TLRs) are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of microbes. Understanding the changes in chicken Toll-like receptors (ChTLRs) and signal adaptors expression that occur with Eimeria tenella infection will help to elucidate the molecular basis of immune control of coccidiosis caused by Eimeria. The present study detected the dynamic changes in the expression of ChTLRs and associated signal adaptors in the spleen and cecum of E. tenella-infected chickens during the early stage of infection. The results showed that the expression peak for ChTLRs, MyD88 and TRIF occurred at 12 h post-infection (hpi), ChTLR3, ChTLR15 and MyD88 mRNA expression in the spleen of E. tenella infected chickens were signiifcantly higher (P<0.05) than that of negative control chickens, and there were similar tendencies of these molecules expression in the cecum and spleen of E. tenella-infected chickens. The expression of MyD88 was upregulated at four time points in the cecum of E. tenella-infected chickens. The results of this study indicate that ChTLR3, ChTLR15 and MyD88 play a role in young chickens infected with E. tenella. Toll-like receptors (TLRs) are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of microbes. Understanding the changes in chicken Toll-like receptors (ChTLRs) and signal adaptors expression that occur with Eimeria tenella infection will help to elucidate the molecular basis of immune control of coccidiosis caused by Eimeria. The present study detected the dynamic changes in the expression of ChTLRs and associated signal adaptors in the spleen and cecum of E. tenella-infected chickens during the early stage of infection. The results showed that the expression peak for ChTLRs, MyD88 and TRIF occurred at 12 h post-infection (hpi), ChTLR3, ChTLR15 and MyD88 mRNA expression in the spleen of E. tenella infected chickens were significantly higher (P<0.05) than that of negative control chickens, and there were similar tendencies of these molecules expression in the cecum and spleen of E. tenella-infected chickens. The expression of MyD88 was upregulated at four time points in the cecum of E. tenella-infected chickens. The results of this study indicate that ChTLR3, ChTLR15 and MyD88 play a role in young chickens infected with E. tenella. |
| Author | ZHOU Zuo-yong HU Shi-jun WANG Zhi-ying GUO Zhi-li QIN Bo NIE Kui |
| AuthorAffiliation | Department of Veterinary Medicine, Rongchang Campus of Southwest University, Chongqing 402460, P.R.China College of Animal Science and Technology, Southwest University, Chongqing 400715, P.R. China |
| AuthorAffiliation_xml | – name: Department of Veterinary Medicine, Rongchang Campus of Southwest University, Chongqing 402460, P.R.China%College of Animal Science and Technology, Southwest University, Chongqing 400715, P.R.China |
| Author_xml | – sequence: 1 givenname: Zuo-yong surname: ZHOU fullname: ZHOU, Zuo-yong – sequence: 2 givenname: Shi-jun surname: HU fullname: HU, Shi-jun – sequence: 3 givenname: Zhi-ying surname: WANG fullname: WANG, Zhi-ying – sequence: 4 givenname: Zhi-li surname: GUO fullname: GUO, Zhi-li – sequence: 5 givenname: Bo surname: QIN fullname: QIN, Bo – sequence: 6 givenname: Kui surname: NIE fullname: NIE, Kui |
| BookMark | eNqFkT9v2zAQxYUiBZqm-QgB2C0ZlPKfKAmdAsNtDBgtUKdDJ-JEnWTaMumQMpJ06zevZMVLl3IhcffeD7x775Mz5x0myRWjt4wy9WnFaZmlgrHymokbRUUhU_UmOeci46mQPDsb3ifJu-Qyxg2llGUZpao4T_7Mn_cBY7TeEd-Q2dqaLTry4LsuXdotkh9ocN_7EAm4mqxs66AjdzVMNevIat_h4Bi7MzSH3Yj55Q-uPcEiWbgGTY81ebL9msztDoMF0qPDroMPydsGuoiXr_dF8vPL_GF2ny6_f13M7papkQXr00pVjGV5DUxyU-fDKQzWhmcCaIN50zQFrVRZlZniOZMFypxXknFmeFMOaxEXyWLi1h42eh_sDsKL9mD1seBDqyH01nSoC8UZlFgjUiUBSqAVR8hqSSugBWMD62ZiPYFrwLV64w9hWEzUv1v3sn3WyCmTVFKuBu31pN0H_3jA2OudjWac3KE_RM3HOCQtxSj9PElN8DEGbLSxPfRDNn0A22lG9Zi5Pmaux0A1E_qYuR7d2T_u05D_811Nvga8hjbYqGffhv8rQRnP86H_8ZW79q59tMO4J7AsM5ZTlYu_THbEmQ |
| CitedBy_id | crossref_primary_10_1038_s41598_021_85872_5 crossref_primary_10_1186_s40104_019_0353_6 crossref_primary_10_1038_s41598_021_97880_6 crossref_primary_10_1017_S0007114514001846 crossref_primary_10_1017_S1751731119000600 crossref_primary_10_1051_parasite_2019009 crossref_primary_10_3390_vaccines9090960 |
| Cites_doi | 10.1016/j.vetmic.2009.12.008 10.1128/IAI.74.3.1692-1698.2006 10.1016/j.vetmic.2009.01.024 10.1016/j.molimm.2007.09.013 10.1016/j.dci.2007.05.003 10.1016/j.dci.2010.11.012 10.1016/j.smim.2006.12.004 10.1128/IAI.72.4.1920-1928.2004 10.1016/j.vetimm.2009.06.007 10.1016/S0165-2427(96)05689-9 10.1637/7306-11150R 10.2307/1590540 10.1016/j.dci.2007.09.003 10.1007/s00441-010-1026-0 10.1080/03079450220148988 10.1016/j.bbrc.2009.08.062 10.1016/j.vetimm.2006.08.006 10.1016/j.exppara.2010.12.002 10.1016/j.exppara.2012.01.013 10.1128/IAI.71.11.6653-6657.2003 10.1016/S1471-4906(03)00115-7 10.1016/j.vaccine.2011.03.022 10.1111/j.1365-2796.2007.01821.x 10.1038/35100529 10.1186/1471-2164-9-62 10.3382/ps.2010-01246 10.1016/j.vetimm.2008.02.010 10.1038/nri1978 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W95 ~WA FBQ AAYXX CITATION 7S9 L.6 2B. 4A8 92I 93N PSX TCJ DOA |
| DOI | 10.1016/S2095-3119(13)60384-6 |
| DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 中文科技期刊数据库-7.0平台 中文科技期刊数据库-农业科学 中文科技期刊数据库- 镜像站点 AGRIS CrossRef AGRICOLA AGRICOLA - Academic Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) DOAJ Open Access Full Text |
| DatabaseTitle | CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture |
| DocumentTitleAlternate | Expression of Chicken Toll-Like Receptors and Signal Adaptors in Spleen and Cecum of Young Chickens Infected with Eimeria tenella |
| EISSN | 2352-3425 |
| EndPage | 910 |
| ExternalDocumentID | oai_doaj_org_article_8621a9edee064aa9a0b2ea5d40ba0811 zgnykx_e201404026 10_1016_S2095_3119_13_60384_6 CN2016301277 49517067 |
| GroupedDBID | --M -04 -0D -SD -S~ .~1 0R~ 1B1 1~. 1~5 2B. 2B~ 2RA 4.4 457 4G. 5VR 7-5 8P~ 92G 92I 92L 92M 93N 93Q 9D9 9DD AABNK AABVA AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AATLK AAXUO ABGRD ABMAC ABXDB ABYKQ ACDAQ ACGFS ACRLP ADEZE ADMUD ADQTV AEBSH AEKER AENEX AEQOU AFKWA AFTJW AFUIB AFXIZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CAJED CAJUS CBWCG CCEZO CHDYS CQIGP EBS EFJIC EFLBG EJD FA0 FDB FIRID FNPLU FYGXN GBLVA GROUPED_DOAJ HZ~ JUIAU KOM M41 MO0 NCXOZ O-L O9- OAUVE OK1 P-8 P-9 PC. Q-- Q-3 Q38 R-D RIG ROL RT4 SDF SDG SES SSA SSZ T5K T8T TCJ TGD U1F U1G U5D U5N W95 ~G- ~WA ABPIF FBQ AAHBH AATTM AAXKI AAYWO AAYXX ABJNI ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN AEIPS AEUPX AFJKZ AFPUW AGCQF AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH 7S9 L.6 4A8 PSX EFKBS |
| ID | FETCH-LOGICAL-c481t-b6b1157da142cd77778cedc253a0fe7fff80b69b95627148e472b4121c2f96033 |
| IEDL.DBID | DOA |
| ISSN | 2095-3119 |
| IngestDate | Wed Aug 27 01:05:01 EDT 2025 Thu May 29 03:54:11 EDT 2025 Fri Jul 11 09:54:02 EDT 2025 Tue Jul 01 01:08:35 EDT 2025 Thu Apr 24 23:11:43 EDT 2025 Tue Nov 07 23:17:43 EST 2023 Wed Feb 14 10:37:19 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Eimeria tenella signal adaptors Toll-like receptors spleen and cecum chicken |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 http://creativecommons.org/licenses/by-nc-nd/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c481t-b6b1157da142cd77778cedc253a0fe7fff80b69b95627148e472b4121c2f96033 |
| Notes | 10-1039/S Eimeria tenella, signal adaptors, Toll-like receptors, spleen and cecum, chicken Toll-like receptors （TLRs） are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of microbes. Understanding the changes in chicken Toll-like receptors （ChTLRs） and signal adaptors expression that occur with Eimeria tenella infection will help to elucidate the molecular basis of immune control of coccidiosis caused by Eimeria. The present study detected the dynamic changes in the expression of ChTLRs and associated signal adaptors in the spleen and cecum ofE. tenella-infected chickens during the early stage of infection. The results showed that the expression peak for ChTLRs, MyD88 and TRIF occurred at 12 h post-infection （hpi）, ChTLR3, ChTLRI 5 and MyD88 mRNA expression in the spleen ofE. tenella infected chickens were significantly higher （P〈0.05） than that of negative control chickens, and there were similar tendencies of these molecules expression in the cecum and spleen of E. tenella-infected chickens. The expression of MyD88 was upregnlated at four time points in the cecum of E. tenella-infected chickens. The results of this study indicate that ChTLR3, ChTLR15 and MyD88 play a role in young chickens infected with E. tenella. http://dx.doi.org/10.1016/S2095-3119(13)60384-6 http://www.chinaagrisci.com/Jwk_zgnykxen/fileup/PDF/2014, 13(3)-904.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/8621a9edee064aa9a0b2ea5d40ba0811 |
| PQID | 2000140936 |
| PQPubID | 24069 |
| PageCount | 7 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8621a9edee064aa9a0b2ea5d40ba0811 wanfang_journals_zgnykx_e201404026 proquest_miscellaneous_2000140936 crossref_citationtrail_10_1016_S2095_3119_13_60384_6 crossref_primary_10_1016_S2095_3119_13_60384_6 fao_agris_CN2016301277 chongqing_primary_49517067 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20140401 |
| PublicationDateYYYYMMDD | 2014-04-01 |
| PublicationDate_xml | – month: 04 year: 2014 text: 20140401 day: 01 |
| PublicationDecade | 2010 |
| PublicationTitle | Journal of Integrative Agriculture |
| PublicationTitleAlternate | Agricultural Sciences in China |
| PublicationTitle_FL | Journal of Integrative Agriculture |
| PublicationYear | 2014 |
| Publisher | Science Press Department of Veterinary Medicine, Rongchang Campus of Southwest University, Chongqing 402460, P.R.China%College of Animal Science and Technology, Southwest University, Chongqing 400715, P.R.China KeAi Communications Co., Ltd |
| Publisher_xml | – name: Science Press – name: Department of Veterinary Medicine, Rongchang Campus of Southwest University, Chongqing 402460, P.R.China%College of Animal Science and Technology, Southwest University, Chongqing 400715, P.R.China – name: KeAi Communications Co., Ltd |
| References | Kumar (10.1016/S2095-3119(13)60384-6_bib17) 2009; 388 Jeurissen (10.1016/S2095-3119(13)60384-6_bib13) 1996; 54 Abasht (10.1016/S2095-3119(13)60384-6_bib1) 2008; 123 Li (10.1016/S2095-3119(13)60384-6_bib18) 2010; 143 Temperley (10.1016/S2095-3119(13)60384-6_bib25) 2008; 9 Williams (10.1016/S2095-3119(13)60384-6_bib27) 2002; 31 Gazzinelli (10.1016/S2095-3119(13)60384-6_bib9) 2006; 6 Dalloul (10.1016/S2095-3119(13)60384-6_bib7) 2005; 49 Higuchi (10.1016/S2095-3119(13)60384-6_bib11) 2008; 32 Brownlie (10.1016/S2095-3119(13)60384-6_bib5) 2011; 343 Augustine (10.1016/S2095-3119(13)60384-6_bib3) 1986; 30 Totemeyer (10.1016/S2095-3119(13)60384-6_bib26) 2003; 71 Ciraci (10.1016/S2095-3119(13)60384-6_bib6) 2011; 35 Higgs (10.1016/S2095-3119(13)60384-6_bib10) 2006; 74 Del (10.1016/S2095-3119(13)60384-6_bib8) 2011; 29 Sumners (10.1016/S2095-3119(13)60384-6_bib23) 2011; 127 Keestra (10.1016/S2095-3119(13)60384-6_bib15) 2008; 45 Medzhitov (10.1016/S2095-3119(13)60384-6_bib20) 2001; 1 Swaggerty (10.1016/S2095-3119(13)60384-6_bib24) 2011; 90 MacKinnon (10.1016/S2095-3119(13)60384-6_bib19) 2009; 137 Albiger (10.1016/S2095-3119(13)60384-6_bib2) 2007; 261 O'Neill (10.1016/S2095-3119(13)60384-6_bib21) 2003; 24 Brisbin (10.1016/S2095-3119(13)60384-6_bib4) 2008; 32 Hong (10.1016/S2095-3119(13)60384-6_bib12) 2006; 114 Shaughnessy (10.1016/S2095-3119(13)60384-6_bib22) 2009; 132 Kawai (10.1016/S2095-3119(13)60384-6_bib14) 2007; 19 Zhang (10.1016/S2095-3119(13)60384-6_bib28) 2012; 130 Kropf (10.1016/S2095-3119(13)60384-6_bib16) 2004; 72 |
| References_xml | – volume: 143 start-page: 346 year: 2010 ident: 10.1016/S2095-3119(13)60384-6_bib18 article-title: Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum publication-title: Veterinary Microbiology doi: 10.1016/j.vetmic.2009.12.008 – volume: 74 start-page: 1692 year: 2006 ident: 10.1016/S2095-3119(13)60384-6_bib10 article-title: Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar typhimurium infection publication-title: Infection and Immunity doi: 10.1128/IAI.74.3.1692-1698.2006 – volume: 137 start-page: 313 year: 2009 ident: 10.1016/S2095-3119(13)60384-6_bib19 article-title: Expression profile of toll-like receptors within the gastrointestinal tract of 2-day-old Salmonella enteriditis-infected broiler chickens publication-title: Veterinary Microbiology doi: 10.1016/j.vetmic.2009.01.024 – volume: 45 start-page: 1298 year: 2008 ident: 10.1016/S2095-3119(13)60384-6_bib15 article-title: Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin publication-title: Molecular Immunology doi: 10.1016/j.molimm.2007.09.013 – volume: 32 start-page: 147 year: 2008 ident: 10.1016/S2095-3119(13)60384-6_bib11 article-title: Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily publication-title: Developmental and Comparative Immunology doi: 10.1016/j.dci.2007.05.003 – volume: 35 start-page: 392 year: 2011 ident: 10.1016/S2095-3119(13)60384-6_bib6 article-title: Avian-specific TLRs and downstream effector responses to CpG-induction in chicken macrophages publication-title: Developmental and Comparative Immunology doi: 10.1016/j.dci.2010.11.012 – volume: 19 start-page: 24 year: 2007 ident: 10.1016/S2095-3119(13)60384-6_bib14 article-title: TLR signaling publication-title: Seminars in Immunology doi: 10.1016/j.smim.2006.12.004 – volume: 72 start-page: 1920 year: 2004 ident: 10.1016/S2095-3119(13)60384-6_bib16 article-title: Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major publication-title: Infection and Immunity doi: 10.1128/IAI.72.4.1920-1928.2004 – volume: 132 start-page: 191 year: 2009 ident: 10.1016/S2095-3119(13)60384-6_bib22 article-title: Innate immune gene expression differentiates the early avian intestinal response between Salmonella and Campylobacter publication-title: Veterinary Immunology and Immunopathology doi: 10.1016/j.vetimm.2009.06.007 – volume: 54 start-page: 231 year: 1996 ident: 10.1016/S2095-3119(13)60384-6_bib13 article-title: Eimeria tenella infections in chickens: aspects of host-parasite: interaction publication-title: Veterinary Immunology and Immunopathology doi: 10.1016/S0165-2427(96)05689-9 – volume: 49 start-page: 1 year: 2005 ident: 10.1016/S2095-3119(13)60384-6_bib7 article-title: Recent advances in immunomodulation and vaccination strategies against coccidiosis publication-title: Avian Disease doi: 10.1637/7306-11150R – volume: 30 start-page: 347 year: 1986 ident: 10.1016/S2095-3119(13)60384-6_bib3 article-title: A study of the dynamics of the invasion of immunized birds by Eimeria sporozoites publication-title: Avian Disease doi: 10.2307/1590540 – volume: 32 start-page: 563 year: 2008 ident: 10.1016/S2095-3119(13)60384-6_bib4 article-title: Gene expression profiling of chicken lymphoid cells after treatment with Lactobacillus acidophilus cellular components publication-title: Developmental and Comparative Immunology doi: 10.1016/j.dci.2007.09.003 – volume: 343 start-page: 121 year: 2011 ident: 10.1016/S2095-3119(13)60384-6_bib5 article-title: Avian toll-like receptors publication-title: Cell and Tissue Research doi: 10.1007/s00441-010-1026-0 – volume: 31 start-page: 317 year: 2002 ident: 10.1016/S2095-3119(13)60384-6_bib27 article-title: Anticoccidial vaccines for broiler chickens: pathways to success publication-title: Avian Pathology doi: 10.1080/03079450220148988 – volume: 388 start-page: 621 year: 2009 ident: 10.1016/S2095-3119(13)60384-6_bib17 article-title: Toll-like receptors and innate immunity publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2009.08.062 – volume: 114 start-page: 259 year: 2006 ident: 10.1016/S2095-3119(13)60384-6_bib12 article-title: Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens publication-title: Veterinary Immunology and Immunopathology doi: 10.1016/j.vetimm.2006.08.006 – volume: 127 start-page: 714 year: 2011 ident: 10.1016/S2095-3119(13)60384-6_bib23 article-title: Expression of Toll-like receptors and antimicrobial peptides during Eimeria praecox infection in chickens publication-title: Experimental Parasitology doi: 10.1016/j.exppara.2010.12.002 – volume: 130 start-page: 442 year: 2012 ident: 10.1016/S2095-3119(13)60384-6_bib28 article-title: Eimeria tenella: expression profiling of toll-like receptors and associated cytokines in the cecum of infected day-old and three-week old SPF chickens publication-title: Experimental Parasitology doi: 10.1016/j.exppara.2012.01.013 – volume: 71 start-page: 6653 year: 2003 ident: 10.1016/S2095-3119(13)60384-6_bib26 article-title: Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar typhimurium infection publication-title: Infection and Immunity doi: 10.1128/IAI.71.11.6653-6657.2003 – volume: 24 start-page: 286 year: 2003 ident: 10.1016/S2095-3119(13)60384-6_bib21 article-title: The Toll-IL-1 receptor adaptor family grows to five members publication-title: Trends in Immunology doi: 10.1016/S1471-4906(03)00115-7 – volume: 29 start-page: 3818 year: 2011 ident: 10.1016/S2095-3119(13)60384-6_bib8 article-title: Induction of protective immunity against Eimeria tenella infection using antigen-loaded dendritic cells (DC) and DC-derived exosomes publication-title: Vaccine doi: 10.1016/j.vaccine.2011.03.022 – volume: 261 start-page: 511 year: 2007 ident: 10.1016/S2095-3119(13)60384-6_bib2 article-title: Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors publication-title: Journal of Internal Medicine doi: 10.1111/j.1365-2796.2007.01821.x – volume: 1 start-page: 135 year: 2001 ident: 10.1016/S2095-3119(13)60384-6_bib20 article-title: Toll-like receptors and innate immunity publication-title: Nature Reviews Immunology doi: 10.1038/35100529 – volume: 9 start-page: 62 year: 2008 ident: 10.1016/S2095-3119(13)60384-6_bib25 article-title: Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss publication-title: BMC Genomics doi: 10.1186/1471-2164-9-62 – volume: 90 start-page: 1014 year: 2011 ident: 10.1016/S2095-3119(13)60384-6_bib24 article-title: Broiler breeders with an efficient innate immune response are more resistant to Eimeria tenella publication-title: Poultry Science doi: 10.3382/ps.2010-01246 – volume: 123 start-page: 314 year: 2008 ident: 10.1016/S2095-3119(13)60384-6_bib1 article-title: Toll-like receptor gene expression in cecum and spleen of advanced intercross line chicks infected with Salmonella enterica serovar Enteritidis publication-title: Veterinary Immunology and Immunopathology doi: 10.1016/j.vetimm.2008.02.010 – volume: 6 start-page: 895 year: 2006 ident: 10.1016/S2095-3119(13)60384-6_bib9 article-title: Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism publication-title: Nature Reviews Immunology doi: 10.1038/nri1978 |
| SSID | ssj0001550068 |
| Score | 1.9878817 |
| Snippet | Toll-like receptors （TLRs） are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of... Toll-like receptors (TLRs) are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of... |
| SourceID | doaj wanfang proquest crossref fao chongqing |
| SourceType | Open Website Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 904 |
| SubjectTerms | cecum chicken chickens coccidiosis Eimeria tenella Eimeria tenella signal adaptors Toll-like receptors spleen and cecum chicken gene expression innate immunity messenger RNA microorganisms pathogens signal adaptors spleen spleen and cecum Toll-like receptors Toll样受体 信号 柔嫩艾美耳球虫 球虫感染 盲肠 脾脏 适配器 雏鸡 |
| Title | Expression of Chicken Toll-Like Receptors and Signal Adaptors in Spleen and Cecum of Young Chickens Infected with Eimeria tenella |
| URI | http://lib.cqvip.com/qk/86610A/201404/49517067.html https://www.proquest.com/docview/2000140936 https://d.wanfangdata.com.cn/periodical/zgnykx-e201404026 https://doaj.org/article/8621a9edee064aa9a0b2ea5d40ba0811 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF5BJSQ4IF4VaaFaEAc4uPXaazs-lihVQdBLWqm31T5mQxRYp00iHgck_jkza8ekp17wyVrbI9sznvnGO_sNY29K0CBrXScgrUtk7YvECAJyxA7mKCIArXf-fFaeXsiPl8XlVqsvqglr6YHbF3eEiFvoGhwABk-ta52aDHThZGo0hrOY-GDM20qm2vXBBS1-oM5yiCHQ0Yj63_Kdo0k_-Fbk78o0H8okkit8acL0CkPGjSAVufwx9Hjd3ICh977r4HWYbsWjk0fsYQck-XH7AI_ZHQhP2IPj6XVHpgFP2Z_xj67MNfDGc6q6mEPg56j65NNsDhwxIyyo3Q7XwfHJbBolOt2OzQKfLKjSIh4dgV1_IzHRP2yELfmHWM0FjtMfXT6e0QyQ5ojEqazqGbs4GZ-PTpOu5UJi5VCsElMaYt9xWsjMugq3oQVnsyLXqYfKez9MTVkbzKqyCjMpkFVmpMiEzTzmQnm-y3ZCE-A548YiGizrQhuTS5tao0vcrWXmrEU34Adsr3_fatFSayhM14jPpxowuVGAsh1ZOfXM-Kr6qjTSoSIdKpGrqENVDthhf9lG5C0XvCft9icT2XYcQBNUnQmq20xwwHbRNpRGDS_V6AwhVZnTjD4-xauNuSj8amkqRgdo1ktq_kmpbZ3jHbzu7Eh13mOpfk3Dzzn6rSySH2GWvPc_bnOf3SeBbdnRC7azul7DS0RUK3PA7h7-FgfxE_oLNjMYPg |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Expression+of+Chicken+Toll-Like+Receptors+and+Signal+Adaptors+in+Spleen+and+Cecum+of+Young+Chickens+Infected+with+Eimeria+tenella&rft.jtitle=Journal+of+Integrative+Agriculture&rft.au=Zuo-yong+ZHOU&rft.au=Shi-jun+HU&rft.au=Zhi-ying+WANG&rft.au=Zhi-li+GUO&rft.date=2014-04-01&rft.pub=KeAi+Communications+Co.%2C+Ltd&rft.issn=2095-3119&rft.volume=13&rft.issue=4&rft.spage=904&rft.epage=910&rft_id=info:doi/10.1016%2FS2095-3119%2813%2960384-6&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_8621a9edee064aa9a0b2ea5d40ba0811 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F86610A%2F86610A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzgnykx-e%2Fzgnykx-e.jpg |