Over-expression of AQP7 contributes to improve insulin resistance in adipocytes

• Published in: Experimental cell research Vol. 318; no. 18; pp. 2377 - 2384
• Main Authors: Shen, Fei-Xia, Gu, Xuemei, Pan, Wei, Li, Wei-Ping, Li, Wei, Ye, Jing, Yang, Li-Juan, Gu, Xue-Jiang, Ni, Lian-Song
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2012; Elsevier BV
• Subjects: 3-Phosphoinositide-Dependent Protein Kinases; 3T3-L1 adipocytes; 3T3-L1 Cells; Adipocytes - cytology; Adipocytes - metabolism; Animals; Aquaglyceroporin 7 (AQP7); Aquaporins - genetics; Aquaporins - metabolism; Cell Differentiation; Cellular biology; Dexamethasone - pharmacology; Down-Regulation; Gene expression; Insulin resistance; Insulin Resistance - genetics; Mice; Phosphorylation; PKB; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Proteins; RNA, Messenger - metabolism; Tumor Necrosis Factor-alpha - metabolism; Insulin resistance; 3T3-L1 adipocytes; PKB; Aquaglyceroporin 7 (AQP7)

Aquaglyceroporin 7 (AQP7) is required for efflux of glycerol from adipocytes. In this study, we aimed to analyze expression profiles of AQP7 in the different differentiation phases of adipocytes and to investigate the role of AQP7 in the insulin resistance of adipocytes. Methods: 3T3-L1 pre-adipocyt...