Adjuvant potential of resiquimod with inactivated Newcastle disease vaccine and its mechanism of action in chicken

• Published in: Vaccine Vol. 33; no. 36; pp. 4526 - 4532
• Main Authors: Sachan, Swati, Ramakrishnan, Saravanan, Annamalai, Arunsaravanakumar, Sharma, Bal Krishan, Malik, Hina, Saravanan, B.C, Jain, Lata, Saxena, Meeta, Kumar, Ajay, Krishnaswamy, Narayanan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 26.08.2015; Elsevier Limited
• Subjects: Adjuvant; Adjuvants, Immunologic - administration & dosage; Allergy and Immunology; Animal vaccines; Animals; Antibodies, Viral - blood; Birds; Chicken; Chickens; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Profiling; Genes; Hemagglutination Inhibition Tests; Imidazoles - administration & dosage; Immune response; Immune response genes; Lymphocytes; Lymphocytes - immunology; Newcastle disease; Newcastle Disease - prevention & control; Newcastle disease virus; Poultry; Resiquimod; TLR agonist; Vaccines; Vaccines, Inactivated - administration & dosage; Viral Vaccines - administration & dosage; Newcastle disease; Immune response genes; Cytokines; TLR agonist; Resiquimod; Chicken; Adjuvant
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2015.07.016

Highlights • Resiquimod (R-848) showed potential adjuvant capacity with Newcastle disease (ND) vaccine in SPF chicken. • R-848 enhanced antigen specific humoral as well as cellular immune responses. • R-848 up-regulated the expression of IFN-α, IFN-β, IFN-γ, IL-4, IL-1β, MHC-II and iNOS transcripts in the chicken spleen. • R-848 potentiated the protection capacity of inactivated ND vaccine against virulent ND virus challenge.