Adjuvant potential of resiquimod with inactivated Newcastle disease vaccine and its mechanism of action in chicken
Highlights • Resiquimod (R-848) showed potential adjuvant capacity with Newcastle disease (ND) vaccine in SPF chicken. • R-848 enhanced antigen specific humoral as well as cellular immune responses. • R-848 up-regulated the expression of IFN-α, IFN-β, IFN-γ, IL-4, IL-1β, MHC-II and iNOS transcripts...
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Published in | Vaccine Vol. 33; no. 36; pp. 4526 - 4532 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
26.08.2015
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Resiquimod (R-848) showed potential adjuvant capacity with Newcastle disease (ND) vaccine in SPF chicken. • R-848 enhanced antigen specific humoral as well as cellular immune responses. • R-848 up-regulated the expression of IFN-α, IFN-β, IFN-γ, IL-4, IL-1β, MHC-II and iNOS transcripts in the chicken spleen. • R-848 potentiated the protection capacity of inactivated ND vaccine against virulent ND virus challenge. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2015.07.016 |