T Cells, Interleukin-2 and Systemic Lupus Erythematosus-From Pathophysiology to Therapy

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 6; p. 980
• Main Author: Mak, Anselm
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.03.2022; MDPI
• Subjects: Animal models; Animals; Antigens; Clinical trials; Cytokines; Gene expression; Humans; Inflammation; Interleukin 2; Kinases; Lipids; Lupus; Lupus Erythematosus, Systemic; Lymphocytes; Lymphocytes T; Metabolism; Mice; Pathophysiology; Phosphorylation; Proteins; regulatory; Review; Signal transduction; SLE; Systemic lupus erythematosus; T cell; T cell receptors; T-Lymphocytes, Regulatory; interleukin-2; SLE; lupus; T cell; regulatory

The phenotypic and functional complexities of T cells engender complicated and often confusing concepts as to how T cells ignite, accelerate and brake the inflammatory processes involved in systemic lupus erythematosus (SLE), let alone the plasticity of T cells that takes place under different immun...