Caveolin-1 promotes tumor growth and metastasis via autophagy inhibition in hepatocellular carcinoma
Caveolin-1 is a member of the caveolae family of membrane proteins. Although some researchers have investigated the function of Caveolin-1 in hepatocellular carcinoma, the mechanism of Caveolin-1 action and its prognostic value in hepatocellular carcinoma remain unclear. Caveolin-1 expression was me...
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| Published in | Clinics and research in hepatology and gastroenterology Vol. 40; no. 2; pp. 169 - 178 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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France
Elsevier Masson SAS
01.04.2016
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| Abstract | Caveolin-1 is a member of the caveolae family of membrane proteins. Although some researchers have investigated the function of Caveolin-1 in hepatocellular carcinoma, the mechanism of Caveolin-1 action and its prognostic value in hepatocellular carcinoma remain unclear.
Caveolin-1 expression was measured in hepatocellular carcinoma cell lines and tissues using quantitative reverse transcription-polymerase chain reaction, western blot, and immunofluorescence assays. In in vitro experiments, Caveolin-1 was depleted using a short hairpin RNA lentiviral vector, and tumor cell behavior was analyzed. The effect of Caveolin-1 on hepatocellular carcinoma cell autophagy was investigated. Prognostic value of Caveolin-1 was analyzed by immunohistochemistry in two cohorts that included a total of 721 hepatocellular carcinoma patients.
We found that Caveolin-1 was overexpressed in highly metastatic hepatocellular carcinoma cell lines and tumor tissues. Moreover, Caveolin-1 promoted hepatocellular carcinoma cell proliferation, migration, and angiogenesis and inhibited autophagy. Finally, Caveolin-1 expression in hepatocellular carcinoma tissues was inversely correlated with patient overall survival and time to recurrence.
Our data obtained from cell lines suggest an oncogenic role for Caveolin-1 in hepatocellular carcinoma, Caveolin-1 contributed to hepatocellular carcinoma cell autophagy deficiency. Furthermore, Caveolin-1 may function as a novel prognostic indicator for hepatocellular carcinoma patients after curative resection, and combination of targeted therapy aimed at Caveolin-1 and autophagy modulation may represent an effective way to treat hepatocellular carcinoma. |
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| AbstractList | Summary Background Caveolin-1 is a member of the caveolae family of membrane proteins. Although some researchers have investigated the function of Caveolin-1 in hepatocellular carcinoma, the mechanism of Caveolin-1 action and its prognostic value in hepatocellular carcinoma remain unclear. Methods Caveolin-1 expression was measured in hepatocellular carcinoma cell lines and tissues using quantitative reverse transcription-polymerase chain reaction, western blot, and immunofluorescence assays. In in vitro experiments, Caveolin-1 was depleted using a short hairpin RNA lentiviral vector, and tumor cell behavior was analyzed. The effect of Caveolin-1 on hepatocellular carcinoma cell autophagy was investigated. Prognostic value of Caveolin-1 was analyzed by immunohistochemistry in two cohorts that included a total of 721 hepatocellular carcinoma patients. Results We found that Caveolin-1 was overexpressed in highly metastatic hepatocellular carcinoma cell lines and tumor tissues. Moreover, Caveolin-1 promoted hepatocellular carcinoma cell proliferation, migration, and angiogenesis and inhibited autophagy. Finally, Caveolin-1 expression in hepatocellular carcinoma tissues was inversely correlated with patient overall survival and time to recurrence. Conclusion Our data obtained from cell lines suggest an oncogenic role for Caveolin-1 in hepatocellular carcinoma, Caveolin-1 contributed to hepatocellular carcinoma cell autophagy deficiency. Furthermore, Caveolin-1 may function as a novel prognostic indicator for hepatocellular carcinoma patients after curative resection, and combination of targeted therapy aimed at Caveolin-1 and autophagy modulation may represent an effective way to treat hepatocellular carcinoma. Caveolin-1 is a member of the caveolae family of membrane proteins. Although some researchers have investigated the function of Caveolin-1 in hepatocellular carcinoma, the mechanism of Caveolin-1 action and its prognostic value in hepatocellular carcinoma remain unclear. Caveolin-1 expression was measured in hepatocellular carcinoma cell lines and tissues using quantitative reverse transcription-polymerase chain reaction, western blot, and immunofluorescence assays. In in vitro experiments, Caveolin-1 was depleted using a short hairpin RNA lentiviral vector, and tumor cell behavior was analyzed. The effect of Caveolin-1 on hepatocellular carcinoma cell autophagy was investigated. Prognostic value of Caveolin-1 was analyzed by immunohistochemistry in two cohorts that included a total of 721 hepatocellular carcinoma patients. We found that Caveolin-1 was overexpressed in highly metastatic hepatocellular carcinoma cell lines and tumor tissues. Moreover, Caveolin-1 promoted hepatocellular carcinoma cell proliferation, migration, and angiogenesis and inhibited autophagy. Finally, Caveolin-1 expression in hepatocellular carcinoma tissues was inversely correlated with patient overall survival and time to recurrence. Our data obtained from cell lines suggest an oncogenic role for Caveolin-1 in hepatocellular carcinoma, Caveolin-1 contributed to hepatocellular carcinoma cell autophagy deficiency. Furthermore, Caveolin-1 may function as a novel prognostic indicator for hepatocellular carcinoma patients after curative resection, and combination of targeted therapy aimed at Caveolin-1 and autophagy modulation may represent an effective way to treat hepatocellular carcinoma. Caveolin-1 is a member of the caveolae family of membrane proteins. Although some researchers have investigated the function of Caveolin-1 in hepatocellular carcinoma, the mechanism of Caveolin-1 action and its prognostic value in hepatocellular carcinoma remain unclear.BACKGROUNDCaveolin-1 is a member of the caveolae family of membrane proteins. Although some researchers have investigated the function of Caveolin-1 in hepatocellular carcinoma, the mechanism of Caveolin-1 action and its prognostic value in hepatocellular carcinoma remain unclear.Caveolin-1 expression was measured in hepatocellular carcinoma cell lines and tissues using quantitative reverse transcription-polymerase chain reaction, western blot, and immunofluorescence assays. In in vitro experiments, Caveolin-1 was depleted using a short hairpin RNA lentiviral vector, and tumor cell behavior was analyzed. The effect of Caveolin-1 on hepatocellular carcinoma cell autophagy was investigated. Prognostic value of Caveolin-1 was analyzed by immunohistochemistry in two cohorts that included a total of 721 hepatocellular carcinoma patients.METHODSCaveolin-1 expression was measured in hepatocellular carcinoma cell lines and tissues using quantitative reverse transcription-polymerase chain reaction, western blot, and immunofluorescence assays. In in vitro experiments, Caveolin-1 was depleted using a short hairpin RNA lentiviral vector, and tumor cell behavior was analyzed. The effect of Caveolin-1 on hepatocellular carcinoma cell autophagy was investigated. Prognostic value of Caveolin-1 was analyzed by immunohistochemistry in two cohorts that included a total of 721 hepatocellular carcinoma patients.We found that Caveolin-1 was overexpressed in highly metastatic hepatocellular carcinoma cell lines and tumor tissues. Moreover, Caveolin-1 promoted hepatocellular carcinoma cell proliferation, migration, and angiogenesis and inhibited autophagy. Finally, Caveolin-1 expression in hepatocellular carcinoma tissues was inversely correlated with patient overall survival and time to recurrence.RESULTSWe found that Caveolin-1 was overexpressed in highly metastatic hepatocellular carcinoma cell lines and tumor tissues. Moreover, Caveolin-1 promoted hepatocellular carcinoma cell proliferation, migration, and angiogenesis and inhibited autophagy. Finally, Caveolin-1 expression in hepatocellular carcinoma tissues was inversely correlated with patient overall survival and time to recurrence.Our data obtained from cell lines suggest an oncogenic role for Caveolin-1 in hepatocellular carcinoma, Caveolin-1 contributed to hepatocellular carcinoma cell autophagy deficiency. Furthermore, Caveolin-1 may function as a novel prognostic indicator for hepatocellular carcinoma patients after curative resection, and combination of targeted therapy aimed at Caveolin-1 and autophagy modulation may represent an effective way to treat hepatocellular carcinoma.CONCLUSIONOur data obtained from cell lines suggest an oncogenic role for Caveolin-1 in hepatocellular carcinoma, Caveolin-1 contributed to hepatocellular carcinoma cell autophagy deficiency. Furthermore, Caveolin-1 may function as a novel prognostic indicator for hepatocellular carcinoma patients after curative resection, and combination of targeted therapy aimed at Caveolin-1 and autophagy modulation may represent an effective way to treat hepatocellular carcinoma. |
| Author | Zhou, Jian Jiang, Xi-Fei Fan, Jia Liu, Wei-Ren Gao, Dong-Mei Dai, Zhi Yang, Liu-Xiao Qiu, Shuang-Jian Shi, Ying-Hong Peng, Yuan-Fei Jin, Lei Tian, Meng-Xin Shen, Ying-Hao Ding, Zhen-Bin |
| Author_xml | – sequence: 1 givenname: Wei-Ren surname: Liu fullname: Liu, Wei-Ren organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 2 givenname: Lei surname: Jin fullname: Jin, Lei organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 3 givenname: Meng-Xin surname: Tian fullname: Tian, Meng-Xin organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 4 givenname: Xi-Fei surname: Jiang fullname: Jiang, Xi-Fei organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 5 givenname: Liu-Xiao surname: Yang fullname: Yang, Liu-Xiao organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 6 givenname: Zhen-Bin surname: Ding fullname: Ding, Zhen-Bin organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 7 givenname: Ying-Hao surname: Shen fullname: Shen, Ying-Hao organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 8 givenname: Yuan-Fei surname: Peng fullname: Peng, Yuan-Fei organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 9 givenname: Dong-Mei surname: Gao fullname: Gao, Dong-Mei organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 10 givenname: Jian surname: Zhou fullname: Zhou, Jian organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 11 givenname: Shuang-Jian surname: Qiu fullname: Qiu, Shuang-Jian organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 12 givenname: Zhi surname: Dai fullname: Dai, Zhi organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 13 givenname: Jia surname: Fan fullname: Fan, Jia organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China – sequence: 14 givenname: Ying-Hong surname: Shi fullname: Shi, Ying-Hong email: shi.yinghong@zs-hospital.sh.cn organization: Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180, FengLin Road, 200032 Shanghai, China |
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| Cites_doi | 10.3322/caac.20107 10.1158/0008-5472.CAN-11-3102 10.1038/nm843 10.4161/cc.10.24.18551 10.1002/hep.22393 10.4161/cc.9.21.13817 10.1016/j.biocel.2011.01.023 10.1007/s00432-004-0564-9 10.1158/0008-5472.CAN-12-0777 10.1158/0008-5472.CAN-10-4249 10.4161/auto.7.10.16818 10.1016/j.bbrc.2006.03.246 10.1158/1078-0432.CCR-12-0183 10.1146/annurev-pathol-011811-120856 10.3389/fphys.2011.00120 10.1016/j.cell.2011.05.040 10.1038/onc.2011.154 10.1158/0008-5472.CAN-12-0448 10.1016/S0140-6736(11)61347-0 10.1016/j.febslet.2013.02.002 10.1007/s12032-011-9900-5 10.1016/j.ejca.2013.08.016 10.1158/0008-5472.CAN-12-3040 10.1016/S1937-6448(08)01804-2 10.3109/00313025.2010.494293 10.1002/path.3957 10.1200/JCO.2006.09.4565 10.1186/1471-2407-9-65 10.1056/NEJMcibr1114526 |
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| Keywords | Cav-1 TNM TTR OS CI qRT-PCR γ-GT HCC TMA HR AFP EMT Caveolin-1 Quantitative reverse transcription-polymerase chain reaction Confidential interval Hepatocellular carcinoma Time to recurrence Tissue microarray Hazard ratio Epithelial-to-mesenchymal transition γ-glutamyl transferase α-fetoprotein Overall survival Tumor-nodes-metastasis |
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| References | Gao, Qiu, Fan, Zhou, Wang, Xiao (bib0240) 2007; 25 Huang, Ding, Gu, Zhou, Kuang, Ji (bib0250) 2012; 18 Yu, Fan, Liu, Zhang, Wang, Zhang (bib0195) 2013; 587 Wu, Queenan, Brody, Potoczek, Sotgia, Lisanti (bib0185) 2011; 10 Chiu, Lee, Huang, Aldape, Yao, Steeg (bib0190) 2011; 71 Yang, Yang, Huang, Wang, Lu, Tsai (bib0215) 2010; 42 Jemal, Bray, Center, Ferlay, Ward, Forman (bib0150) 2011; 61 Du, Qian, Papageorge, Schetter, Vass, Liu (bib0205) 2012; 72 Zhou, Jia, Wang, Wang, Chu, Hu (bib0255) 2006; 345 Tahir, Yang, Goltsov, Song, Ren, Wang (bib0175) 2013; 73 Martinez-Outschoorn, Whitaker-Menezes, Pavlides, Chiavarina, Bonuccelli, Casey (bib0285) 2010; 9 Forner, Llovet, Bruix (bib0155) 2012; 379 Tse, Ko, Tung, Chan, Lee, Ngan (bib0200) 2012; 226 Kannan, Krishnan, Ali, Subramaniam, Halagowder, Sivasithamparam (bib0170) 2014; 50 Ha, Her, Lee, Ryu, Lee, Han (bib0270) 2012; 72 Li, Tian, Yang, Zhao, Wu, Ye (bib0220) 2004; 130 Martinez-Outschoorn, Pavlides, Howell, Pestell, Tanowitz, Sotgia (bib0280) 2011; 43 Cokakli, Erdal, Nart, Yilmaz, Sagol, Kilic (bib0260) 2009; 9 Shi, Ding, Zhou, He, Xu, Gambotto (bib0245) 2008; 48 Sotgia, Martinez-Outschoorn, Howell, Pestell, Pavlides, Lisanti (bib0275) 2012; 7 Tang, Zeng, He, Liao, Qian, Toi (bib0210) 2012; 29 Ye, Qin, Forgues, He, Kim, Peng (bib0225) 2003; 9 Parat (bib0165) 2009; 273 Goetz, Minguet, Navarro-Lerida, Lazcano, Samaniego, Calvo (bib0290) 2011; 146 Sowa (bib0160) 2012; 2 Weiner, Lotze (bib0265) 2012; 366 Shi, Ding, Zhou, Hui, Shi, Ke (bib0230) 2011; 7 Huang, Qiu, Wang, Peng, Jia, Logsdon (bib0180) 2012; 72 Jiang, Liu, Guo, Zhang, Zhi, Ji (bib0235) 2011; 30 Tahir (10.1016/j.clinre.2015.06.017_bib0175) 2013; 73 Jemal (10.1016/j.clinre.2015.06.017_bib0150) 2011; 61 Ye (10.1016/j.clinre.2015.06.017_bib0225) 2003; 9 Zhou (10.1016/j.clinre.2015.06.017_bib0255) 2006; 345 Li (10.1016/j.clinre.2015.06.017_bib0220) 2004; 130 Cokakli (10.1016/j.clinre.2015.06.017_bib0260) 2009; 9 Sotgia (10.1016/j.clinre.2015.06.017_bib0275) 2012; 7 Shi (10.1016/j.clinre.2015.06.017_bib0230) 2011; 7 Parat (10.1016/j.clinre.2015.06.017_bib0165) 2009; 273 Gao (10.1016/j.clinre.2015.06.017_bib0240) 2007; 25 Forner (10.1016/j.clinre.2015.06.017_bib0155) 2012; 379 Sowa (10.1016/j.clinre.2015.06.017_bib0160) 2012; 2 Ha (10.1016/j.clinre.2015.06.017_bib0270) 2012; 72 Huang (10.1016/j.clinre.2015.06.017_bib0250) 2012; 18 Chiu (10.1016/j.clinre.2015.06.017_bib0190) 2011; 71 Du (10.1016/j.clinre.2015.06.017_bib0205) 2012; 72 Tse (10.1016/j.clinre.2015.06.017_bib0200) 2012; 226 Yu (10.1016/j.clinre.2015.06.017_bib0195) 2013; 587 Yang (10.1016/j.clinre.2015.06.017_bib0215) 2010; 42 Shi (10.1016/j.clinre.2015.06.017_bib0245) 2008; 48 Goetz (10.1016/j.clinre.2015.06.017_bib0290) 2011; 146 Tang (10.1016/j.clinre.2015.06.017_bib0210) 2012; 29 Martinez-Outschoorn (10.1016/j.clinre.2015.06.017_bib0285) 2010; 9 Huang (10.1016/j.clinre.2015.06.017_bib0180) 2012; 72 Jiang (10.1016/j.clinre.2015.06.017_bib0235) 2011; 30 Weiner (10.1016/j.clinre.2015.06.017_bib0265) 2012; 366 Kannan (10.1016/j.clinre.2015.06.017_bib0170) 2014; 50 Wu (10.1016/j.clinre.2015.06.017_bib0185) 2011; 10 Martinez-Outschoorn (10.1016/j.clinre.2015.06.017_bib0280) 2011; 43 |
| References_xml | – volume: 48 start-page: 497 year: 2008 end-page: 507 ident: bib0245 article-title: Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence publication-title: Hepatology – volume: 43 start-page: 1045 year: 2011 end-page: 1051 ident: bib0280 article-title: Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment publication-title: Int J Biochem Cell Biol – volume: 18 start-page: 3042 year: 2012 end-page: 3053 ident: bib0250 article-title: Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1alpha to promote hepatocellular carcinoma invasiveness publication-title: Clin Cancer Res – volume: 9 start-page: 65 year: 2009 ident: bib0260 article-title: Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion publication-title: BMC Cancer – volume: 7 start-page: 423 year: 2012 end-page: 467 ident: bib0275 article-title: Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms publication-title: Annu Rev Pathol – volume: 61 start-page: 69 year: 2011 end-page: 90 ident: bib0150 article-title: Global cancer statistics publication-title: CA Cancer J Clin – volume: 587 start-page: 782 year: 2013 end-page: 787 ident: bib0195 article-title: Caveolin-1 up-regulates integrin alpha2,6-sialylation to promote integrin alpha5beta1-dependent hepatocarcinoma cell adhesion publication-title: FEBS Lett – volume: 50 start-page: 204 year: 2014 end-page: 215 ident: bib0170 article-title: Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition publication-title: Eur J Cancer – volume: 73 start-page: 1900 year: 2013 end-page: 1911 ident: bib0175 article-title: Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer publication-title: Cancer Res – volume: 146 start-page: 148 year: 2011 end-page: 163 ident: bib0290 article-title: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis publication-title: Cell – volume: 9 start-page: 4297 year: 2010 end-page: 4306 ident: bib0285 article-title: The autophagic tumor stroma model of cancer or “battery-operated tumor growth”: a simple solution to the autophagy paradox publication-title: Cell Cycle – volume: 42 start-page: 438 year: 2010 end-page: 445 ident: bib0215 article-title: Increased caveolin-1 expression associated with prolonged overall survival rate in hepatocellular carcinoma publication-title: Pathology – volume: 72 start-page: 4405 year: 2012 end-page: 4416 ident: bib0205 article-title: Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells publication-title: Cancer Res – volume: 25 start-page: 2586 year: 2007 end-page: 2593 ident: bib0240 article-title: Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection publication-title: J Clin Oncol – volume: 366 start-page: 1156 year: 2012 end-page: 1158 ident: bib0265 article-title: Tumor-cell death, autophagy, and immunity publication-title: N Engl J Med – volume: 72 start-page: 4097 year: 2012 end-page: 4109 ident: bib0270 article-title: Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription publication-title: Cancer Res – volume: 72 start-page: 655 year: 2012 end-page: 665 ident: bib0180 article-title: A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis publication-title: Cancer Res – volume: 10 start-page: 4250 year: 2011 end-page: 4255 ident: bib0185 article-title: Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival publication-title: Cell Cycle – volume: 345 start-page: 486 year: 2006 end-page: 494 ident: bib0255 article-title: Divergent expression and roles for caveolin-1 in mouse hepatocarcinoma cell lines with varying invasive ability publication-title: Biochem Biophys Res Commun – volume: 71 start-page: 4932 year: 2011 end-page: 4943 ident: bib0190 article-title: Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition publication-title: Cancer Res – volume: 130 start-page: 460 year: 2004 end-page: 468 ident: bib0220 article-title: Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics publication-title: J Cancer Res Clin Oncol – volume: 379 start-page: 1245 year: 2012 end-page: 1255 ident: bib0155 article-title: Hepatocellular carcinoma publication-title: Lancet – volume: 226 start-page: 645 year: 2012 end-page: 653 ident: bib0200 article-title: Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis publication-title: J Pathol – volume: 7 start-page: 1159 year: 2011 end-page: 1172 ident: bib0230 article-title: Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis publication-title: Autophagy – volume: 9 start-page: 416 year: 2003 end-page: 423 ident: bib0225 article-title: Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning publication-title: Nat Med – volume: 2 start-page: 120 year: 2012 ident: bib0160 article-title: Caveolae, caveolins, cavins, and endothelial cell function: new insights publication-title: Front Physiol – volume: 273 start-page: 117 year: 2009 end-page: 162 ident: bib0165 article-title: The biology of caveolae: achievements and perspectives publication-title: Int Rev Cell Mol Biol – volume: 30 start-page: 4498 year: 2011 end-page: 4508 ident: bib0235 article-title: IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer publication-title: Oncogene – volume: 29 start-page: 977 year: 2012 end-page: 984 ident: bib0210 article-title: Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer publication-title: Med Oncol – volume: 61 start-page: 69 year: 2011 ident: 10.1016/j.clinre.2015.06.017_bib0150 article-title: Global cancer statistics publication-title: CA Cancer J Clin doi: 10.3322/caac.20107 – volume: 72 start-page: 655 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0180 article-title: A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-3102 – volume: 9 start-page: 416 year: 2003 ident: 10.1016/j.clinre.2015.06.017_bib0225 article-title: Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning publication-title: Nat Med doi: 10.1038/nm843 – volume: 10 start-page: 4250 year: 2011 ident: 10.1016/j.clinre.2015.06.017_bib0185 article-title: Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival publication-title: Cell Cycle doi: 10.4161/cc.10.24.18551 – volume: 48 start-page: 497 year: 2008 ident: 10.1016/j.clinre.2015.06.017_bib0245 article-title: Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence publication-title: Hepatology doi: 10.1002/hep.22393 – volume: 9 start-page: 4297 year: 2010 ident: 10.1016/j.clinre.2015.06.017_bib0285 article-title: The autophagic tumor stroma model of cancer or “battery-operated tumor growth”: a simple solution to the autophagy paradox publication-title: Cell Cycle doi: 10.4161/cc.9.21.13817 – volume: 43 start-page: 1045 year: 2011 ident: 10.1016/j.clinre.2015.06.017_bib0280 article-title: Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2011.01.023 – volume: 130 start-page: 460 year: 2004 ident: 10.1016/j.clinre.2015.06.017_bib0220 article-title: Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics publication-title: J Cancer Res Clin Oncol doi: 10.1007/s00432-004-0564-9 – volume: 72 start-page: 4405 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0205 article-title: Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-0777 – volume: 71 start-page: 4932 year: 2011 ident: 10.1016/j.clinre.2015.06.017_bib0190 article-title: Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-4249 – volume: 7 start-page: 1159 year: 2011 ident: 10.1016/j.clinre.2015.06.017_bib0230 article-title: Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis publication-title: Autophagy doi: 10.4161/auto.7.10.16818 – volume: 345 start-page: 486 year: 2006 ident: 10.1016/j.clinre.2015.06.017_bib0255 article-title: Divergent expression and roles for caveolin-1 in mouse hepatocarcinoma cell lines with varying invasive ability publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2006.03.246 – volume: 18 start-page: 3042 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0250 article-title: Decreased selenium-binding protein 1 enhances glutathione peroxidase 1 activity and downregulates HIF-1alpha to promote hepatocellular carcinoma invasiveness publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-12-0183 – volume: 7 start-page: 423 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0275 article-title: Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms publication-title: Annu Rev Pathol doi: 10.1146/annurev-pathol-011811-120856 – volume: 2 start-page: 120 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0160 article-title: Caveolae, caveolins, cavins, and endothelial cell function: new insights publication-title: Front Physiol doi: 10.3389/fphys.2011.00120 – volume: 146 start-page: 148 year: 2011 ident: 10.1016/j.clinre.2015.06.017_bib0290 article-title: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis publication-title: Cell doi: 10.1016/j.cell.2011.05.040 – volume: 30 start-page: 4498 year: 2011 ident: 10.1016/j.clinre.2015.06.017_bib0235 article-title: IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer publication-title: Oncogene doi: 10.1038/onc.2011.154 – volume: 72 start-page: 4097 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0270 article-title: Caveolin-1 increases aerobic glycolysis in colorectal cancers by stimulating HMGA1-mediated GLUT3 transcription publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-0448 – volume: 379 start-page: 1245 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0155 article-title: Hepatocellular carcinoma publication-title: Lancet doi: 10.1016/S0140-6736(11)61347-0 – volume: 587 start-page: 782 year: 2013 ident: 10.1016/j.clinre.2015.06.017_bib0195 article-title: Caveolin-1 up-regulates integrin alpha2,6-sialylation to promote integrin alpha5beta1-dependent hepatocarcinoma cell adhesion publication-title: FEBS Lett doi: 10.1016/j.febslet.2013.02.002 – volume: 29 start-page: 977 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0210 article-title: Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer publication-title: Med Oncol doi: 10.1007/s12032-011-9900-5 – volume: 50 start-page: 204 year: 2014 ident: 10.1016/j.clinre.2015.06.017_bib0170 article-title: Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition publication-title: Eur J Cancer doi: 10.1016/j.ejca.2013.08.016 – volume: 73 start-page: 1900 year: 2013 ident: 10.1016/j.clinre.2015.06.017_bib0175 article-title: Caveolin-1-LRP6 signaling module stimulates aerobic glycolysis in prostate cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-3040 – volume: 273 start-page: 117 year: 2009 ident: 10.1016/j.clinre.2015.06.017_bib0165 article-title: The biology of caveolae: achievements and perspectives publication-title: Int Rev Cell Mol Biol doi: 10.1016/S1937-6448(08)01804-2 – volume: 42 start-page: 438 year: 2010 ident: 10.1016/j.clinre.2015.06.017_bib0215 article-title: Increased caveolin-1 expression associated with prolonged overall survival rate in hepatocellular carcinoma publication-title: Pathology doi: 10.3109/00313025.2010.494293 – volume: 226 start-page: 645 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0200 article-title: Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis publication-title: J Pathol doi: 10.1002/path.3957 – volume: 25 start-page: 2586 year: 2007 ident: 10.1016/j.clinre.2015.06.017_bib0240 article-title: Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection publication-title: J Clin Oncol doi: 10.1200/JCO.2006.09.4565 – volume: 9 start-page: 65 year: 2009 ident: 10.1016/j.clinre.2015.06.017_bib0260 article-title: Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion publication-title: BMC Cancer doi: 10.1186/1471-2407-9-65 – volume: 366 start-page: 1156 year: 2012 ident: 10.1016/j.clinre.2015.06.017_bib0265 article-title: Tumor-cell death, autophagy, and immunity publication-title: N Engl J Med doi: 10.1056/NEJMcibr1114526 |
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| Snippet | Caveolin-1 is a member of the caveolae family of membrane proteins. Although some researchers have investigated the function of Caveolin-1 in hepatocellular... Summary Background Caveolin-1 is a member of the caveolae family of membrane proteins. Although some researchers have investigated the function of Caveolin-1... |
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| SubjectTerms | Autophagy - physiology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - secondary Caveolin 1 - biosynthesis Caveolin 1 - physiology Cell Proliferation Female Gastroenterology and Hepatology Humans Internal Medicine Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Middle Aged Prognosis Tumor Cells, Cultured |
| Title | Caveolin-1 promotes tumor growth and metastasis via autophagy inhibition in hepatocellular carcinoma |
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