PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

• Published in: The Journal of experimental medicine Vol. 207; no. 9; pp. 1853 - 1862
• Main Authors: Li, Pingxin, Li, Ming, Lindberg, Michael R., Kennett, Mary J., Xiong, Na, Wang, Yanming
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 30.08.2010
• Subjects: Animals; Brief Definitive Report; Cell Differentiation; Dysentery, Bacillary - immunology; Extracellular Space - immunology; Extracellular Space - metabolism; Histones - metabolism; Hydrolases - deficiency; Hydrolases - immunology; Hydrolases - metabolism; Immunity, Innate; Mice; Mice, Knockout; Neutrophils - cytology; Neutrophils - immunology; Neutrophils - metabolism; Shigella flexneri - immunology

Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs). We previously reported that histone hypercitrullination catalyzed by peptidylarginine deiminase 4 (PAD4) correlates with chromatin decondensation during NET formation....