Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

• Published in: The Journal of cell biology Vol. 217; no. 6; pp. 1915 - 1928
• Main Authors: Wang, Ying, Branicky, Robyn, Noë, Alycia, Hekimi, Siegfried
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.06.2018
• Subjects: Animals; Anions; Diffusion rate; Disease; Electron transport; Enzymes; Free radicals; Humans; Hydrogen peroxide; Mitochondria; Models, Animal; Organisms; Oxidation; Oxidation-Reduction; Oxygen; Proteins; Reactive nitrogen species; Reactive oxygen species; Reactive Oxygen Species - metabolism; Reviews; Signal Transduction; Signaling; Substrates; Superoxide; Superoxide anions; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Toxicity

Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen peroxide. Superoxide anions are the intended product of dedicated signaling enzymes as well as the byproduct of several metabolic p...