Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD

• Published in: Biochemical journal Vol. 371; no. Pt 3; pp. 1045 - 1053
• Main Authors: Heiner, Inka, Eisfeld, Jörg, Halaszovich, Christian R, Wehage, Edith, Jüngling, Eberhard, Zitt, Christof, Lückhoff, Andreas
• Format: Journal Article
• Language: English
• Published: England 01.05.2003
• Subjects: Adenosine Diphosphate Ribose - pharmacology; Base Sequence; Calcium Channels - drug effects; Calcium Channels - genetics; Calcium Channels - physiology; Cell Line; DNA Primers; Gene Expression Profiling; Humans; Ion Channels; Membrane Proteins; NAD - pharmacology; Neutrophils - drug effects; Neutrophils - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; TRPC Cation Channels; TRPM Cation Channels

An early key event in the activation of neutrophil granulocytes is Ca(2+) influx. Members of the transient receptor potential (TRP) channel family may be held responsible for this. The aim of the present study is to analyse the expression pattern of TRP mRNA and identify characteristic currents unam...