Studies of Mercaptosuccinic Acid-Crosslinked Chitosan Hydrogel with Grafted Cinnamaldehyde and Silver Nanoparticles for Antibacterial Biomedical Application

• Published in: International journal of molecular sciences Vol. 23; no. 23; p. 14806
• Main Authors: Cheng, Chi-Hui, Tu, Yao-Yuan, Lin, Jui-Che
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.11.2022; MDPI
• Subjects: Acids; Amines; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antiinfectives and antibacterials; Antimicrobial agents; antimicrobial properties; Biocompatibility; Biomaterials; Biomedical materials; chemical crosslinking; Chitosan; Chitosan - chemistry; Cinnamaldehyde; Compressive strength; Crosslinking; Cytotoxicity; Drug resistance; Equilibrium; Grafting; Hydrocarbons; Hydrogels; Hydrogels - chemistry; Mechanical properties; Metal Nanoparticles - chemistry; Nanoparticles; NMR; Nuclear magnetic resonance; Protonation; Silver; Silver - chemistry; Spectrum analysis; Thiomalates; Wound healing; chitosan; antimicrobial properties; cinnamaldehyde; chemical crosslinking; cytotoxicity

For the effective clinical antibacterial application of biomaterials, such as for wound management and tissue repair, the biomaterials need to show proper antibacterial capability as well as non-cytotoxicity. Furthermore, the material needs to have suitable mechanical characteristics for further med...