Activation and signaling of the p38 MAP kinase pathway

• Published in: Cell research Vol. 15; no. 1; pp. 11 - 18
• Main Authors: ZARUBIN, Tyler, HAN, Jiahuai
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 2005; Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
• Subjects: Animals; Apoptosis; Cell Differentiation; Cellular Senescence; Down-Regulation; Enzyme Activation; Humans; Inflammation - pathology; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases - metabolism; p38MAP激酶; Protein Isoforms; Protein Kinases - metabolism; Signal Transduction; Time Factors; Transcription, Genetic; Upstream; 活化作用; 细胞信号转导路径; 细胞分化; 细胞衰老; 肿瘤发生; senescence; p38 MAP kinase; nexus; differentiation; inflammation; signaling pathway; tumorigenesis

The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological pr...