The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats
Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications....
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| Published in | Integrative medicine research Vol. 6; no. 4; pp. 354 - 360 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.12.2017
Elsevier 한국한의학연구원 |
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| Abstract | Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications.
Diabetes was induced via administration of alloxan (150mg/kg, intraperitoneally). Rats (n=8) were treated with pomegranate juice (PJ) [3mL/animal, per os (p.o.)], TOL (20mg/kg, p.o.), and their combination for 4 weeks. Twenty-four hours after the last treatment, the pharmacodynamic interaction of PJ and TOL was evaluated by antinociceptive activity, electrocardiographic parameters, serum glucose, biomarkers, and lipid profile values. The influence of PJ on the pharmacokinetics of TOL was studied using the high performance liquid chromatography method.
The combination of PJ and TOL resulted in a significant improvement against diabetic complications compared to the group treated with TOL alone. The combination group was found to be the best protective group by significant improvement of antinociceptive activity, restoration of electrocardiographic parameters, serum glucose, biomarkers, and lipid profile compared to the group treated with TOL alone. Results of the pharmacokinetic study revealed that PJ increases bioavailability and half-life, along with a decrease in clearance and elimination rate of TOL.
From this study, it can be concluded that the combination of PJ and TOL exhibited profound protection compared to TOL alone against diabetic complications. The findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction. |
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| AbstractList | Background: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications. Methods: Diabetes was induced via administration of alloxan (150 mg/kg, intraperitoneally). Rats (n = 8) were treated with pomegranate juice (PJ) [3 mL/animal, per os (p.o.)], TOL (20 mg/kg, p.o.), and their combination for 4 weeks. Twenty-four hours after the last treatment, the pharmacodynamic interaction of PJ and TOL was evaluated by antinociceptive activity, electrocardiographic parameters, serum glucose, biomarkers, and lipid profile values. The influence of PJ on the pharmacokinetics of TOL was studied using the high performance liquid chromatography method. Results: The combination of PJ and TOL resulted in a significant improvement against diabetic complications compared to the group treated with TOL alone. The combination group was found to be the best protective group by significant improvement of antinociceptive activity, restoration of electrocardiographic parameters, serum glucose, biomarkers, and lipid profile compared to the group treated with TOL alone. Results of the pharmacokinetic study revealed that PJ increases bioavailability and half-life, along with a decrease in clearance and elimination rate of TOL. Conclusion: From this study, it can be concluded that the combination of PJ and TOL exhibited profound protection compared to TOL alone against diabetic complications. The findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction. Keywords: diabetes-induced complications, interaction, pomegranate juice, tolbutamide Background: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications. Methods: Diabetes was induced via administration of alloxan (150 mg/kg, intraperitoneally). Rats (n = 8) were treated with pomegranate juice (PJ) [3 mL/animal, per os (p.o.)], TOL (20 mg/kg, p.o.), and their combination for 4 weeks. Twenty-four hours after the last treatment, the pharmacodynamic interaction of PJ and TOL was evaluated by antinociceptive activity, electrocardiographic parameters, serum glucose, biomarkers, and lipid profile values. The influence of PJ on the pharmacokinetics of TOL was studied using the high performance liquid chromatography method. Results: The combination of PJ and TOL resulted in a significant improvement against diabetic complications compared to the group treated with TOL alone. The combination group was found to be the best protective group by significant improvement of antinociceptive activity, restoration of electrocardiographic parameters, serum glucose, biomarkers, and lipid profile compared to the group treated with TOL alone. Results of the pharmacokinetic study revealed that PJ increases bioavailability and half-life, along with a decrease in clearance and elimination rate of TOL. Conclusion: From this study, it can be concluded that the combination of PJ and TOL exhibited profound protection compared to TOL alone against diabetic complications. The findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction. KCI Citation Count: 7 Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications. Diabetes was induced via administration of alloxan (150mg/kg, intraperitoneally). Rats (n=8) were treated with pomegranate juice (PJ) [3mL/animal, per os (p.o.)], TOL (20mg/kg, p.o.), and their combination for 4 weeks. Twenty-four hours after the last treatment, the pharmacodynamic interaction of PJ and TOL was evaluated by antinociceptive activity, electrocardiographic parameters, serum glucose, biomarkers, and lipid profile values. The influence of PJ on the pharmacokinetics of TOL was studied using the high performance liquid chromatography method. The combination of PJ and TOL resulted in a significant improvement against diabetic complications compared to the group treated with TOL alone. The combination group was found to be the best protective group by significant improvement of antinociceptive activity, restoration of electrocardiographic parameters, serum glucose, biomarkers, and lipid profile compared to the group treated with TOL alone. Results of the pharmacokinetic study revealed that PJ increases bioavailability and half-life, along with a decrease in clearance and elimination rate of TOL. From this study, it can be concluded that the combination of PJ and TOL exhibited profound protection compared to TOL alone against diabetic complications. The findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction. Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications. Diabetes was induced via administration of alloxan (150 mg/kg, intraperitoneally). Rats ( = 8) were treated with pomegranate juice (PJ) [3 mL/animal, per os (p.o.)], TOL (20 mg/kg, p.o.), and their combination for 4 weeks. Twenty-four hours after the last treatment, the pharmacodynamic interaction of PJ and TOL was evaluated by antinociceptive activity, electrocardiographic parameters, serum glucose, biomarkers, and lipid profile values. The influence of PJ on the pharmacokinetics of TOL was studied using the high performance liquid chromatography method. The combination of PJ and TOL resulted in a significant improvement against diabetic complications compared to the group treated with TOL alone. The combination group was found to be the best protective group by significant improvement of antinociceptive activity, restoration of electrocardiographic parameters, serum glucose, biomarkers, and lipid profile compared to the group treated with TOL alone. Results of the pharmacokinetic study revealed that PJ increases bioavailability and half-life, along with a decrease in clearance and elimination rate of TOL. From this study, it can be concluded that the combination of PJ and TOL exhibited profound protection compared to TOL alone against diabetic complications. The findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction. |
| Author | Bhattacharjee, Ananya Chakraborty, Manodeep Ahmed, Mohammed Gulzar |
| AuthorAffiliation | b Pharmaceutics Department, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India a Pharmacology Department, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India c Pharmacology Department, Srinivas College of Pharmacy, Mangalore 574143, India |
| AuthorAffiliation_xml | – name: c Pharmacology Department, Srinivas College of Pharmacy, Mangalore 574143, India – name: a Pharmacology Department, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India – name: b Pharmaceutics Department, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India |
| Author_xml | – sequence: 1 givenname: Manodeep surname: Chakraborty fullname: Chakraborty, Manodeep email: manodeep.chakraborty@gmail.com organization: Pharmacology Department, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India – sequence: 2 givenname: Mohammed Gulzar surname: Ahmed fullname: Ahmed, Mohammed Gulzar organization: Pharmaceutics Department, Yenepoya Pharmacy College and Research Centre, Mangalore 575018, India – sequence: 3 givenname: Ananya surname: Bhattacharjee fullname: Bhattacharjee, Ananya organization: Pharmacology Department, Srinivas College of Pharmacy, Mangalore 574143, India |
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| CitedBy_id | crossref_primary_10_1021_acsanm_2c02149 crossref_primary_10_1016_j_jaim_2022_100633 crossref_primary_10_1089_jmf_2019_0069 crossref_primary_10_3390_antiox11030553 crossref_primary_10_1007_s40005_019_00440_4 crossref_primary_10_1016_j_synres_2020_100062 crossref_primary_10_1016_j_ejphar_2019_172625 |
| Cites_doi | 10.1055/s-0028-1095119 10.1016/j.nutres.2013.03.003 10.1097/00005344-199000169-00002 10.2478/v10102-012-0003-8 10.1089/jmf.2006.290 10.1124/dmd.106.011718 10.1016/S0140-6736(81)90061-1 10.1155/2016/2848759 10.4103/2231-4040.137428 10.1016/j.amjcard.2005.05.026 10.4103/0253-7613.201015 10.1016/S0378-5173(00)00445-2 10.4103/0253-7613.93853 10.3109/13880209.2014.900809 10.1111/j.1753-4887.2008.00133.x 10.4103/0253-7613.169577 10.4103/0250-474X.41462 10.1007/s00125-007-0886-7 10.1097/JCN.0b013e31827f174c 10.1161/CIRCRESAHA.110.223545 10.1111/j.1476-5381.2011.01369.x 10.1155/2017/5439645 10.4103/0976-9668.149085 10.4103/0250-474X.100235 10.1586/erc.09.154 |
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| Keywords | interaction pomegranate juice diabetes-induced complications tolbutamide |
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| Snippet | Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken... Background: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was... |
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| SubjectTerms | diabetes-induced complications interaction Original pomegranate juice tolbutamide 학제간연구 |
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| Title | The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats |
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