Rhinovirus Infection Increases 5-Lipoxygenase and Cyclooxygenase-2 in Bronchial Biopsy Specimens from Nonatopic Subjects
Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these symptoms, bronchial biopsy specimens from 9 normal subjects (nonatopic and with no history of chronic lung disease) were immunostained for 5...
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| Published in | The Journal of infectious diseases Vol. 185; no. 4; pp. 540 - 544 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chicago, IL
The University of Chicago Press
15.02.2002
University of Chicago Press Oxford University Press |
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| Abstract | Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these symptoms, bronchial biopsy specimens from 9 normal subjects (nonatopic and with no history of chronic lung disease) were immunostained for 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathway enzymes 2 weeks before and 4 days after experimental infection with human rhinovirus serotype 16.5-LO-positive cell counts increased 9-fold (from 0.48 to 4.4 cells/mm2; P <.05), and 5- LO-activating protein (FLAP)-positive cell counts increased 3.6-fold (from 1.8 to 6.5 cells/ mm2; P = .09). Levels of leukotriene A4 hydrolase and leukotriene C4 synthase were unchanged. COX-2-positive cell counts increased from 0 to 2.6 cells/mm2 (P = .009), with no change in COX-1 levels. Increases of 3-4-fold were seen in levels of macrophages (P = .02) and mast cells (P = .07) but not of eosinophils (P > .4), and bronchoalveolar lavage fluid cysteinyl-leukotriene levels doubled (from 11.2 to 20.4 pg/mL; P = .13). Cold symptom scores correlated with bronchial immunostaining for FLAP (ρ = 0.93; P = .001). In normal subjects, rhinovirus colds induce bronchial inflammation with markedly enhanced expression of 5-LO pathway proteins and COX-2. |
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| AbstractList | Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these symptoms, bronchial biopsy specimens from 9 normal subjects (nonatopic and with no history of chronic lung disease) were immunostained for 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathway enzymes 2 weeks before and 4 days after experimental infection with human rhinovirus serotype 16. 5-LO-positive cell counts increased 9-fold (from 0.48 to 4.4 cells/mm(2); P <.05), and 5-LO-activating protein (FLAP)-positive cell counts increased 3.6-fold (from 1.8 to 6.5 cells/mm(2); P =.09). Levels of leukotriene A(4) hydrolase and leukotriene C(4) synthase were unchanged. COX-2--positive cell counts increased from 0 to 2.6 cells/mm(2) (P =.009), with no change in COX-1 levels. Increases of 3-4-fold were seen in levels of macrophages (P =.02) and mast cells (P =.07) but not of eosinophils (P >.4), and bronchoalveolar lavage fluid cysteinyl-leukotriene levels doubled (from 11.2 to 20.4 pg/mL; P =.13). Cold symptom scores correlated with bronchial immunostaining for FLAP (rho = 0.93; P =.001). In normal subjects, rhinovirus colds induce bronchial inflammation with markedly enhanced expression of 5-LO pathway proteins and COX-2. Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these symptoms, bronchial biopsy specimens from 9 normal subjects (nonatopic and with no history of chronic lung disease) were immunostained for 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathway enzymes 2 weeks before and 4 days after experimental infection with human rhinovirus serotype 16. 5-LO-positive cell counts increased 9-fold (from 0.48 to 4.4 cells/mm(2); P <.05), and 5-LO-activating protein (FLAP)-positive cell counts increased 3.6-fold (from 1.8 to 6.5 cells/mm(2); P =.09). Levels of leukotriene A(4) hydrolase and leukotriene C(4) synthase were unchanged. COX-2--positive cell counts increased from 0 to 2.6 cells/mm(2) (P =.009), with no change in COX-1 levels. Increases of 3-4-fold were seen in levels of macrophages (P =.02) and mast cells (P =.07) but not of eosinophils (P >.4), and bronchoalveolar lavage fluid cysteinyl-leukotriene levels doubled (from 11.2 to 20.4 pg/mL; P =.13). Cold symptom scores correlated with bronchial immunostaining for FLAP (rho = 0.93; P =.001). In normal subjects, rhinovirus colds induce bronchial inflammation with markedly enhanced expression of 5-LO pathway proteins and COX-2.Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these symptoms, bronchial biopsy specimens from 9 normal subjects (nonatopic and with no history of chronic lung disease) were immunostained for 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathway enzymes 2 weeks before and 4 days after experimental infection with human rhinovirus serotype 16. 5-LO-positive cell counts increased 9-fold (from 0.48 to 4.4 cells/mm(2); P <.05), and 5-LO-activating protein (FLAP)-positive cell counts increased 3.6-fold (from 1.8 to 6.5 cells/mm(2); P =.09). Levels of leukotriene A(4) hydrolase and leukotriene C(4) synthase were unchanged. COX-2--positive cell counts increased from 0 to 2.6 cells/mm(2) (P =.009), with no change in COX-1 levels. Increases of 3-4-fold were seen in levels of macrophages (P =.02) and mast cells (P =.07) but not of eosinophils (P >.4), and bronchoalveolar lavage fluid cysteinyl-leukotriene levels doubled (from 11.2 to 20.4 pg/mL; P =.13). Cold symptom scores correlated with bronchial immunostaining for FLAP (rho = 0.93; P =.001). In normal subjects, rhinovirus colds induce bronchial inflammation with markedly enhanced expression of 5-LO pathway proteins and COX-2. Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these symptoms, bronchial biopsy specimens from 9 normal subjects (nonatopic and with no history of chronic lung disease) were immunostained for 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathway enzymes 2 weeks before and 4 days after experimental infection with human rhinovirus serotype 16. 5-LO-positive cell counts increased 9-fold (from 0.48 to 4.4 cells/mm super(2); P < .05), and 5-LO-activating protein (FLAP)-positive cell counts increased 3.6-fold (from 1.8 to 6.5 cells/mm super(2); P = .09). Levels of leukotriene A sub(4) hydrolase and leukotriene C sub(4) synthase were unchanged. COX-2-positive cell counts increased from 0 to 2.6 cells/mm super(2) (P = .009), with no change in COX-1 levels. Increases of 3-4-fold were seen in levels of macrophages (P = .02) and mast cells (P = .07) but not of eosinophils (P > .4), and bronchoalveolar lavage fluid cysteinyl-leukotriene levels doubled (from 11.2 to 20.4 pg/mL; P = .13). Cold symptom scores correlated with bronchial immunostaining for FLAP ( rho = 0.93, P = .001). In normal subjects, rhinovirus colds induce bronchial inflammation with markedly enhanced expression of 5-LO pathway proteins and COX-2. Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these symptoms, bronchial biopsy specimens from 9 normal subjects (nonatopic and with no history of chronic lung disease) were immunostained for 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathway enzymes 2 weeks before and 4 days after experimental infection with human rhinovirus serotype 16.5-LO-positive cell counts increased 9-fold (from 0.48 to 4.4 cells/mm2; P <.05), and 5- LO-activating protein (FLAP)-positive cell counts increased 3.6-fold (from 1.8 to 6.5 cells/ mm2; P = .09). Levels of leukotriene A4 hydrolase and leukotriene C4 synthase were unchanged. COX-2-positive cell counts increased from 0 to 2.6 cells/mm2 (P = .009), with no change in COX-1 levels. Increases of 3-4-fold were seen in levels of macrophages (P = .02) and mast cells (P = .07) but not of eosinophils (P > .4), and bronchoalveolar lavage fluid cysteinyl-leukotriene levels doubled (from 11.2 to 20.4 pg/mL; P = .13). Cold symptom scores correlated with bronchial immunostaining for FLAP (ρ = 0.93; P = .001). In normal subjects, rhinovirus colds induce bronchial inflammation with markedly enhanced expression of 5-LO pathway proteins and COX-2. Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these symptoms, bronchial biopsy specimens from 9 normal subjects (nonatopic and with no history of chronic lung disease) were immunostained for 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathway enzymes 2 weeks before and 4 days after experimental infection with human rhinovirus serotype 16. 5-LO-positive cell counts increased 9-fold (from 0.48 to 4.4 cells/mm²; P <.05), and 5-LO-activating protein (FLAP)-positive cell counts increased 3.6-fold (from 1.8 to 6.5 cells/mm²; P = .09). Levels of leukotriene AȈ hydrolase and leukotriene C₄ synthase were unchanged. COX-2-positive cell counts increased from 0 to 2.6 cells/mm² (P = .009), with no change in COX-1 levels. Increases of 3-4-fold were seen in levels of macrophages (P = .02) and mast cells (P = .07) but not of eosinophils (P >.4), and bronchoalveolar lavage fluid cysteinyl-leukotriene levels doubled (from 11.2 to 20.4 pg/mL; P = .13). Cold symptom scores correlated with bronchial immunostaining for FLAP (p = 0.93; P = .001). In normal subjects, rhinovirus colds induce bronchial inflammation with markedly enhanced expression of 5-LO pathway proteins and COX-2. |
| Author | Bardin, Philip G. Fraenkel, David J. Sanderson, Gwendolyn Penrose, John F. Sampson, Anthony P. Johnston, Sebastian L. Gilby, Natalie Holgate, Stephen T. Seymour, Michelle L. |
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| Keywords | Human Prostaglandin-endoperoxide synthase Respiratory disease Enzyme Picornaviridae Pathogenesis Infection Virus Experimental disease Viral disease Oxidoreductases Lipoxygenase Macrophage Rhinovirus |
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| Notes | istex:5C356DE9E37576502AE3E13BE2AA09A99B3A854F Present affiliations: Mucosal Inflammation Research Group, University of Calgary, Alberta, Canada (M.L.S.); Monash Medical Centre, Clayton, Victoria (P.G.B.), and Department of Intensive Care, Royal Brisbane Hospital, Herston, Queensland, Australia (D.J.F.). ark:/67375/HXZ-8K0174JM-H ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
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| PublicationTitle | The Journal of infectious diseases |
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| References | 12195364 - J Infect Dis. 2002 Sep 1;186(5):723; author reply 723-4 |
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| Snippet | Rhinovirus infections cause wheeze, cough, and bronchial hyperresponsiveness. To investigate the involvement of cysteinyl-leukotrienes and prostanoids in these... |
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| SubjectTerms | 5-Lipoxygenase Arachidonate 5-Lipoxygenase - analysis Arachidonate 5-Lipoxygenase - biosynthesis Biological and medical sciences Biopsies Biopsy Bronchi - enzymology Bronchi - pathology Common Cold - drug therapy Common Cold - enzymology Concise Communications Cyclooxygenase 2 Cysteine - analysis cysteinyl-leukotrienes Enzymes Eosinophils Experimental viral diseases and models Humans Infections Infectious diseases Isoenzymes - analysis Isoenzymes - biosynthesis Leukocytes Leukotrienes - analysis Macrophages Mast cells Medical sciences Membrane Proteins Monocytes Prostaglandin-Endoperoxide Synthases - analysis Prostaglandin-Endoperoxide Synthases - biosynthesis prostanoids Rhinovirus Viral diseases Viruses |
| Title | Rhinovirus Infection Increases 5-Lipoxygenase and Cyclooxygenase-2 in Bronchial Biopsy Specimens from Nonatopic Subjects |
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