The Spatiotemporal Coupling: Regional Energy Failure and Aberrant Proteins in Neurodegenerative Diseases

• Published in: International journal of molecular sciences Vol. 22; no. 21; p. 11304
• Main Authors: Virtuoso, Assunta, Colangelo, Anna Maria, Maggio, Nicola, Fennig, Uri, Weinberg, Nitai, Papa, Michele, De Luca, Ciro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.10.2021; MDPI
• Subjects: Alzheimer's disease; Animals; Astrocytes - metabolism; Biomarkers; Brain; Central nervous system; Central Nervous System - metabolism; Central Nervous System - physiopathology; Energy consumption; extra-cellular matrix; Extracellular matrix; Functional anatomy; Gene expression; Heparan sulfate; Humans; Immune system; Metabolism; Microglia - metabolism; Neurodegeneration; neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - physiopathology; Neuroglia - metabolism; Neurological diseases; Neuronal Plasticity - physiology; Neurons - metabolism; neurovascular unit; Parkinson's disease; Pathology; Phenotypes; Phosphorylation; Proteins; Review; Spatio-Temporal Analysis; Synapses - metabolism; Synaptic cleft; Synaptic plasticity; systems biology; systems biology; neurodegenerative diseases; extra-cellular matrix; metabolism; astrocytes; synaptic plasticity; microglia; neurons; neurovascular unit; oligodendroglia

The spatial and temporal coordination of each element is a pivotal characteristic of systems, and the central nervous system (CNS) is not an exception. Glial elements and the vascular interface have been considered more recently, together with the extracellular matrix and the immune system. However,...