Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway

• Published in: International journal of molecular sciences Vol. 23; no. 23; p. 14935
• Main Authors: Cai, Shaoyi, Chen, Zhiyou, Tang, Heng, Meng, Siyan, Tao, Liang, Wang, Qin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.11.2022; MDPI
• Subjects: Apoptosis; Bioinformatics; Brain cancer; Brain Neoplasms - metabolism; Brain tumors; bulk RNA-seq; Cancer therapies; Cell cycle; Cell death; Cell growth; Cell Proliferation - genetics; Chemotherapy; Cholecystokinin; Computational Biology; FKBP1A; Flow cytometry; GBM; Gene expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioblastoma - metabolism; Humans; Kinases; Medical prognosis; Network analysis; pathway enrichment; Proteins; scRNA-seq; Signal transduction; Tacrolimus Binding Proteins - genetics; Tacrolimus Binding Proteins - metabolism; Therapeutic targets; TOR protein; Tumors; WGCNA; FKBP1A; pathway enrichment; scRNA-seq; GBM; bulk RNA-seq; WGCNA

Glioblastoma (GBM), the most deadly primary brain tumor, presents a major medical difficulty. The need for better therapeutic targets in GBM is therefore urgent. A growing body of evidence suggests that the gene plays an important role in tumor progression and may be therapeutically useful. However,...