Downregulation of tumor suppressor RACK1 by Helicobacter pylori infection promotes gastric carcinogenesis through the integrin β-1/NF-κB signaling pathway

• Published in: Cancer letters Vol. 450; pp. 144 - 154
• Main Authors: Hu, Yi, Liu, Jian-Ping, Li, Xue-Yang, Cai, Yan, He, Cong, Li, Nian-Shuang, Xie, Chuan, Xiong, Zhi-Juan, Ge, Zhong-Ming, Lu, Nong-Hua, Zhu, Yin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 28.05.2019; Elsevier Limited
• Subjects: Animals; Antigens, Bacterial - metabolism; Bacterial Proteins - metabolism; Cancer; Carcinogenesis; Cell cycle; Cell Line, Tumor; Cytokines; Disease control; Disease prevention; Down-Regulation; Gastric cancer; Gerbillinae; Helicobacter Infections - metabolism; Helicobacter pylori; Helicobacter pylori - metabolism; Humans; Infections; Inflammation; Integrin beta1 - metabolism; Integrin β-1; Kinases; Male; Medical research; Molecular modelling; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; NF-kappa B - metabolism; NF-κB; NF-κB protein; Pathogens; Prognosis; Protein kinase C; Proteins; RACK1; Receptors for Activated C Kinase - genetics; Receptors for Activated C Kinase - metabolism; Signal Transduction; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - microbiology; Tumor suppressor genes; Beijing China; United States > US; China; RACK1; NF-κB; Helicobacter pylori; Gastric cancer; Integrin β-1

Receptor of activated protein kinase C 1 (RACK1) is downregulated in gastric cancer and is involved in modulating NF-κB signaling pathway activity. However, the underlying molecular mechanisms regulating RACK1 expression are unclear. In this study, we demonstrated that downregulated expression of RA...