LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole

• Published in: The Journal of cell biology Vol. 221; no. 1
• Main Authors: Shen, Xiao-Lin, Yuan, Jin-Feng, Qin, Xuan-He, Song, Guang-Ping, Hu, Huai-Bin, Tu, Hai-Qing, Song, Zeng-Qing, Li, Pei-Yao, Xu, Yu-Ling, Li, Sen, Jian, Xiao-Xiao, Li, Jia-Ning, He, Chun-Yu, Yu, Xi-Ping, Liang, Li-Yun, Wu, Min, Han, Qiu-Ying, Wang, Kai, Li, Ai-Ling, Zhou, Tao, Zhang, Yu-Cheng, Wang, Na, Li, Hui-Yan
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 03.01.2022
• Subjects: Animals; Cell Cycle Proteins - metabolism; Cell Line; Centrioles - metabolism; Chains; Cilia; Cilia - metabolism; Development; Embryogenesis; Embryonic growth stage; Humans; Mice; Microtubule-Associated Proteins - metabolism; mRNA; Multiprotein Complexes; Organogenesis; Phosphoproteins - metabolism; RNA-Binding Proteins - metabolism; Splicing; Splicing factors; Substrate Specificity; Ubiquitin; Ubiquitin - metabolism; Ubiquitin-protein ligase; Ubiquitination; Zebrafish

Primary cilia transduce diverse signals in embryonic development and adult tissues. Defective ciliogenesis results in a series of human disorders collectively known as ciliopathies. The CP110–CEP97 complex removal from the mother centriole is an early critical step for ciliogenesis, but the underlyi...