High-dose chemotherapy and APSCT as a potential cure for relapsing hemolysing AILD

• Published in: Leukemia research Vol. 25; no. 3; pp. 267 - 270
• Main Authors: Lindahl, Jenny, Kimby, Eva, Björkstrand, Bo, Christensson, Birger, Hellström-Lindberg, Eva
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.03.2001; Elsevier Science
• Subjects: Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD); Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Autologous peripheral stemcell transplantation (APSCT); Biological and medical sciences; CD34+ cells; Combined treatments (chemotherapy of immunotherapy associated with an other treatment); Cyclophosphamide - administration & dosage; Doxorubicin - administration & dosage; Guillain-Barre Syndrome - etiology; Hematopoietic Stem Cell Transplantation; Hemolysis; Humans; Immunoblastic Lymphadenopathy - complications; Immunoblastic Lymphadenopathy - therapy; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Prednisolone - administration & dosage; Remission Induction - methods; Transplantation, Autologous; Vincristine - administration & dosage; Hemolysis; BEAM, BCNU, melfalan, etoposide and cytarabine; AITL, angioimmunoblastic T-cell lymphoma; FACS, flow cytometric analysis; Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD); BMT, bone marrow transplantation; CR, complete remission; AILD, angioimmunoblastic lymphadenopathy with dysproteinemia; APSCT, autologous peripheral stemcell transplantation; Autologous peripheral stemcell transplantation (APSCT); CHOP chemotherapy, cyclophosphamide, doxorubicine, vincristine and prednisone; DHAP, cisplatine, cytarabine and cortisone; CT-scan, computed tomography; CD34+ cells; Antineoplastic agent; Stem cell; Hematopoietic cell; Male; Doxorubicin; Blood; Alkaloid; Autograft; Lymphoproliferative syndrome; T-Lymphocyte; Adult; Graft; Antimitotic; High dose; Human; Corticosteroid; Drug combination; Malignant hemopathy; Prednisone; Recurrent; Non Hodgkin lymphoma; Vincristine; Case study; Alkylating agent; Chemotherapy; Cyclophosphamide; Oxazaphosphinane derivatives; Nitrogen mustard; Immunoblastic lymphadenopathy; Anthracyclins; Combined treatment; Therapeutic protocol
• DOI: 10.1016/S0145-2126(00)00134-X
• ISSN: 0145-2126

Angioimmunoblastic lymphadenopathy with dysproteinemia (or dysgammaglobulinemia) (AILD) is a lymphoproliferative disorder with cytogenetic and molecular abnormalities characteristic of malignant T-cell lymphoma (angioimmunoblastic T-cell lymphoma — AITL). We report the clinical course of a 58-year-old male patient with unusually aggressive AILD, including severe hemolysis and Guillain–Barré syndrome, who entered complete remission after CHOP therapy, but had a full relapse after 2 months. At relapse, treatment with high-dose chemotherapy followed by autologous peripheral stem cell transplantation (APSCT) with CD34 selected cells was shown to be successful. The patient is alive and disease-free 3 years after diagnosis and 32 months after APSCT. Considering the poor prognosis of the majority of patients with AILD, intensive treatment followed by APSCT, may be a subject for further studies.