Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

• Published in: The Journal of experimental medicine Vol. 208; no. 11; pp. 2237 - 2249
• Main Authors: Liao, Hua-Xin, Chen, Xi, Munshaw, Supriya, Zhang, Ruijun, Marshall, Dawn J., Vandergrift, Nathan, Whitesides, John F., Lu, Xiaozhi, Yu, Jae-Sung, Hwang, Kwan-Ki, Gao, Feng, Markowitz, Martin, Heath, Sonya L., Bar, Katharine J., Goepfert, Paul A., Montefiori, David C., Shaw, George C., Alam, S. Munir, Margolis, David M., Denny, Thomas N., Boyd, Scott D., Marshal, Eleanor, Egholm, Michael, Simen, Birgitte B., Hanczaruk, Bozena, Fire, Andrew Z., Voss, Gerald, Kelsoe, Garnett, Tomaras, Georgia D., Moody, M. Anthony, Kepler, Thomas B., Haynes, Barton F.
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 24.10.2011
• Subjects: Adult; Cell Lineage; Female; HIV Antibodies - classification; HIV Antibodies - genetics; HIV Antibodies - immunology; HIV Envelope Protein gp41 - immunology; HIV-1 - immunology; Human immunodeficiency virus 1; Humans; Male; Mutation; Phylogeny; Plasma Cells - immunology; Plasma Cells - virology; Sequence Analysis, DNA; Viral Load; Viremia - immunology

The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission, we isolated and studied gp41-reactive plasma c...