Mechanism of low molecular weight GTP binding protein RAC1 in injury of neural function of rats with cerebral ischemia reperfusion
Objective: To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion. Methods: Middle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h...
Saved in:
| Published in | Asian Pacific journal of tropical medicine Vol. 9; no. 5; pp. 460 - 464 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Elsevier B.V
01.05.2016
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Objective: To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion. Methods: Middle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h, the rat model of cerebral ischemia reperfusion injury was built, while the middle cerebral artery was ligated. The rats were randomly divided into the sham group, cerebral ischemia reperfusion group(I/R group) and the group with the injection of RAC1 activity inhibitor NSC23766(NSC group). The survival and neurological severity score of rats in each group were observed and recorded. Nissl staining was employed to observe the nerve cells, and Western blot to detect expression of RAC1, superoxide dismutase and malondialdehyde. Results: Number of nerve cells for rats in NSC group was significantly more than that in I/R group, but significantly less than that in sham group, with the statistical difference(P<0.05). The brain water content for rats in NSC group was significantly lower than that in I/R group, but significantly higher than that in sham group, with the statistical difference(P<0.05). The expression of RAC1 and malondialdehyde for rats in NSC group was significantly lower than that in I/R group, but higher than that in sham group; while the expression of superoxide dismutase was lower than that in sham group, but higher than that in I/R group, with the statistical difference(P<0.05). Conclusions: The inhibition of RAC1 activity can reduce the oxidative stress, reduce the neurologic impairment because of cerebral ischemia reperfusion and thus protect the neural function. |
|---|---|
| AbstractList | To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion.
Middle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h, the rat model of cerebral ischemia reperfusion injury was built, while the middle cerebral artery was ligated. The rats were randomly divided into the sham group, cerebral ischemia reperfusion group (I/R group) and the group with the injection of RAC1 activity inhibitor NSC23766 (NSC group). The survival and neurological severity score of rats in each group were observed and recorded. Nissl staining was employed to observe the nerve cells, and Western blot to detect expression of RAC1, superoxide dismutase and malondialdehyde.
Number of nerve cells for rats in NSC group was significantly more than that in I/R group, but significantly less than that in sham group, with the statistical difference (P < 0.05). The brain water content for rats in NSC group was significantly lower than that in I/R group, but significantly higher than that in sham group, with the statistical difference (P < 0.05). The expression of RAC1 and malondialdehyde for rats in NSC group was significantly lower than that in I/R group, but higher than that in sham group; while the expression of superoxide dismutase was lower than that in sham group, but higher than that in I/R group, with the statistical difference (P < 0.05).
The inhibition of RAC1 activity can reduce the oxidative stress, reduce the neurologic impairment because of cerebral ischemia reperfusion and thus protect the neural function. Objective: To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion. Methods: Middle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h, the rat model of cerebral ischemia reperfusion injury was built, while the middle cerebral artery was ligated. The rats were randomly divided into the sham group, cerebral ischemia reperfusion group (I/R group) and the group with the injection of RAC1 activity inhibitor NSC23766 (NSC group). The survival and neurological severity score of rats in each group were observed and recorded. Nissl staining was employed to observe the nerve cells, and Western blot to detect expression of RAC1, superoxide dismutase and malondialdehyde. Results: Number of nerve cells for rats in NSC group was significantly more than that in I/R group, but significantly less than that in sham group, with the statistical difference (P < 0.05). The brain water content for rats in NSC group was significantly lower than that in I/R group, but significantly higher than that in sham group, with the statistical difference (P < 0.05). The expression of RAC1 and malondialdehyde for rats in NSC group was significantly lower than that in I/R group, but higher than that in sham group; while the expression of superoxide dismutase was lower than that in sham group, but higher than that in I/R group, with the statistical difference (P < 0.05). Conclusions: The inhibition of RAC1 activity can reduce the oxidative stress, reduce the neurologic impairment because of cerebral ischemia reperfusion and thus protect the neural function. To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion.OBJECTIVETo discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion.Middle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h, the rat model of cerebral ischemia reperfusion injury was built, while the middle cerebral artery was ligated. The rats were randomly divided into the sham group, cerebral ischemia reperfusion group (I/R group) and the group with the injection of RAC1 activity inhibitor NSC23766 (NSC group). The survival and neurological severity score of rats in each group were observed and recorded. Nissl staining was employed to observe the nerve cells, and Western blot to detect expression of RAC1, superoxide dismutase and malondialdehyde.METHODSMiddle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h, the rat model of cerebral ischemia reperfusion injury was built, while the middle cerebral artery was ligated. The rats were randomly divided into the sham group, cerebral ischemia reperfusion group (I/R group) and the group with the injection of RAC1 activity inhibitor NSC23766 (NSC group). The survival and neurological severity score of rats in each group were observed and recorded. Nissl staining was employed to observe the nerve cells, and Western blot to detect expression of RAC1, superoxide dismutase and malondialdehyde.Number of nerve cells for rats in NSC group was significantly more than that in I/R group, but significantly less than that in sham group, with the statistical difference (P < 0.05). The brain water content for rats in NSC group was significantly lower than that in I/R group, but significantly higher than that in sham group, with the statistical difference (P < 0.05). The expression of RAC1 and malondialdehyde for rats in NSC group was significantly lower than that in I/R group, but higher than that in sham group; while the expression of superoxide dismutase was lower than that in sham group, but higher than that in I/R group, with the statistical difference (P < 0.05).RESULTSNumber of nerve cells for rats in NSC group was significantly more than that in I/R group, but significantly less than that in sham group, with the statistical difference (P < 0.05). The brain water content for rats in NSC group was significantly lower than that in I/R group, but significantly higher than that in sham group, with the statistical difference (P < 0.05). The expression of RAC1 and malondialdehyde for rats in NSC group was significantly lower than that in I/R group, but higher than that in sham group; while the expression of superoxide dismutase was lower than that in sham group, but higher than that in I/R group, with the statistical difference (P < 0.05).The inhibition of RAC1 activity can reduce the oxidative stress, reduce the neurologic impairment because of cerebral ischemia reperfusion and thus protect the neural function.CONCLUSIONSThe inhibition of RAC1 activity can reduce the oxidative stress, reduce the neurologic impairment because of cerebral ischemia reperfusion and thus protect the neural function. Objective: To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia reperfusion. Methods: Middle cerebral artery of rats was ligated and the ligature was released to restore the perfusion after 2 h, the rat model of cerebral ischemia reperfusion injury was built, while the middle cerebral artery was ligated. The rats were randomly divided into the sham group, cerebral ischemia reperfusion group(I/R group) and the group with the injection of RAC1 activity inhibitor NSC23766(NSC group). The survival and neurological severity score of rats in each group were observed and recorded. Nissl staining was employed to observe the nerve cells, and Western blot to detect expression of RAC1, superoxide dismutase and malondialdehyde. Results: Number of nerve cells for rats in NSC group was significantly more than that in I/R group, but significantly less than that in sham group, with the statistical difference(P<0.05). The brain water content for rats in NSC group was significantly lower than that in I/R group, but significantly higher than that in sham group, with the statistical difference(P<0.05). The expression of RAC1 and malondialdehyde for rats in NSC group was significantly lower than that in I/R group, but higher than that in sham group; while the expression of superoxide dismutase was lower than that in sham group, but higher than that in I/R group, with the statistical difference(P<0.05). Conclusions: The inhibition of RAC1 activity can reduce the oxidative stress, reduce the neurologic impairment because of cerebral ischemia reperfusion and thus protect the neural function. |
| Author | Ya-Hong Li Lu-Jun Qiao Xiao-Ying Lin |
| AuthorAffiliation | Department of Critical Care Medicine, Dongying Shengli Oil Field Central Hospital;Department of Neurology, Affiliated Ji’nan Central Hospital of School of Medicine, Shandong University |
| Author_xml | – sequence: 1 givenname: Ya-Hong surname: Li fullname: Li, Ya-Hong organization: Department of Critical Care Medicine, Dongying Shengli Oil Field Central Hospital, Dongying, Shandong 257034, China – sequence: 2 givenname: Lu-Jun surname: Qiao fullname: Qiao, Lu-Jun email: dyqiaolujun@126.com organization: Department of Critical Care Medicine, Dongying Shengli Oil Field Central Hospital, Dongying, Shandong 257034, China – sequence: 3 givenname: Xiao-Ying surname: Lin fullname: Lin, Xiao-Ying organization: Department of Neurology, Affiliated Ji'nan Central Hospital of School of Medicine, Shandong University, Ji'nan, Shandong 250000, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27261857$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkU1v1DAQhi1URLelvwAJ-chlg7-StQ8cqhW0SEUgVM6W44x3vUqcre101Su_HKfbcuCA6st47Oedsec9QydhDIDQO0oqSmjzcVeZ_S4PFStJRXhFmHiFFozXbCmoaE7QgipVL1eNqE_RRUo7UhZnSq34G3TKVqyhsl4t0O9vYLcm-DTg0eF-POBh7MFOvYn4AH6zzfjq9gdufeh82OB9HDP4gH9eriku0YfdFB9maYApmh67KdjsxzAfRZMTPvi8xRYitPO1T3YLgzc4wh6im1JB36LXzvQJLp7iOfr15fPt-np58_3q6_ryZmmFpHkpjWANoWBo08qukVSwjhtiWmG54sYQ5RxvXSsdFUbZQlInqBGOE1GD4vwcfTjWLZ-4myBlPZTnQN-bAOOUNJVENrSh_AXoSgnKWF2Lgr5_Qqd2gE7vox9MfNDPIy6AOgI2jilFcNr6bOYZ5Wh8rynRs6N6px8d1bOjmnBdHC1a_o_2ufz_VZ-OKijTvPcQdbIegoXOR7BZd6N_YdftGDZ3xfe_baWSQjKpaiKkULUQsuaPO8L_AFJjyq8 |
| CitedBy_id | crossref_primary_10_3389_fcvm_2022_813983 crossref_primary_10_1111_bpa_12562 |
| Cites_doi | 10.1155/2015/504061 10.1186/s12871-015-0147-0 10.3389/fnmol.2015.00065 10.1007/s10396-014-0591-3 10.1016/j.brainresbull.2015.11.007 10.3748/wjg.v21.i42.12114 10.1016/j.apsb.2014.11.002 |
| ContentType | Journal Article |
| Copyright | 2016 Hainan Medical College Copyright © 2016 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2016 Hainan Medical College – notice: Copyright © 2016 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved. |
| DBID | 2RA 92L CQIGP ~WA 6I. AAFTH AAYXX CITATION NPM 7X8 7T2 C1K F1W H95 H97 L.G |
| DOI | 10.1016/j.apjtm.2016.03.024 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库- 镜像站点 ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic Health and Safety Science Abstracts (Full archive) Environmental Sciences and Pollution Management ASFA: Aquatic Sciences and Fisheries Abstracts Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality Aquatic Science & Fisheries Abstracts (ASFA) Professional |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic Aquatic Science & Fisheries Abstracts (ASFA) Professional Health & Safety Science Abstracts Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality ASFA: Aquatic Sciences and Fisheries Abstracts Environmental Sciences and Pollution Management |
| DatabaseTitleList | PubMed Aquatic Science & Fisheries Abstracts (ASFA) Professional MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Mechanism of low molecular weight GTP binding protein RAC1 in injury of neural function of rats with cerebral ischemia reperfusion |
| EISSN | 2352-4146 |
| EndPage | 464 |
| ExternalDocumentID | 27261857 10_1016_j_apjtm_2016_03_024 S1995764516300244 89848289504849544853484950 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Natural Science Foundation of Shandong Province grantid: ZR2009CL018 |
| GroupedDBID | --- --K -05 -0E -SE -S~ .~1 0R~ 0SF 188 1B1 1~. 1~5 2B. 2C~ 2RA 4.4 457 4G. 53G 5VR 5VS 6I. 7-5 71M 92F 92I 92L 92M 93N 93R 9D9 9DE AACTN AAEDW AAFTH AAIKJ AALRI AAQFI AAXUO ABBQC ABJNI ABKZE ABMAC ACGFS ADEZE AEKER AENEX AEXQZ AFUIB AGHFR AGYEJ AITUG AJRQY ALMA_UNASSIGNED_HOLDINGS AMRAJ CAJEE CAJUS CCEZO CHBEP CIEJG CQIGP DYU EBS ECGQY EJD EP3 FA0 FDB FEDTE FNPLU GBLVA GROUPED_DOAJ HVGLF HZ~ J1W JUIAU KQ8 M41 MO0 M~E N9A NCXOZ O-L O9- OK1 OVD OZF P-8 P-9 PC. Q-- Q-4 Q38 R-E RIG RMW ROL RT5 S.. SDF SES SSZ T8U TCJ TEORI TGQ U1F U1G U5E U5O UZ5 W3E WFFXF ~MZ ~WA AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADJBI ADNMO ADVLN AEUPX AFPUW AIGII AKBMS AKRWK AKYEP CITATION H13 NPM 7X8 7T2 C1K F1W H95 H97 L.G |
| ID | FETCH-LOGICAL-c481t-8a42601ea16b8d68142d3a0ab4c393aa09ff3bfb8f14a9c01e1f41a4f3045e933 |
| IEDL.DBID | .~1 |
| ISSN | 1995-7645 2352-4146 |
| IngestDate | Thu Jul 10 17:29:51 EDT 2025 Fri Jul 11 11:49:25 EDT 2025 Fri Jan 03 00:55:36 EST 2025 Thu Apr 24 22:57:10 EDT 2025 Tue Jul 01 03:00:04 EDT 2025 Fri Feb 23 02:13:02 EST 2024 Wed Feb 14 10:14:46 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Neural function Cerebral ischemia reperfusion RAC1 |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 http://www.elsevier.com/tdm/userlicense/1.0 Copyright © 2016 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c481t-8a42601ea16b8d68142d3a0ab4c393aa09ff3bfb8f14a9c01e1f41a4f3045e933 |
| Notes | Ya-Hong Li;Lu-Jun Qiao;Xiao-Ying Lin;Department of Critical Care Medicine, Dongying Shengli Oil Field Central Hospital;Department of Neurology, Affiliated Ji’nan Central Hospital of School of Medicine, Shandong University ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S1995764516300244 |
| PMID | 27261857 |
| PQID | 1794122554 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_1808616133 proquest_miscellaneous_1794122554 pubmed_primary_27261857 crossref_citationtrail_10_1016_j_apjtm_2016_03_024 crossref_primary_10_1016_j_apjtm_2016_03_024 elsevier_sciencedirect_doi_10_1016_j_apjtm_2016_03_024 chongqing_primary_89848289504849544853484950 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-05-01 |
| PublicationDateYYYYMMDD | 2016-05-01 |
| PublicationDate_xml | – month: 05 year: 2016 text: 2016-05-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | India |
| PublicationPlace_xml | – name: India |
| PublicationTitle | Asian Pacific journal of tropical medicine |
| PublicationTitleAlternate | Asian Pacific Journal of Tropical Medicine |
| PublicationYear | 2016 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Lu, Cai, Tan, Deng, Yi, Liu (bib12) 2014; 34 Gao, Yao, Wang, Yang, Liu, Tao (bib8) 2015; 8 Hong, Zeng, Wang, Wang, Li (bib9) 2008; 7 Palladini, Ferrigno, Richelmi, Perlini, Vairetti (bib15) 2015; 21 Li, Zheng, Li, Li, Zhao, Wang (bib18) 2012; 16 Liao, Guo, Li, Rao (bib20) 2014; 11 Huang, Deng, Qiu, Wang, Tang, Zeng (bib5) 2013; 29 Jiao, Tong, Dong, Gu, Yu, Yu (bib7) 2014; 8 Pennucci, Talpo, Astro, Montinaro, Morè, Cursi (bib11) 2016; 26 Cai, Liu, Wang, Wang, Tan (bib13) 2009; 23 Kmet, Tkachuk (bib16) 2015; 59 Sun, Liu, Han, Xu, Zhang, Wang (bib21) 2015; 8 Sun, Fan, Han (bib2) 2015; 5 Xu, Wang, Song, Wei, He, Peng (bib17) 2015; 120 Zhang, Ma, Xu, Huang (bib3) 2015; 15 Chen, Li, Tan (bib6) 2014; 49 Wang, Wan (bib19) 2015; 26 Li, Fan, Liu, Wang, Wang, Xie (bib14) 2013; 52 Kao, Chung, Chang, Lin, Sheu, Huang (bib1) 2015; 2015 Xue, Guo, Huang, Zhang, Chen, Liang (bib4) 2015; 42 Tan, Chen, Liang, Li, Wang, Meng (bib10) 2014; 31 Tan (10.1016/j.apjtm.2016.03.024_bib10) 2014; 31 Li (10.1016/j.apjtm.2016.03.024_bib18) 2012; 16 Pennucci (10.1016/j.apjtm.2016.03.024_bib11) 2016; 26 Wang (10.1016/j.apjtm.2016.03.024_bib19) 2015; 26 Palladini (10.1016/j.apjtm.2016.03.024_bib15) 2015; 21 Hong (10.1016/j.apjtm.2016.03.024_bib9) 2008; 7 Gao (10.1016/j.apjtm.2016.03.024_bib8) 2015; 8 Xu (10.1016/j.apjtm.2016.03.024_bib17) 2015; 120 Huang (10.1016/j.apjtm.2016.03.024_bib5) 2013; 29 Chen (10.1016/j.apjtm.2016.03.024_bib6) 2014; 49 Lu (10.1016/j.apjtm.2016.03.024_bib12) 2014; 34 Sun (10.1016/j.apjtm.2016.03.024_bib21) 2015; 8 Kao (10.1016/j.apjtm.2016.03.024_bib1) 2015; 2015 Sun (10.1016/j.apjtm.2016.03.024_bib2) 2015; 5 Zhang (10.1016/j.apjtm.2016.03.024_bib3) 2015; 15 Li (10.1016/j.apjtm.2016.03.024_bib14) 2013; 52 Xue (10.1016/j.apjtm.2016.03.024_bib4) 2015; 42 Liao (10.1016/j.apjtm.2016.03.024_bib20) 2014; 11 Cai (10.1016/j.apjtm.2016.03.024_bib13) 2009; 23 Kmet (10.1016/j.apjtm.2016.03.024_bib16) 2015; 59 Jiao (10.1016/j.apjtm.2016.03.024_bib7) 2014; 8 |
| References_xml | – volume: 26 start-page: 34 year: 2015 end-page: 38 ident: bib19 article-title: The expression and function of NADPH oxidase in common cardiovascular diseases publication-title: China Med Her – volume: 8 start-page: 12970 year: 2015 end-page: 12976 ident: bib21 article-title: The role of great auricular-facial nerve neurorrhaphy in facial nerve damage publication-title: Int J Clin Exp Med – volume: 49 start-page: 645 year: 2014 end-page: 648 ident: bib6 article-title: Effect of adenosine preconditioning on endogenous neural stem cell proliferation in rats after focal cerebral ischemia-reperfusion injury publication-title: J Zhengzhou Univ Med Sci – volume: 26 start-page: 873 year: 2016 end-page: 890 ident: bib11 article-title: Loss of either Rac1 or Rac3 GTPase differentially affects the behavior of mutant mice and the development of functional GABAergic networks publication-title: Cereb Cortex – volume: 21 start-page: 12114 year: 2015 end-page: 12124 ident: bib15 article-title: Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: a review publication-title: World J Gastroenterol – volume: 2015 start-page: 504061 year: 2015 ident: bib1 article-title: Salutary effects of cepharanthine against skeletal muscle and kidney injuries following limb ischemia/reperfusion publication-title: Evid Based Complement Alternat Med – volume: 15 start-page: 165 year: 2015 ident: bib3 article-title: Pretreatment of parecoxib attenuates hepatic ischemia/reperfusion injury in rats publication-title: BMC Anesthesiol – volume: 8 start-page: 65 year: 2015 ident: bib8 article-title: Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory publication-title: Front Mol Neurosci – volume: 5 start-page: 8 year: 2015 end-page: 24 ident: bib2 article-title: Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage publication-title: Acta Pharm Sin B – volume: 120 start-page: 97 year: 2015 end-page: 105 ident: bib17 article-title: Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats publication-title: Brain Res Bull – volume: 31 start-page: 66 year: 2014 end-page: 71 ident: bib10 article-title: Effect of electroacupuncture on Rac-1 mRNA expression in cerebral cortex and cervical spinal cord of rats with hypertension-induced cerebral infarction publication-title: J Guangzhou Univ Tradit Chin Med – volume: 7 start-page: 1345 year: 2008 end-page: 1350 ident: bib9 article-title: Inhibitive action of atorvastatin on NADPH oxidase-derived superoxide anion in ischemic brain tissue after reperfusion in rats publication-title: Chin J Pathophysiol – volume: 42 start-page: 207 year: 2015 end-page: 214 ident: bib4 article-title: Effects of gradual low-flow reperfusion postconditioning on ischemia-reperfusion injury involving incomplete testicular torsion in rabbits publication-title: J Med Ultrason – volume: 23 start-page: 64 year: 2009 end-page: 66 ident: bib13 article-title: Influence of electroacupuncture at Quchi and Zusanli on neurologic deficit impairment in rats with cerebral ischemia-reperfusion injury publication-title: Acta Univ Tradit Med Sin Pharmacol Shanghai – volume: 52 start-page: 188 year: 2013 end-page: 191 ident: bib14 article-title: An evaluation of the impact of cerebrovascular disease deaths on life expectancy in China publication-title: Chin J Intern Med – volume: 11 start-page: 1573 year: 2014 end-page: 1583 ident: bib20 article-title: The review on the cell signal transduction pathway related to free radicals publication-title: Chin J Cell Biol – volume: 34 start-page: 6 year: 2014 end-page: 9 ident: bib12 article-title: Experience and improvement of preparation of the cerebral ischemia model by string-fastenings method for middle cerebral artery occlusion publication-title: J Hunan Univ Chin Med – volume: 16 start-page: 2033 year: 2012 end-page: 2038 ident: bib18 article-title: Effects of oxidative stress and Rac1/2 on venous wall and their roles in traumatic deep vein thrombosis publication-title: Chin J Tissue Eng Res – volume: 8 start-page: 841 year: 2014 end-page: 845 ident: bib7 article-title: Effect of gap junction in ischemic post-conditioning on cerebral ischemic-reperfusion injury in rats and its associated mechanism publication-title: Chin J Clin Pharmacol Ther – volume: 59 start-page: 19 year: 2015 end-page: 22 ident: bib16 article-title: Dynamics of changes of p53-positive cells morphofunctional condition in the cerebral cortex of the temporal lobe in rats affected by carotid ischemia-reperfusion publication-title: Patol Fiziol Eksp Ter – volume: 29 start-page: 1596 year: 2013 end-page: 1601 ident: bib5 article-title: Effects of the combinations between astragaloside Ⅳ and three active components in notoginseng on oxidative stress and Nrf2/HO-1 pathway after cerebral ischemic-reperfusion in mice publication-title: Chin Pharmacol Bull – volume: 26 start-page: 873 issue: 2 year: 2016 ident: 10.1016/j.apjtm.2016.03.024_bib11 article-title: Loss of either Rac1 or Rac3 GTPase differentially affects the behavior of mutant mice and the development of functional GABAergic networks publication-title: Cereb Cortex – volume: 16 start-page: 2033 issue: 11 year: 2012 ident: 10.1016/j.apjtm.2016.03.024_bib18 article-title: Effects of oxidative stress and Rac1/2 on venous wall and their roles in traumatic deep vein thrombosis publication-title: Chin J Tissue Eng Res – volume: 49 start-page: 645 issue: 5 year: 2014 ident: 10.1016/j.apjtm.2016.03.024_bib6 article-title: Effect of adenosine preconditioning on endogenous neural stem cell proliferation in rats after focal cerebral ischemia-reperfusion injury publication-title: J Zhengzhou Univ Med Sci – volume: 2015 start-page: 504061 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib1 article-title: Salutary effects of cepharanthine against skeletal muscle and kidney injuries following limb ischemia/reperfusion publication-title: Evid Based Complement Alternat Med doi: 10.1155/2015/504061 – volume: 15 start-page: 165 issue: 1 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib3 article-title: Pretreatment of parecoxib attenuates hepatic ischemia/reperfusion injury in rats publication-title: BMC Anesthesiol doi: 10.1186/s12871-015-0147-0 – volume: 8 start-page: 65 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib8 article-title: Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2015.00065 – volume: 52 start-page: 188 issue: 3 year: 2013 ident: 10.1016/j.apjtm.2016.03.024_bib14 article-title: An evaluation of the impact of cerebrovascular disease deaths on life expectancy in China publication-title: Chin J Intern Med – volume: 26 start-page: 34 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib19 article-title: The expression and function of NADPH oxidase in common cardiovascular diseases publication-title: China Med Her – volume: 8 start-page: 841 year: 2014 ident: 10.1016/j.apjtm.2016.03.024_bib7 article-title: Effect of gap junction in ischemic post-conditioning on cerebral ischemic-reperfusion injury in rats and its associated mechanism publication-title: Chin J Clin Pharmacol Ther – volume: 11 start-page: 1573 year: 2014 ident: 10.1016/j.apjtm.2016.03.024_bib20 article-title: The review on the cell signal transduction pathway related to free radicals publication-title: Chin J Cell Biol – volume: 34 start-page: 6 issue: 1 year: 2014 ident: 10.1016/j.apjtm.2016.03.024_bib12 article-title: Experience and improvement of preparation of the cerebral ischemia model by string-fastenings method for middle cerebral artery occlusion publication-title: J Hunan Univ Chin Med – volume: 8 start-page: 12970 issue: 8 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib21 article-title: The role of great auricular-facial nerve neurorrhaphy in facial nerve damage publication-title: Int J Clin Exp Med – volume: 42 start-page: 207 issue: 2 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib4 article-title: Effects of gradual low-flow reperfusion postconditioning on ischemia-reperfusion injury involving incomplete testicular torsion in rabbits publication-title: J Med Ultrason doi: 10.1007/s10396-014-0591-3 – volume: 7 start-page: 1345 year: 2008 ident: 10.1016/j.apjtm.2016.03.024_bib9 article-title: Inhibitive action of atorvastatin on NADPH oxidase-derived superoxide anion in ischemic brain tissue after reperfusion in rats publication-title: Chin J Pathophysiol – volume: 59 start-page: 19 issue: 2 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib16 article-title: Dynamics of changes of p53-positive cells morphofunctional condition in the cerebral cortex of the temporal lobe in rats affected by carotid ischemia-reperfusion publication-title: Patol Fiziol Eksp Ter – volume: 120 start-page: 97 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib17 article-title: Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats publication-title: Brain Res Bull doi: 10.1016/j.brainresbull.2015.11.007 – volume: 21 start-page: 12114 issue: 42 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib15 article-title: Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: a review publication-title: World J Gastroenterol doi: 10.3748/wjg.v21.i42.12114 – volume: 5 start-page: 8 issue: 1 year: 2015 ident: 10.1016/j.apjtm.2016.03.024_bib2 article-title: Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage publication-title: Acta Pharm Sin B doi: 10.1016/j.apsb.2014.11.002 – volume: 29 start-page: 1596 issue: 11 year: 2013 ident: 10.1016/j.apjtm.2016.03.024_bib5 article-title: Effects of the combinations between astragaloside Ⅳ and three active components in notoginseng on oxidative stress and Nrf2/HO-1 pathway after cerebral ischemic-reperfusion in mice publication-title: Chin Pharmacol Bull – volume: 31 start-page: 66 issue: 1 year: 2014 ident: 10.1016/j.apjtm.2016.03.024_bib10 article-title: Effect of electroacupuncture on Rac-1 mRNA expression in cerebral cortex and cervical spinal cord of rats with hypertension-induced cerebral infarction publication-title: J Guangzhou Univ Tradit Chin Med – volume: 23 start-page: 64 issue: 6 year: 2009 ident: 10.1016/j.apjtm.2016.03.024_bib13 article-title: Influence of electroacupuncture at Quchi and Zusanli on neurologic deficit impairment in rats with cerebral ischemia-reperfusion injury publication-title: Acta Univ Tradit Med Sin Pharmacol Shanghai |
| SSID | ssj0000329973 |
| Score | 2.0420191 |
| Snippet | Objective: To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of... To discuss the mechanism of low molecular weight GTP binding protein RAC1 in the injury of neural function based on building the rat model of cerebral ischemia... |
| SourceID | proquest pubmed crossref elsevier chongqing |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 460 |
| SubjectTerms | Cerebral ischemia reperfusion function ischemia Neural function RAC1 RAC1;Cerebral reperfusion;Neural |
| Title | Mechanism of low molecular weight GTP binding protein RAC1 in injury of neural function of rats with cerebral ischemia reperfusion |
| URI | http://lib.cqvip.com/qk/71792X/201605/89848289504849544853484950.html https://dx.doi.org/10.1016/j.apjtm.2016.03.024 https://www.ncbi.nlm.nih.gov/pubmed/27261857 https://www.proquest.com/docview/1794122554 https://www.proquest.com/docview/1808616133 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELZWewAuiDflJSNxJDSOHcc5rgrLCqkIwVZaTpbt2ChVm3b70N448MuZceJKHLYHLnnJI1ueyTczHs-YkHcs1KYphclEY3wmnBFZbWqZ2cJFdapcjrnD06_yYia-XJVXJ2SScmFwW-WA_T2mR7QevoyH2Ryv23b8A5OLK4kHzXLUNFgTVIgKpfzDb3ZYZ8k5AG4MNMdkZCRIxYfiNi-znu8wI53JWOwUM9_vAvB0v65BddymrG4zRqNSOn9A7g_WJD3rB_yQnPjuEbkzHeLlj8mfqcfM3na7pKtAF6sbukzH4dKbuChKP19-o7aNuS00Fm1oO_r9bMIo3NtuDlOOpFj2EjpCLYicxE8gOluKy7jU-Q2Gnxe0BVfZL1tDN37tN2GPK3FPyOz80-XkIhtOXcicUGyXKYNF65k3TFrVSMVE0XCTGyscr7kxeR0Ct8GqwISpHbRkQTAjAsZcfc35U3LarTr_nFALzmCNBo4VUjS8MLKxCvwrqxyAsK9G5P1hqvW6r66hFVCgG1gCtoD3Bu5jyeNTPiJF4oZ2QwVzPEhjodNWtbmO7NTITp1zDezEPhJR6uJoc5nYrP-RQw0q5jjh2yQUGv5QDLuYzq_2W42QxwA2y2NtFLiWYHxzPiLPeok6jLaowMtVZfXif4f2ktzDt36b5ityutvs_WswpXb2TfxX4Prx5-wv59oauA |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLfGkBgXNL4LDIzEkdA4dlznOFUbBdYJQSftZtmOjVK1aemHduPAX857TlJph_XAKVHiJ1t-9u99-T0T8oGFwpS5MIkojU-EMyIpTCETm7koTpVLMXd4fClHV-LrdX59QIZdLgweq2yxv8H0iNbtl347m_1lVfV_YnLxQOJFsxwljbhH7gvYvrg7P_1hO0dLygFxY6Q5ZiMjRVd9KJ7zMsvpBlPSmYzVTjH1_QiQp_71G2THXdLqLm00SqXzY_KoVSfpaTPix-TA10_Ig3EbMH9K_o49pvZW6zldBDpb3NB5dx8uvYleUfp58p3aKia30Fi1oarpj9Mho_Cs6inMOZJi3UvoCMUgshI_wdpZU_TjUudXGH-e0QpsZT-vDF35pV-FLbrinpGr87PJcJS01y4kTii2SZTBqvXMGyatKqViIiu5SY0VjhfcmLQIgdtgVWDCFA5asiCYEQGDrr7g_Dk5rBe1f0moBWuwQA3HCilKnhlZWgUGllUOUNgPeuTjbqr1simvoRVQoB2YA7iA-Qb2Y87jW9ojWccN7doS5niTxkx3Z9WmOrJTIzt1yjWwE_voiLou9jaXHZv1rYWoQcbsJ3zfLQoNWxTjLqb2i-1aI-YxwM18XxsFtiVo35z3yItmRe1Gmw3AzFX54NX_Du0dORpNxhf64svlt9fkIf5pzmy-IYeb1dafgF61sW_jvvkHY30cwA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mechanism+of+low+molecular+weight+GTP+binding+protein+RAC1+in+injury+of+neural+function+of+rats+with+cerebral+ischemia+reperfusion&rft.jtitle=Asian+Pacific+journal+of+tropical+medicine&rft.au=Li%2C+Ya-Hong&rft.au=Qiao%2C+Lu-Jun&rft.au=Lin%2C+Xiao-Ying&rft.date=2016-05-01&rft.issn=1995-7645&rft.volume=9&rft.issue=5&rft.spage=474&rft.epage=477&rft_id=info:doi/10.1016%2Fj.apjtm.2016.03.024&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F71792X%2F71792X.jpg |