Interleukin-6 Signaling in Triple Negative Breast Cancer Cells Elicits the Annexin A1/Formyl Peptide Receptor 1 Axis and Affects the Tumor Microenvironment

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 10; p. 1705
• Main Authors: Vecchi, Lara, Mota, Sara Teixeira Soares, Zóia, Mariana Alves Pereira, Martins, Isabella Castro, de Souza, Jessica Brito, Santos, Tiago Góss, Beserra, Adriano de Oliveira, de Andrade, Victor Piana, Goulart, Luiz Ricardo, Araújo, Thaise Gonçalves
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.05.2022; MDPI
• Subjects: Annexin A1; Antibodies; autocrine signaling; Autocrine signalling; Breast cancer; Fibroblasts; formyl peptide receptor; Genotype & phenotype; IL-6; Interleukin 6; Interleukin 6 receptors; Medical prognosis; Medical research; Metastasis; Peptides; Proteins; Signal transduction; STAT3; Stat3 protein; Tumor microenvironment; Tumors; United States > US; breast cancer; formyl peptide receptor; autocrine signaling; Annexin A1; IL-6; STAT3

Annexin A1 (AnxA1) is a pleiotropic protein that exerts essential roles in breast cancer (BC) growth and aggressiveness. In our previous work, we described the autocrine signaling of AnxA1 through formyl peptide receptor 1 (FPR1) in the triple-negative (TN) BC cell line, MDA-MB-231. Here, we aimed t...