Microsatellite instability in colorectal cancer: improved assessment using fluorescent polymerase chain reaction

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 109; no. 2; p. 465
• Main Authors: Cawkwell, L, Li, D, Lewis, F A, Martin, I, Dixon, M F, Quirke, P
• Format: Journal Article
• Language: English
• Published: United States 01.08.1995
• Subjects: Adenocarcinoma - genetics; Aged; Alleles; Colorectal Neoplasms - genetics; DNA, Satellite; Female; Fluorescence; Humans; Image Interpretation, Computer-Assisted; Polymerase Chain Reaction; Prognosis

Microsatellite instability was first described in hereditary nonpolyposis colorectal cancers and sporadic colorectal cancers, in which it was associated with a good prognosis. The aim of this study was to assess the advantages of a novel fluorescent assay for detecting microsatellite instability. El...