Autophagy Mediates Escherichia Coli -Induced Cellular Inflammatory Injury by Regulating Calcium Mobilization, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress

• Published in: International journal of molecular sciences Vol. 23; no. 22; p. 14174
• Main Authors: Liu, Jianguo, Qiu, Rendong, Liu, Ran, Song, Pengjie, Lin, Pengfei, Chen, Huatao, Zhou, Dong, Wang, Aihua, Jin, Yaping
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.11.2022; MDPI
• Subjects: Animals; Autophagy; Autophagy - physiology; Bacterial infections; Biosynthesis; Calcium (extracellular); Calcium (mitochondrial); Calcium - metabolism; Calcium imaging; Calcium ions; Calcium mobilization; Cattle; Chains; Cytochrome; Cytochrome c; Cytokines; DNA biosynthesis; E coli; Electron transport; Endometritis; Endometritis - pathology; Endometrium; Endoplasmic reticulum; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - physiology; Epithelial cells; Epithelium; Escherichia coli; Escherichia coli Infections - complications; Female; Gene expression; Homeostasis; IL-1β; Infections; Inflammasomes; Inflammation; Inflammation - metabolism; Inflammatory response; Interleukin 18; Metabolism; Mitochondria; Mitochondria - pathology; Mitochondrial DNA; mitochondrial dysfunction; NF-κB protein; Proteins; Reproductive disorders; Uterus; endometritis; mitochondrial dysfunction; autophagy; calcium mobilization; inflammation; endoplasmic reticulum stress

Bovine endometritis is a reproductive disorder that is induced by mucus or purulent inflammation of the uterine mucosa. However, the intracellular control chain during inflammatory injury remains unclear. In the present study, we found that activated the inflammatory response through the assembly of...