Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Postmenopausal Women

• Published in: The journal of clinical endocrinology and metabolism Vol. 92; no. 1; pp. 255 - 263
• Main Authors: Cust, Anne E., Kaaks, Rudolf, Friedenreich, Christine, Bonnet, Fabrice, Laville, Martine, Lukanova, Annekatrin, Rinaldi, Sabina, Dossus, Laure, Slimani, Nadia, Lundin, Eva, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Joulin, Virginie, Linseisen, Jakob, Rohrmann, Sabine, Pischon, Tobias, Boeing, Heiner, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Benetou, Vassiliki, Palli, Domenico, Berrino, Franco, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Quirós, J. Ramón, Mendez, Michelle A., Sánchez, María-José, Larrañaga, Nerea, Tormo, M. J., Ardanaz, Eva, Bueno-de-Mesquita, H. Bas, Peeters, Petra H. M., van Gils, Carla H., Khaw, Kay-Tee, Bingham, Sheila, Allen, Naomi, Key, Tim, Jenab, Mazda, Riboli, Elio
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.01.2007; Endocrine Society
• Subjects: Adiponectin; Adiponectin - blood; Adipose tissue; Aged; Biological and medical sciences; Body Mass Index; Case-Control Studies; Diabetes mellitus (non-insulin dependent); Endocrinopathies; Endometrial cancer; Endometrial Neoplasms - blood; Endometrial Neoplasms - etiology; Endometrial Neoplasms/blood/etiology; Endometrium; Estrone; Female; Fundamental and applied biological sciences. Psychology; Humans; Insulin resistance; Insulin-like growth factors; Medical sciences; Menstrual cycle; Middle Aged; Obesity; Ovarian cancer; Polycystic ovary syndrome; Post-menopause; Postmenopause - blood; Premenopause - blood; Prospective Studies; Regression analysis; Risk Factors; Statistical analysis; Testosterone; Uterine cancer; Vertebrates: endocrinology; Human; Adipocytokine; Endometrium cancer; Malignant tumor; Epidemiology; Adiponectin; Female genital diseases; Blood plasma; Risk factor; Uterine diseases; Postmenopause; Adult; Female; Woman; Endocrinology

Background: Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer. Methods: We conducted a case-control study nested within the Europ...