Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling - Aguiar, Aderbal S.; Castro, Adalberto A.; Moreira, Eduardo L.; Glaser, Viviane; Santos, Adair R.S.; Tasca, Carla I.; Latini, Alexandra; Prediger, Rui D.S. (Mechanisms of ageing and development, 2011)
Keywords: Aged; Aging; Aging - genetics; Aging - physiology; Aging - psychology; AKT protein; Animals; BDNF; Biological and medical sciences; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - physiology; Cyclic AMP Response Element-Binding Protein - physiology; Development. Metamorphosis. Moult. Ageing; Female; Fundamental and applied biological sciences. Psychology; Glutamate; Hippocampus; Hippocampus - physiology; Humans; Learning - physiology; Learning and memory; Memory - physiology; Muscle, Skeletal - physiology; Neuronal Plasticity - physiology; Physical Conditioning, Animal - physiology; Physical Conditioning, Animal - psychology; Physical exercise; Proto-Oncogene Proteins c-akt - physiology; Rats; Rats, Wistar; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction; Spatial Behavior - physiology; Synaptic plasticity; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Physical exercise; Learning and memory; LTM; BDNF; CNS; LTP; AKT; MAPK; Glutamate; STM; PI3-K; CREB; Exe; Sed; Synaptic plasticity; Aging; CaMK-IV; MLSS; Hippocampus; Senescence; Rat; Central nervous system; Space perception; Encephalon; Signal transduction; Acquisition process; Brain derived neurotrophic factor; Transcription factor CREB; Intensity; Ageing; Rodentia; Vertebrata; Mammalia; Excitatory aminoacid; Neurotransmitter; Perceptive learning; Spatial memory