The Diverse Calpain Family in Trypanosomatidae: Functional Proteins Devoid of Proteolytic Activity?

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 2; p. 299
• Main Authors: Ennes-Vidal, Vítor, Branquinha, Marta Helena, Dos Santos, André Luis Souza, d'Avila-Levy, Claudia Masini
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2021; MDPI
• Subjects: Calcium; Calpain; Cell division; Chagas disease; Chemotherapy; Coronaviruses; cysteine peptidase; Drug dosages; Gene expression; Genomes; Leishmania; Mammals; Parasites; Parasitic diseases; Proteins; Proteolysis; Review; Toxicity; Tropical diseases; Trypanosoma; Virulence; Trypanosoma; cysteine peptidase; chemotherapy; Leishmania

Calpains are calcium-dependent cysteine peptidases that were originally described in mammals and, thereafter, their homologues were identified in almost all known living organisms. The deregulated activity of these peptidases is associated with several pathologies and, consequently, huge efforts hav...