Virological Features and Clinical Manifestations Associated with Human Metapneumovirus: A New Paramyxovirus Responsible for Acute Respiratory-Tract Infections in All Age Groups
The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kind...
Saved in:
| Published in | The Journal of infectious diseases Vol. 186; no. 9; pp. 1330 - 1334 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chicago, IL
The University of Chicago Press
01.11.2002
University of Chicago Press Oxford University Press |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged <5 years and elderly subjects aged >65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged <15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients |
|---|---|
| AbstractList | The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged P < 5 years and elderly subjects aged P < 5 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged P < 15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients. The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged <5 years and elderly subjects aged >65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged <15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients.The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged <5 years and elderly subjects aged >65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged <15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients. The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged <5 years and elderly subjects aged >65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged <15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients. The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged <5 years and elderly subjects aged >65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged <15 months. These findings suggest that HMPV can be associated with severe lower-respiratory-tract infections in very young children, the elderly, and immunocompromised patients |
| Author | Boivin, Guy Pelletier, Gilles Abed, Yacine Moisan, Danielle Erdman, Dean D. Peret, Teresa C. T. Côté, Stéphanie Anderson, Larry J. Ruel, Louisette |
| Author_xml | – sequence: 1 givenname: Guy surname: Boivin fullname: Boivin, Guy email: Guy.Boivin@crchul.ulaval.ca organization: Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada – sequence: 2 givenname: Yacine surname: Abed fullname: Abed, Yacine organization: Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada – sequence: 3 givenname: Gilles surname: Pelletier fullname: Pelletier, Gilles organization: Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada – sequence: 4 givenname: Louisette surname: Ruel fullname: Ruel, Louisette organization: Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada – sequence: 5 givenname: Danielle surname: Moisan fullname: Moisan, Danielle organization: Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada – sequence: 6 givenname: Stéphanie surname: Côté fullname: Côté, Stéphanie organization: Research Center in Infectious Diseases, Regional Virology Laboratory, Laval University, Quebec City, Canada – sequence: 7 givenname: Teresa C. T. surname: Peret fullname: Peret, Teresa C. T. organization: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia – sequence: 8 givenname: Dean D. surname: Erdman fullname: Erdman, Dean D. organization: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia – sequence: 9 givenname: Larry J. surname: Anderson fullname: Anderson, Larry J. organization: Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13991198$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/12402203$$D View this record in MEDLINE/PubMed |
| BookMark | eNqF0t1u0zAUB_AIDbEP4A1ABgmuCPgjtWPusoqtkzrY0JgQN5Hrngx3iV1sh61vxSPiLWWVhhBXls756STHf-9mW9ZZyLKnBL8luOTvWFEwIh9kO2TERM45YVvZDsaU5qSUcjvbDWGBMS4YF4-ybUKL1MJsJ_t1brxr3YXRqkUHoGLvISBl52jcGntbPVbWNBCiisbZgKoQnDYqwhxdmfgdTfpOWXQMUS0t9J37aXwf3qMKfYQrdKK86lbXQxF9hrBMI8ysBdQ4jyrdR7itGq-i86v8zCsd0ZFtQA9fMxZVbYuqC0CH3vXL8Dh72Kg2wJP1uZd9OfhwNp7k00-HR-NqmuuiJDHnzQxLmGMiyoaJAqDEtBANJXKGFRWME8K1EvLmoHJWNAxGxZzpsixgphlje9nrYe7Sux99Wr_uTNDQtsqC60MtKKek4OK_kJSCYyJlgi_vwYXrvU1L1JQyiRPiCT1fo37WwbxeetMpv6r_JJbAqzVQIaXTeGW1CRvHZNpJlpvf0t6F4KHZEFzfPJl6eDIJvrkHtRmyjl6Z9m_-YuApjH-PfDaYRUip3imGcTmifJT6-dA3IcL1XV_5yzpdqBjVk6_f6v39E3o-PT2tBfsN_ZPkvQ |
| CODEN | JIDIAQ |
| CitedBy_id | crossref_primary_10_4049_jimmunol_1002589 crossref_primary_10_1016_j_jcv_2004_06_007 crossref_primary_10_3389_fcimb_2022_929856 crossref_primary_10_1097_PEC_0b013e3181a3497e crossref_primary_10_1128_AAC_00793_07 crossref_primary_10_1016_j_eimc_2010_11_007 crossref_primary_10_4049_jimmunol_1800096 crossref_primary_10_1002_jmv_20586 crossref_primary_10_1002_jmv_23731 crossref_primary_10_1097_01_inf_0000126401_21779_74 crossref_primary_10_1099_jmm_0_46052_0 crossref_primary_10_1016_j_jcv_2003_12_012 crossref_primary_10_1086_382536 crossref_primary_10_1128_JVI_01123_08 crossref_primary_10_1002_jmv_20116 crossref_primary_10_7759_cureus_73292 crossref_primary_10_1097_RTI_0b013e31805467f4 crossref_primary_10_3201_eid1004_030393 crossref_primary_10_1371_journal_pone_0215822 crossref_primary_10_1002_jmv_23501 crossref_primary_10_1128_JCM_44_4_1484_1489_2006 crossref_primary_10_1128_JVI_79_16_10678_10689_2005 crossref_primary_10_4236_health_2018_106057 crossref_primary_10_1007_s10024_004_1011_2 crossref_primary_10_1128_JVI_78_24_14003_14011_2004 crossref_primary_10_1016_j_ajpath_2014_02_026 crossref_primary_10_1016_j_virusres_2004_04_019 crossref_primary_10_1007_s00705_009_0551_1 crossref_primary_10_1016_j_jcrc_2015_09_035 crossref_primary_10_1016_S1166_8598_06_44865_1 crossref_primary_10_1007_s10096_006_0116_0 crossref_primary_10_1002_ppul_21264 crossref_primary_10_1002_jmv_21457 crossref_primary_10_1128_JCM_42_3_981_986_2004 crossref_primary_10_1016_j_bbmt_2010_11_008 crossref_primary_10_1016_j_eimce_2017_01_016 crossref_primary_10_1097_01_inf_0000188158_27840_7c crossref_primary_10_1002_jmv_24969 crossref_primary_10_1371_journal_pone_0017427 crossref_primary_10_1128_JVI_79_14_8894_8903_2005 crossref_primary_10_1177_10892532241301195 crossref_primary_10_1017_S0950268812002920 crossref_primary_10_1016_j_jpedp_2017_10_008 crossref_primary_10_1007_s00705_009_0573_8 crossref_primary_10_2185_jrm_2021_035 crossref_primary_10_1128_CMR_00039_14 crossref_primary_10_1157_13115540 crossref_primary_10_1128_JVI_79_24_15114_15122_2005 crossref_primary_10_3390_v5010087 crossref_primary_10_1177_1753466621995050 crossref_primary_10_1016_j_jcv_2009_09_016 crossref_primary_10_3346_jkms_2010_25_3_342 crossref_primary_10_1159_000516821 crossref_primary_10_1038_s41467_024_54287_x crossref_primary_10_1016_j_jcv_2015_06_089 crossref_primary_10_1128_JVI_79_23_14992_14997_2005 crossref_primary_10_1016_j_cll_2004_05_002 crossref_primary_10_1111_j_1348_0421_2010_00253_x crossref_primary_10_3346_jkms_2006_21_5_838 crossref_primary_10_1002_rmv_651 crossref_primary_10_1371_journal_pone_0088342 crossref_primary_10_1016_j_jviromet_2005_05_004 crossref_primary_10_1128_CMR_00005_06 crossref_primary_10_3109_10408363_2011_640976 crossref_primary_10_3389_fimmu_2018_02466 crossref_primary_10_1093_ndt_gfi167 crossref_primary_10_1002_jmv_21242 crossref_primary_10_1590_1518_8345_2902_3153 crossref_primary_10_1128_JCM_42_12_5944_5946_2004 crossref_primary_10_1111_irv_13275 crossref_primary_10_1128_JVI_78_15_8264_8270_2004 crossref_primary_10_1111_j_1469_0691_2010_03192_x crossref_primary_10_1002_jmv_20276 crossref_primary_10_1186_s12985_014_0198_8 crossref_primary_10_1016_j_virol_2007_06_023 crossref_primary_10_56016_dahudermj_1167707 crossref_primary_10_1007_s13337_016_0348_2 crossref_primary_10_1128_JVI_00106_07 crossref_primary_10_1016_j_jemermed_2007_11_051 crossref_primary_10_1016_S1695_4033_03_78735_9 crossref_primary_10_1002_jmv_24884 crossref_primary_10_1128_CDLI_12_1_202_205_2005 crossref_primary_10_1093_infdis_jis309 crossref_primary_10_1586_eri_10_121 crossref_primary_10_1097_01_inf_0000207480_55201_f6 crossref_primary_10_1016_j_jcv_2012_09_014 crossref_primary_10_1128_JVI_79_19_12608_12613_2005 crossref_primary_10_1111_j_1348_0421_2007_tb03956_x crossref_primary_10_1016_j_antiviral_2012_01_004 crossref_primary_10_1111_j_1440_1754_2004_00461_x crossref_primary_10_1016_j_jpp_2024_04_009 crossref_primary_10_1080_07853890_2024_2398719 crossref_primary_10_1128_JVI_79_16_10190_10199_2005 crossref_primary_10_7759_cureus_52321 crossref_primary_10_1016_j_eimc_2016_05_011 crossref_primary_10_2217_17455111_1_1_63 crossref_primary_10_1099_vir_0_19504_0 crossref_primary_10_1016_j_jinf_2004_07_011 crossref_primary_10_1016_j_jcv_2006_08_016 crossref_primary_10_1016_S1166_8598_06_44864_X crossref_primary_10_1016_j_vaccine_2004_10_009 crossref_primary_10_1002_jmv_24411 crossref_primary_10_1016_j_jcv_2011_07_018 crossref_primary_10_1016_j_copbio_2003_10_010 crossref_primary_10_1016_j_idc_2005_05_009 crossref_primary_10_1097_01_revmedmi_0000237165_94641_c1 crossref_primary_10_1136_jcp_2009_066688 crossref_primary_10_1002_ppul_20546 crossref_primary_10_1128_JVI_02584_07 crossref_primary_10_3390_v4123551 crossref_primary_10_1128_JVI_00294_06 crossref_primary_10_3390_v7030996 crossref_primary_10_7883_yoken_JJID_2019_124 crossref_primary_10_3109_09563070400015890 crossref_primary_10_1111_j_1440_1754_2006_00825_x crossref_primary_10_1097_00001432_200306000_00012 crossref_primary_10_7717_peerj_7266 crossref_primary_10_1016_S1637_5017_07_72369_4 crossref_primary_10_1128_JVI_01688_08 crossref_primary_10_1371_journal_pone_0034750 crossref_primary_10_3201_eid1006_031097 crossref_primary_10_1016_S1526_0542_03_00033_2 crossref_primary_10_1128_JVI_77_20_10819_10828_2003 crossref_primary_10_1590_0037_8682_0435_2017 crossref_primary_10_1128_JVI_03491_13 crossref_primary_10_1016_S1245_1789_07_70239_1 crossref_primary_10_3201_eid0906_030009 crossref_primary_10_1016_j_med_2022_05_003 crossref_primary_10_1007_s11739_008_0197_0 crossref_primary_10_1099_vir_0_030049_0 crossref_primary_10_1177_135965350701200S06_1 crossref_primary_10_1016_j_jiph_2015_01_008 crossref_primary_10_1097_IPC_0b013e318193437b crossref_primary_10_1590_S1415_790X2006000100006 crossref_primary_10_1056_NEJMoa025472 crossref_primary_10_1128_JVI_01469_07 crossref_primary_10_1128_JCM_43_3_1138_1141_2005 crossref_primary_10_3201_eid1107_050050 crossref_primary_10_3390_v12070724 crossref_primary_10_3201_eid1003_030513 crossref_primary_10_3201_eid1004_030555 crossref_primary_10_1196_annals_1408_005 crossref_primary_10_1128_JVI_01282_17 crossref_primary_10_1093_infdis_jix358 crossref_primary_10_3390_v10120682 crossref_primary_10_1016_j_arcped_2003_12_009 crossref_primary_10_1177_135965350801300603 crossref_primary_10_1002_ppul_20456 crossref_primary_10_1097_01_inf_0000168755_01196_49 crossref_primary_10_1016_j_jcv_2007_06_006 crossref_primary_10_1128_CMR_00015_11 crossref_primary_10_1128_JCM_41_7_3043_3045_2003 crossref_primary_10_1128_JVI_01726_14 crossref_primary_10_1371_journal_pone_0017818 crossref_primary_10_3390_v4123785 crossref_primary_10_1128_JCM_43_1_455_457_2005 crossref_primary_10_1080_00365540802227110 crossref_primary_10_3390_v13010139 crossref_primary_10_1002_jmv_10572 crossref_primary_10_1086_513295 crossref_primary_10_1002_jcb_30618 crossref_primary_10_1097_01_inf_0000105103_60288_0e crossref_primary_10_1086_591186 crossref_primary_10_1086_518986 crossref_primary_10_1186_1743_422X_9_105 crossref_primary_10_1128_JVI_00676_08 crossref_primary_10_1128_JVI_00699_08 crossref_primary_10_1016_j_cmi_2020_04_005 crossref_primary_10_1016_j_diagmicrobio_2012_01_001 crossref_primary_10_1002_jmv_20667 crossref_primary_10_1128_CMR_00037_07 crossref_primary_10_1002_ppul_20597 crossref_primary_10_1007_s10096_018_3363_y crossref_primary_10_1128_JVI_01130_10 crossref_primary_10_1002_jmv_21752 crossref_primary_10_1016_S1695_4033_04_78799_8 crossref_primary_10_1016_S0755_4982_04_98824_0 crossref_primary_10_1177_0009922810368559 crossref_primary_10_1155_2014_290793 crossref_primary_10_7883_yoken_67_318 crossref_primary_10_1007_s42247_021_00169_7 crossref_primary_10_1128_JCM_00152_06 crossref_primary_10_1111_j_1348_0421_2009_00162_x crossref_primary_10_1016_S1166_8598_06_26060_5 crossref_primary_10_1128_JCM_00164_06 crossref_primary_10_1038_s41467_017_01708_9 crossref_primary_10_1111_crj_12064 crossref_primary_10_3390_pathogens2020232 crossref_primary_10_1002_jmv_21884 crossref_primary_10_3390_v4112754 crossref_primary_10_3345_kjp_2006_49_4_401 crossref_primary_10_1128_JVI_02198_08 crossref_primary_10_1038_s41598_020_59150_9 crossref_primary_10_1186_1743_422X_9_247 crossref_primary_10_3201_eid0906_030017 crossref_primary_10_1016_S0025_7753_03_73791_9 crossref_primary_10_1016_S0929_6646_09_60211_4 crossref_primary_10_1016_j_celrep_2022_111399 crossref_primary_10_1128_CMR_00081_15 crossref_primary_10_1016_j_virol_2003_12_020 crossref_primary_10_1128_CMR_00014_06 crossref_primary_10_1016_S0140_6736_03_12785_7 crossref_primary_10_1002_jmv_20685 crossref_primary_10_1016_j_jcv_2008_09_011 crossref_primary_10_1016_j_vaccine_2007_04_075 crossref_primary_10_1186_s12887_017_0843_7 crossref_primary_10_1016_S0166_3542_03_00153_0 crossref_primary_10_1128_JVI_80_4_2034_2044_2006 crossref_primary_10_4103_0255_0857_90162 crossref_primary_10_1002_jmv_20329 crossref_primary_10_1016_j_jviromet_2009_11_019 crossref_primary_10_4049_jimmunol_176_10_5848 crossref_primary_10_1093_jpids_piv027 crossref_primary_10_21518_2079_701X_2017_9_48_50 crossref_primary_10_1111_1348_0421_12542 crossref_primary_10_1128_JCM_43_1_488_490_2005 crossref_primary_10_1016_j_jcv_2005_10_007 crossref_primary_10_1097_INF_0b013e318162a164 crossref_primary_10_4049_immunohorizons_2300026 crossref_primary_10_1002_jmv_10536 crossref_primary_10_1128_JCM_41_7_2987_2991_2003 crossref_primary_10_1016_j_virol_2011_04_016 crossref_primary_10_1099_vir_0_015396_0 crossref_primary_10_1080_21505594_2016_1265725 crossref_primary_10_1007_s00705_009_0492_8 crossref_primary_10_1016_j_jcv_2011_10_010 crossref_primary_10_1128_JVI_00639_12 crossref_primary_10_1128_JCM_42_8_3532_3537_2004 crossref_primary_10_1002_ajp_20565 crossref_primary_10_1080_14760584_2017_1283223 crossref_primary_10_1128_JCM_43_3_1213_1219_2005 crossref_primary_10_1128_JCM_42_8_3406_3414_2004 crossref_primary_10_1371_journal_pone_0080371 crossref_primary_10_3390_pathogens3030633 crossref_primary_10_1016_S1637_5017_07_72376_1 crossref_primary_10_11603_1681_2727_2025_1_15151 crossref_primary_10_1016_j_jcv_2011_10_002 crossref_primary_10_1016_j_antiviral_2010_07_001 crossref_primary_10_1016_j_rmcr_2013_12_007 crossref_primary_10_1099_jmm_0_006098_0 crossref_primary_10_1128_JVI_01381_08 crossref_primary_10_1097_01_inf_0000207395_80657_cf crossref_primary_10_1128_JVI_01243_06 crossref_primary_10_1097_01_inf_0000144668_81573_6d crossref_primary_10_1159_000445059 crossref_primary_10_1016_j_jcv_2007_08_004 crossref_primary_10_1016_j_healun_2005_02_014 crossref_primary_10_1016_j_jcv_2007_08_001 crossref_primary_10_1016_j_idc_2017_05_004 crossref_primary_10_1016_S1245_1789_07_70246_9 crossref_primary_10_1007_s11908_005_0036_7 crossref_primary_10_1007_s00431_009_0949_5 crossref_primary_10_1007_BF02725660 crossref_primary_10_2217_17460794_3_4_363 crossref_primary_10_1590_S0074_02762005000700005 crossref_primary_10_1097_01_inf_0000091347_27554_ff crossref_primary_10_14776_kjpid_2013_20_3_168 crossref_primary_10_1097_01_inf_0000108190_09824_e8 crossref_primary_10_1016_j_cll_2009_10_002 crossref_primary_10_1128_JVI_79_17_10944_10951_2005 crossref_primary_10_3390_microorganisms8091280 crossref_primary_10_1111_j_1469_0691_2006_01540_x crossref_primary_10_1590_S0074_02762010000800010 crossref_primary_10_3390_v10090505 crossref_primary_10_1007_s00431_007_0427_x crossref_primary_10_1007_s00425_015_2277_5 crossref_primary_10_1007_s10096_012_1699_2 crossref_primary_10_1016_j_jcv_2008_03_002 crossref_primary_10_4049_jimmunol_0802262 crossref_primary_10_1128_JCM_41_10_4642_4646_2003 crossref_primary_10_3345_kjp_2009_52_3_330 crossref_primary_10_1016_j_virusres_2023_199215 crossref_primary_10_1093_cid_cis297 crossref_primary_10_1086_513204 crossref_primary_10_1128_CDLI_12_2_249_253_2005 crossref_primary_10_1016_j_jcv_2006_07_003 crossref_primary_10_1128_JCM_43_7_3443_3446_2005 crossref_primary_10_1165_rcmb_2007_0285OC crossref_primary_10_1111_j_1469_0691_2007_01682_x crossref_primary_10_11150_kansenshogakuzasshi_91_558 crossref_primary_10_7759_cureus_78354 crossref_primary_10_1093_infdis_jiae064 crossref_primary_10_1177_2324709619860549 crossref_primary_10_3389_fmicb_2017_00402 crossref_primary_10_1073_pnas_2106196118 crossref_primary_10_1002_jmv_21920 crossref_primary_10_3389_fcell_2021_790150 crossref_primary_10_1093_pch_8_10_613 crossref_primary_10_1128_AAC_50_2_774_777_2006 crossref_primary_10_3201_eid0909_030304 crossref_primary_10_1016_j_meegid_2019_104039 crossref_primary_10_1016_j_cmi_2024_10_023 crossref_primary_10_1128_CVI_00398_09 crossref_primary_10_1111_j_1469_0691_2005_01325_x crossref_primary_10_1007_s00705_010_0596_1 crossref_primary_10_1016_j_ijid_2014_03_1394 crossref_primary_10_3201_eid1401_070251 crossref_primary_10_7581_pard_2012_22_3_265 crossref_primary_10_1016_j_jcv_2007_01_012 crossref_primary_10_1056_NEJMoa030634 crossref_primary_10_1128_JVI_00844_06 crossref_primary_10_1128_JCM_01888_07 crossref_primary_10_1136_bmjopen_2017_019308 crossref_primary_10_1177_0885066603258009 crossref_primary_10_1016_j_virol_2006_08_004 crossref_primary_10_1016_j_jcv_2004_11_023 crossref_primary_10_1128_JCM_00809_12 crossref_primary_10_3390_v12050542 crossref_primary_10_1016_j_medmal_2006_07_008 crossref_primary_10_1086_526776 crossref_primary_10_1016_j_vaccine_2009_11_063 crossref_primary_10_1128_CMR_00045_07 crossref_primary_10_12688_f1000research_12625_1 crossref_primary_10_7717_peerj_6748 crossref_primary_10_1186_1471_2466_11_38 crossref_primary_10_1111_j_1469_0691_2005_01129_x crossref_primary_10_1371_journal_pone_0092136 crossref_primary_10_3390_pathogens9010051 crossref_primary_10_1128_JVI_79_11_6588_6597_2005 crossref_primary_10_1016_j_meegid_2011_01_016 crossref_primary_10_1086_432728 crossref_primary_10_1007_s11033_021_06776_1 crossref_primary_10_1099_vir_0_030825_0 crossref_primary_10_1542_peds_111_6_1407 crossref_primary_10_2217_ahe_09_69 crossref_primary_10_1016_j_jcv_2004_08_021 crossref_primary_10_1016_j_jped_2017_07_017 crossref_primary_10_1128_JVI_01287_06 crossref_primary_10_1002_jmv_22002 crossref_primary_10_1128_JCM_42_1_126_132_2004 crossref_primary_10_1016_j_cger_2007_02_002 crossref_primary_10_1080_00365540902849375 crossref_primary_10_1016_j_micinf_2005_07_001 crossref_primary_10_1002_jmv_23213 crossref_primary_10_1002_rmv_2090 crossref_primary_10_3201_eid1007_030983 crossref_primary_10_1007_s00705_011_1204_8 crossref_primary_10_3390_microorganisms8060824 crossref_primary_10_1097_00029330_200811010_00011 crossref_primary_10_1097_01_mot_0000186962_26493_31 crossref_primary_10_1086_379771 crossref_primary_10_1016_S0042_6822_03_00528_2 crossref_primary_10_1007_s00705_012_1492_7 crossref_primary_10_1089_hyb_2006_034 crossref_primary_10_1586_eci_09_2 crossref_primary_10_1016_j_pcl_2006_08_004 crossref_primary_10_1097_INF_0b013e3181684dac crossref_primary_10_1128_JCM_00321_09 crossref_primary_10_1186_1471_2334_10_170 crossref_primary_10_3390_microorganisms7110521 crossref_primary_10_1016_j_jinf_2005_07_001 crossref_primary_10_1128_JCM_01567_07 crossref_primary_10_1007_s00705_005_0581_2 crossref_primary_10_1016_j_vaccine_2011_11_008 crossref_primary_10_1002_jmv_23477 crossref_primary_10_1080_00365540500388750 crossref_primary_10_1007_s00705_013_1812_6 crossref_primary_10_1371_journal_pone_0244093 crossref_primary_10_1099_vir_0_2008_000778_0 crossref_primary_10_1007_s12038_008_0067_y crossref_primary_10_1016_S0002_9440_10_63750_9 crossref_primary_10_1007_s40291_013_0032_9 crossref_primary_10_1128_JCM_01251_06 crossref_primary_10_3201_eid1405_071459 crossref_primary_10_3390_v14040677 crossref_primary_10_1007_s42770_022_00689_2 crossref_primary_10_1128_CMR_17_2_390_412_2004 crossref_primary_10_1128_CVI_00145_13 crossref_primary_10_1016_j_str_2013_10_013 crossref_primary_10_1002_jmv_21194 crossref_primary_10_1590_S1806_37132013000200011 crossref_primary_10_2217_fvl_10_13 crossref_primary_10_1016_S0165_5876_09_70007_2 crossref_primary_10_1016_j_virusres_2010_03_018 crossref_primary_10_1099_vir_0_79805_0 crossref_primary_10_1002_jmv_21081 crossref_primary_10_3389_fcimb_2024_1435294 crossref_primary_10_1089_hyb_2005_24_201 crossref_primary_10_1111_j_1365_2141_2008_07295_x crossref_primary_10_1002_jmv_22176 crossref_primary_10_1016_S1637_5017_07_72370_0 crossref_primary_10_1186_2110_5820_2_30 crossref_primary_10_1157_13080214 crossref_primary_10_1016_j_micinf_2009_11_002 crossref_primary_10_1016_j_jviromet_2012_05_030 crossref_primary_10_1007_s10096_019_03693_x crossref_primary_10_3389_fmicb_2018_03294 crossref_primary_10_1016_S1245_1789_07_70240_8 crossref_primary_10_1097_01_rct_0000157087_14838_4c crossref_primary_10_30841_2307_5112_5_6_2019_193437 crossref_primary_10_1378_chest_07_0778 crossref_primary_10_1371_journal_pone_0073488 crossref_primary_10_1128_JVI_79_10_5971_5978_2005 crossref_primary_10_1016_j_idc_2004_07_001 crossref_primary_10_1007_s12254_021_00734_0 crossref_primary_10_3201_eid1208_060261 crossref_primary_10_1128_JCM_41_8_3631_3635_2003 crossref_primary_10_1111_j_1399_3046_2005_00442_x crossref_primary_10_1128_JCM_01554_07 crossref_primary_10_1016_j_patbio_2008_04_005 crossref_primary_10_2217_fmb_09_26 crossref_primary_10_1086_431981 crossref_primary_10_1086_499955 crossref_primary_10_1002_jmv_22193 |
| ContentType | Journal Article |
| Copyright | Copyright 2002 Infectious Diseases Society of America 2002 by the Infectious Diseases Society of America 2002 2003 INIST-CNRS Copyright University of Chicago, acting through its Press Nov 1, 2002 |
| Copyright_xml | – notice: Copyright 2002 Infectious Diseases Society of America – notice: 2002 by the Infectious Diseases Society of America 2002 – notice: 2003 INIST-CNRS – notice: Copyright University of Chicago, acting through its Press Nov 1, 2002 |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM K9. NAPCQ 7U9 H94 7X8 |
| DOI | 10.1086/344319 |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Virology and AIDS Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium AIDS and Cancer Research Abstracts Virology and AIDS Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE ProQuest Health & Medical Complete (Alumni) AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1537-6613 |
| EndPage | 1334 |
| ExternalDocumentID | 546026951 12402203 13991198 10_1086_344319 10.1086/344319 30085265 ark_67375_HXZ_BBP2VLQQ_7 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Canada North America America |
| GroupedDBID | --- -DZ -~X ..I .2P .55 .GJ .I3 .XZ .ZR 08P 0R~ 123 1TH 29K 2AX 2WC 36B 3O- 4.4 48X 53G 5GY 5RE 5VS 5WD 70D 85S AABZA AACGO AACZT AAHBH AAHTB AAJKP AAMVS AANCE AAOGV AAPNW AAPQZ AAPXW AAQQT AARHZ AAUAY AAUQX AAVAP AAWTL ABBHK ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABLJU ABNHQ ABNKS ABOCM ABPEJ ABPLY ABPPZ ABPQP ABPTD ABQLI ABQNK ABTLG ABVGC ABWST ABXSQ ABXVV ABZBJ ACGFO ACGFS ACGOD ACHIC ACPRK ACUFI ACUTO ACYHN ADBBV ADEYI ADGZP ADHKW ADHZD ADIPN ADNBA ADOCK ADQBN ADQXQ ADRTK ADULT ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKSI AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEUPB AEWNT AEXZC AFFNX AFFZL AFHKK AFIYH AFOFC AFXAL AFYAG AGINJ AGKEF AGORE AGQXC AGSYK AGUTN AHMBA AHMMS AHXPO AI. AIAGR AIJHB AJBYB AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APWMN AQVQM ATGXG AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BR6 BSCLL BTRTY BVRKM C45 CDBKE CS3 CZ4 D-I DAKXR DCCCD DIK DILTD DU5 D~K EBS ECGQY EE~ EJD EMOBN ENERS F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H5~ HAR HQ3 HTVGU HW0 HZ~ IH2 IOX IPSME J21 J5H JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JST JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN L7B LSO LU7 MHKGH MJL ML0 MVM N4W N9A NEJ NGC NOMLY NOYVH NU- NVLIB O0~ O9- OAUYM OAWHX OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q1. Q5Y QBD RD5 ROX ROZ RUSNO RW1 RXO SA0 SJN TCURE TEORI TJX TR2 VH1 W2D W8F WH7 X7H X7M Y6R YAYTL YKOAZ YXANX ZGI ZXP ~91 AASNB ADACV ADJQC ADRIX AFXEN DOOOF ESX JSODD M49 1KJ 41~ AAFWJ AAJQQ AAPGJ AAWDT AAYOK AAYXX ABDPE ABSMQ ACFRR ACPQN ACUTJ ACVCV ACZBC ADMTO AEKPW AFFQV AFQQW AFSHK AGKRT AGMDO AHGBF AJDVS APJGH AQDSO AQKUS AVNTJ BZKNY CITATION EIHJH H13 MBLQV OBFPC O~Y P0- TMA ZE2 IQODW CGR CUY CVF ECM EIF NPM VXZ YIF K9. NAPCQ 7U9 H94 7X8 |
| ID | FETCH-LOGICAL-c481t-6fb09ed0178f374ee80247f219b0a2736116ca79116c29b4f3e54d3c884ebc333 |
| ISSN | 0022-1899 |
| IngestDate | Fri Jul 11 10:26:55 EDT 2025 Thu Jul 10 23:26:02 EDT 2025 Mon Jun 30 08:51:23 EDT 2025 Wed Feb 19 01:26:46 EST 2025 Mon Jul 21 09:14:13 EDT 2025 Thu Apr 24 22:56:40 EDT 2025 Tue Jul 01 03:23:30 EDT 2025 Wed Sep 11 04:50:42 EDT 2024 Fri Jun 20 02:31:58 EDT 2025 Tue Aug 05 16:50:44 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Keywords | Human Lung disease Pneumovirinae Respiratory disease Virological exploration Age criterion Clinical form Epidemiology Retrospective Paramyxoviridae Bronchiolitis Virus Infection Mononegavirales Immunosuppression Viral disease Pneumovirus Pneumopathy |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c481t-6fb09ed0178f374ee80247f219b0a2736116ca79116c29b4f3e54d3c884ebc333 |
| Notes | istex:E9C43F30305BFAD01067432EE2EDA42F5A882730 ark:/67375/HXZ-BBP2VLQQ-7 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Feature-3 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| OpenAccessLink | https://academic.oup.com/jid/article-pdf/186/9/1330/18008544/186-9-1330.pdf |
| PMID | 12402203 |
| PQID | 223900196 |
| PQPubID | 41591 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_72621467 proquest_miscellaneous_18760199 proquest_journals_223900196 pubmed_primary_12402203 pascalfrancis_primary_13991198 crossref_primary_10_1086_344319 crossref_citationtrail_10_1086_344319 oup_primary_10_1086_344319 jstor_primary_30085265 istex_primary_ark_67375_HXZ_BBP2VLQQ_7 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2002-11-01 |
| PublicationDateYYYYMMDD | 2002-11-01 |
| PublicationDate_xml | – month: 11 year: 2002 text: 2002-11-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Chicago, IL |
| PublicationPlace_xml | – name: Chicago, IL – name: United States – name: Oxford |
| PublicationTitle | The Journal of infectious diseases |
| PublicationTitleAbbrev | The Journal of Infectious Diseases |
| PublicationTitleAlternate | The Journal of Infectious Diseases |
| PublicationYear | 2002 |
| Publisher | The University of Chicago Press University of Chicago Press Oxford University Press |
| Publisher_xml | – name: The University of Chicago Press – name: University of Chicago Press – name: Oxford University Press |
| SSID | ssj0004367 |
| Score | 2.2961934 |
| Snippet | The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients... |
| SourceID | proquest pubmed pascalfrancis crossref oup jstor istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1330 |
| SubjectTerms | Acute Disease Age Distribution Animals Biological and medical sciences Cell Line Cell lines Cercopithecus aethiops Concise Communications DNA Primers Epidemiology Human respiratory syncytial virus Human viral diseases Humans Infections Infectious diseases Medical sciences Metapneumovirus Metapneumovirus - classification Metapneumovirus - genetics Metapneumovirus - pathogenicity Older adults Paramyxoviridae Infections - physiopathology Paramyxoviridae Infections - virology Pathogens Phylogeny Pneumology Pneumonia Respiratory system : syndromes and miscellaneous diseases Respiratory Tract Infections - virology Reverse Transcriptase Polymerase Chain Reaction Viral diseases Viral diseases of the respiratory system and ent viral diseases Virology Viruses |
| Title | Virological Features and Clinical Manifestations Associated with Human Metapneumovirus: A New Paramyxovirus Responsible for Acute Respiratory-Tract Infections in All Age Groups |
| URI | https://api.istex.fr/ark:/67375/HXZ-BBP2VLQQ-7/fulltext.pdf https://www.jstor.org/stable/30085265 https://www.ncbi.nlm.nih.gov/pubmed/12402203 https://www.proquest.com/docview/223900196 https://www.proquest.com/docview/18760199 https://www.proquest.com/docview/72621467 |
| Volume | 186 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELb2QyCkCcFgkA2GH4C3TEnsOjFv3YAVWFGHuqnjJUocByq2tGqbaeOv4k_kHMdJuq1S4SVNEzdpel_Pd77v7hB6LVjKmWSpzQQnNvWpY0cB9-0EbFOSCOLzVCU4d7-yzgn9PGgNVlY3GqylfBbvid935pX8j1ThGMhVZcn-g2Sri8IB2Af5whYkDNulZHw6nFS6S9lyOfjORTTgwOQ7diPFXZnOSsKbEYbhnOsl_K6cReNM5hejy-Ekn-pkdUV87EWT6OL6Sh9WK_2aTnuuC4W3heIYfKtj9XZfpVyBytH8Lk1RV81B2z-kXuSaNm3hOiutLFyhPwZ3KqNG9Qr-aHipax0c5lUIoB3rddqzqMkN6MminLgG4qFKdGyQ-TUj4WiUw_UNw8mseHhl6p_BaP_nMqwVk6ngBroB0540Ct63wSYh8zMAa0CdN_Q5ePBOwzaAt_TOeccpwmCEgjnG65nVsAluTLgVDTKa_FK8Or8Vdgbfw_39nnd6dHwc-qto3QOvRzXkeP_pS53mS5hvit-rx2q0ytJ3nrOt1pWauDI0W5O_uTGOpgC_VHdtWexWFeZV_xF6WOIAtzXIH6MVmW2ie7pT6vUmut8tOSBP0J8G6rFBPQbUY4N6PI96XKMeK9TjAvX4Burf4TYGzOM5zOMG5jFgHheYx7cwj2vM42GGAfMYMI815p-ik48f-gcdu-w7YgsauDObpbHDZQJzVZASn0oZgCHrpzC3x04E5j5zXSYin6sXj8c0JbJFEyKCgMpYEEK20Fo2yuRzhGUiaQBjBGEpZbCX-EKmNHCE46UtySz0xkgsFGVRftUb5jwsyCEBC7VkLfSqGjfWZWhujXhbCLw6vQhcFtoqEFENJMrt8ljLQtvwoyy8_O4ccuph4OG4Lg8stGOgFJYqchqC78GLClzw_auzMH-poGSUSdAooRsoVh7ni0f4HvOUPWehZxqh9b1VaNhzyPayz76DHtQK5QVam01y-RKcilm8W_zV_gIYTiiP |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Virological+Features+and+Clinical+Manifestations+Associated+with+Human+Metapneumovirus%3A+A+New+Paramyxovirus+Responsible+for+Acute+Respiratory-Tract+Infections+in+All+Age+Groups&rft.jtitle=The+Journal+of+infectious+diseases&rft.au=Boivin%2C+Guy&rft.au=Abed%2C+Yacine&rft.au=Pelletier%2C+Gilles&rft.au=Ruel%2C+Louisette&rft.date=2002-11-01&rft.pub=The+University+of+Chicago+Press&rft.issn=0022-1899&rft.eissn=1537-6613&rft.volume=186&rft.issue=9&rft.spage=1330&rft.epage=1334&rft_id=info:doi/10.1086%2F344319&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_HXZ_BBP2VLQQ_7 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1899&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1899&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1899&client=summon |