Hepatoprotective effects of loach (Misgurnus anguillicaudatus) lyophilized powder on dimethylnitrosamine-induced liver fibrosis in rats

• Published in: Archives of pharmacal research Vol. 44; no. 8; pp. 1 - 12
• Main Authors: Zhang, Qian, Shang, Meng-Meng, Ling, Qu-Fei, Wu, Xiao-Ping, Liu, Chun-Yu
• Format: Journal Article
• Language: English
• Published: Seoul Pharmaceutical Society of Korea 01.08.2021; 대한약학회
• Subjects: actin; alanine transaminase; albumins; Animals; aspartate transaminase; blood serum; collagen; Cypriniformes - metabolism; Dimethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; extracellular matrix; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; fibrosis; freeze drying; gelatinase A; gelatinase B; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - pathology; hepatocytes; Hepatocytes - drug effects; Hepatocytes - pathology; hyaluronic acid; hydroxyproline; immunohistochemistry; laminin; liver cirrhosis; Liver Cirrhosis, Experimental - prevention & control; Male; Medicine; Misgurnus anguillicaudatus; muscles; Pharmacology/Toxicology; Pharmacy; Powders - administration & dosage; Powders - isolation & purification; Powders - pharmacology; protein content; Rats; Rats, Wistar; Research Article; therapeutics; Transforming Growth Factor beta1 - metabolism; Western blotting; 약학; Loach; Mechanism of anti-hepatic fibrosis; lyophilized powder; Rats; Hepatic stellate cells; Extracellular matrix; Liver fibrosis; Loach (Misgurnus anguillicaudatus) lyophilized powder

This study investigates the hepatoprotective effects and the potential therapeutic mechanisms of loach ( Misgurnus anguillicaudatus ) lyophilized powder (MLP) on dimethylnitrosamine (DMN) induced liver fibrosis in rats. After treatment with MLP (50, 100, 200 mg/kg), alanine aminotransferase (ALT), a...