Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice

• Published in: International journal of molecular sciences Vol. 14; no. 12; pp. 24380 - 24398
• Main Authors: Cao, Yunshan, Tao, Lichan, Shen, Shutong, Xiao, Junjie, Wu, Hang, Li, Beibei, Wu, Xiangqi, Luo, Wen, Xiao, Qi, Hu, Xiaoshan, Liu, Hailang, Nie, Junwei, Lu, Shuangshuang, Yuan, Baiyin, Han, Zhonglin, Xiao, Bo, Yang, Zhongzhou, Li, Xinli
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.12.2013; Molecular Diversity Preservation International (MDPI)
• Subjects: Ablation; Animals; Animals, Newborn; Apoptosis; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - metabolism; Arrhythmias, Cardiac - pathology; Cardiac arrhythmia; Cardiomyocytes; Cells, Cultured; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Heart - growth & development; Heart - physiopathology; Heart failure; Heart Failure - etiology; Heart Failure - metabolism; Heart Failure - pathology; heart growth; infant heart failure; JNK Mitogen-Activated Protein Kinases - metabolism; Kinases; Life sciences; Metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Monomeric GTP-Binding Proteins - deficiency; Monomeric GTP-Binding Proteins - genetics; Monomeric GTP-Binding Proteins - metabolism; mTORC1; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Neuropeptides - deficiency; Neuropeptides - genetics; Neuropeptides - metabolism; Peptides; Phosphatase; Phosphoric Monoester Hydrolases - metabolism; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - metabolism; Ras Homolog Enriched in Brain Protein; Rheb1; Survival analysis; China

Ras homologue enriched in brain 1 (Rheb1) plays an important role in a variety of cellular processes. In this study, we investigate the role of Rheb1 in the post-natal heart. We found that deletion of the gene responsible for production of Rheb1 from cardiomyocytes of post-natal mice resulted in mal...