An Update on the Potential of Tangeretin in the Management of Neuroinflammation-Mediated Neurodegenerative Disorders

• Published in: Life (Basel, Switzerland) Vol. 14; no. 4; p. 504
• Main Authors: Wani, Irshad, Koppula, Sushruta, Balda, Aayushi, Thekkekkara, Dithu, Jamadagni, Ankush, Walse, Prathamesh, Manjula, Santhepete Nanjundaiah, Kopalli, Spandana Rajendra
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Alzheimer's disease; Attention; Bioflavonoids; c-Jun protein; Care and treatment; Chemical properties; Citrus; Citrus fruits; Degeneration; Development and progression; Diabetes mellitus; Enzymes; Flavones; Flavonoids; Functional foods; Functional foods & nutraceuticals; Health aspects; Hydrocarbons; Inflammation; Isoflavones; JNK protein; Kinases; Literature reviews; MAP kinase; Metabolism; Metabolites; microglia; Nervous system; Nervous system diseases; neurodegeneration; Neurodegenerative diseases; neuroinflammation; Neurons; Neurophysiology; Neuroprotection; Oxidants; Oxidative stress; Oxidizing agents; Parkinson's disease; Permeability; Peroxisome proliferator-activated receptors; Pharmacokinetics; Pharmacology; Physiological aspects; Prevention; Protein kinases; Tangeretin; Transcription; Transcription factors; South Korea; India; Citrus fruits; antioxidant; neuroinflammation; anti-inflammatory; neurodegeneration; flavonoids; microglia; tangeretin

Neuroinflammation is the major cause of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Currently available drugs present relatively low efficacy and are not capable of modifying the course of the disease or delaying its progression. Identifying well-tolerated and...