Activation of Hypoxia-Inducible Factor-1α Signaling Pathway Has the Protective Effect of Intervertebral Disc Degeneration

• Published in: International journal of molecular sciences Vol. 22; no. 21; p. 11355
• Main Authors: Kim, Jin-Woo, An, Hyun-Ju, Yeo, HyunJeong, Jeong, Yunhui, Lee, HyeonHae, Lee, Jusung, Nam, Kisik, Lee, Jongheon, Shin, Dong-Eun, Lee, Soonchul
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.10.2021; MDPI
• Subjects: Adenosine triphosphate; Aggrecan; Animals; Apoptosis; ATP; Cell Line; Cell lines; Chemical compounds; Collagen; Collagen (type II); Collagen Type II - metabolism; Degeneration; Enzymes; FasL protein; Fluoroscopy; Gene expression; Gene Expression - genetics; Gene Expression Regulation - genetics; Gene transfer; Glycolysis; Histology; Humans; Hypoxia; hypoxia inducible factor-1α; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - pharmacology; Hypoxia-inducible factor 1a; Immunohistochemistry; intervertebral disc; Intervertebral Disc - pathology; Intervertebral Disc Degeneration - prevention & control; Intervertebral discs; Lysis; Magnetic resonance imaging; Male; Morphology; Mutation; Nuclei (cytology); Nucleus pulposus; Nucleus Pulposus - metabolism; Oxygen tension; Pharmacology; Point mutation; protection; Proteins; Rats; Rats, Sprague-Dawley; Segments; Signal transduction; Signal Transduction - physiology; Sox9 protein; Spinal stenosis; Vascular endothelial growth factor; hypoxia inducible factor-1α; intervertebral disc; protection; degeneration

Intervertebral discs (IVDs) have poor nutrient diffusion, because the nucleus pulposus (NP) lacks direct vascular supply and likely generates adenosine triphosphate by anaerobic glycolysis. Regulation of glycolysis is mediated by hypoxia-inducible factor-1α (HIF-1α), a transcription factor that resp...