What Do We Know about Classical and Non-Classical Progesterone Receptors in the Human Female Reproductive Tract? A Review

The progesterone hormone regulates the human menstrual cycle, pregnancy, and parturition by its action via the different progesterone receptors and signaling pathways in the female reproductive tract. Progesterone actions can be exerted through classical and non-classical receptors, or even a combin...

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Published inInternational journal of molecular sciences Vol. 22; no. 20; p. 11278
Main Authors Medina-Laver, Yassmin, Rodríguez-Varela, Cristina, Salsano, Stefania, Labarta, Elena, Domínguez, Francisco
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 19.10.2021
MDPI
Subjects
Cervix
Cloning
Cytochrome
Estrogens
Female
female infertility
Gene expression
Gene regulation
Genitalia, Female - metabolism
Genitalia, Female - physiopathology
human
Humans
Infertility
Infertility, Female - metabolism
Infertility, Female - pathology
Kinases
Ligands
Membranes
Menstrual cycle
Menstruation
Nuclear receptors
Ovaries
Parturition
Physiology
Placenta
Pregnancy
Progesterone
Progesterone - metabolism
progesterone receptor
Progesterone receptors
Progestin
Progestin receptors
Proteins
Receptors, Progesterone - metabolism
reproduction
Reproductive system
Review
Signal transduction
Sperm
Transcription activation
Uterus
female infertility
human
progesterone receptor
progesterone
reproduction
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Abstract The progesterone hormone regulates the human menstrual cycle, pregnancy, and parturition by its action via the different progesterone receptors and signaling pathways in the female reproductive tract. Progesterone actions can be exerted through classical and non-classical receptors, or even a combination of both. The former are nuclear receptors whose activation leads to transcriptional activity regulation and thus in turn leads to slower but long-lasting responses. The latter are composed of progesterone receptors membrane components (PGRMC) and membrane progestin receptors (mPRs). These receptors rapidly activate the appropriate intracellular signal transduction pathways, and they can subsequently initiate specific cell responses or even modulate genomic cell responses. This review covers our current knowledge on the mechanisms of action and the relevance of classical and non-classical progesterone receptors in female reproductive tissues ranging from the ovary and uterus to the cervix, and it exposes their crucial role in female infertility.
AbstractList The progesterone hormone regulates the human menstrual cycle, pregnancy, and parturition by its action via the different progesterone receptors and signaling pathways in the female reproductive tract. Progesterone actions can be exerted through classical and non-classical receptors, or even a combination of both. The former are nuclear receptors whose activation leads to transcriptional activity regulation and thus in turn leads to slower but long-lasting responses. The latter are composed of progesterone receptors membrane components (PGRMC) and membrane progestin receptors (mPRs). These receptors rapidly activate the appropriate intracellular signal transduction pathways, and they can subsequently initiate specific cell responses or even modulate genomic cell responses. This review covers our current knowledge on the mechanisms of action and the relevance of classical and non-classical progesterone receptors in female reproductive tissues ranging from the ovary and uterus to the cervix, and it exposes their crucial role in female infertility.
Author Medina-Laver, Yassmin
Labarta, Elena
Salsano, Stefania
Rodríguez-Varela, Cristina
Domínguez, Francisco
AuthorAffiliation 2 IVI RMA Valencia, 46015 Valencia, Spain
1 IVI Foundation—IIS La Fe, 46026 Valencia, Spain; yassmin.medina@ivirma.com (Y.M.-L.); cristina.rodriguez@ivirma.com (C.R.-V.); stefaniasalsano@gmail.com (S.S.); elena.labarta@ivirma.com (E.L.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34681937$$D View this record in MEDLINE/PubMed
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Keywords female infertility
human
progesterone receptor
progesterone
reproduction
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Snippet The progesterone hormone regulates the human menstrual cycle, pregnancy, and parturition by its action via the different progesterone receptors and signaling...
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SubjectTerms Cervix
Cloning
Cytochrome
Estrogens
Female
female infertility
Gene expression
Gene regulation
Genitalia, Female - metabolism
Genitalia, Female - physiopathology
human
Humans
Infertility
Infertility, Female - metabolism
Infertility, Female - pathology
Kinases
Ligands
Membranes
Menstrual cycle
Menstruation
Nuclear receptors
Ovaries
Parturition
Physiology
Placenta
Pregnancy
Progesterone
Progesterone - metabolism
progesterone receptor
Progesterone receptors
Progestin
Progestin receptors
Proteins
Receptors, Progesterone - metabolism
reproduction
Reproductive system
Review
Signal transduction
Sperm
Transcription activation
Uterus
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Title What Do We Know about Classical and Non-Classical Progesterone Receptors in the Human Female Reproductive Tract? A Review
URI https://www.ncbi.nlm.nih.gov/pubmed/34681937
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Volume 22
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