Leptin signaling impairs macrophage defenses against Salmonella Typhimurium

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 33; pp. 16551 - 16560
• Main Authors: Fischer, Julia, Gutièrrez, Saray, Ganesan, Raja, Calabrese, Chiara, Ranjan, Rajeev, Cildir, Gökhan, Hos, Nina Judith, Rybniker, Jan, Wolke, Martina, Fries, Jochen W. U., Tergaonkar, Vinay, Plum, Georg, Antebi, Adam, Robinson, Nirmal
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 13.08.2019
• Series: PNAS Plus
• Subjects: Ablation; activation; Adult; AKT; AKT protein; Animals; Bacterial infections; Biological Sciences; cells; Crosstalk; expression; Farmaceutisk vetenskap; Female; Gram-negative bacteria; host-defense; Humans; Immune clearance; Immune response; Immune system; Immunity; infection; Infections; Inflammation - pathology; Innate immunity; leptin; Leptin - antagonists & inhibitors; Leptin - metabolism; lysosome; lysosomes; Lysosomes - metabolism; Macrophages; Macrophages - immunology; Macrophages - microbiology; Mechanistic Target of Rapamycin Complex 2 - metabolism; Metabolism; Mice; Mice, Inbred C57BL; Models, Biological; pathogen; Pathogens; Phagosomes - metabolism; Pharmaceutical Sciences; Phosphoprotein Phosphatases - metabolism; Phosphorylation; PNAS Plus; Proto-Oncogene Proteins c-akt - metabolism; RAW 264.7 Cells; receptor; Receptors, Leptin - metabolism; Regulators; Rodents; Salmonella; Salmonella Infections, Animal; Salmonella typhimurium - immunology; Signal Transduction; Signaling; Young Adult; Salmonella; macrophages; AKT; lysosomes; leptin

The dynamic interplay between metabolism and immune responses in health and disease, by which different immune cells impact on metabolic processes, are being increasingly appreciated. However, the potential of master regulators of metabolism to control innate immunity are less understood. Here, we s...